当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Gynura procumbens ethanol extract and its fractions inhibit macrophage derived foam cell formation.

Gynura procumbens ethanol extract and its fractions inhibit macrophage derived foam cell formation.

Abstract：

ETHNOPHARMACOLOGY RELEVANCE:Gynura procumbens (Lour.) Merr. displayed cardio-protective effect that may prevent atherogenesis. The primary underlying pathological process of cardiovascular disease is atherosclerosis. Atherosclerotic lesion composed of macrophages, T cells and other immune cells which incorporated with cholesterol that infiltrates from the blood. AIM OF THE STUDY:The present study was performed to determine underlying mechanism of G. procumbens ethanol extract and its fractions such as aqueous, chloroform, ethyl acetate and hexane affect macrophage derived foam cell formation. MATERIALS AND METHODS:Lipid droplets accumulation in treated macrophages were visualized by Oil Red O staining while the total cholesterol present in the treated macrophages were measured using Cholestryl Ester quantification assay kit. Enzyme-Linked Immunosorbent Assay (ELISA) were used to detect TNF-α and IL-1β secretion in the supernatant of treated macrophages. Gene expression of Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and ATP-binding cassette transporter A-1 (ABCA-1) in treated macrophages were analyzed using Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR). RESULTS:G. procumbens ethanol extract and its fractions reduced lipid droplet accumulation and total cholesterol in oxLDL-treated macrophages together with significantly reduction of TNF-α and IL-1β secretions in supernatant oxLDL-treated macrophages. LOX-1 gene expression was significantly reduced when G. procumbens ethanol extract and its fractions were added in oxDL-treated macrophages. In contrast, G. procumbens ethanol extract and its fractions significantly increased the expression of ABCA-1 gene in oxLDL-treated macrophages. CONCLUSION:In conclusion, G. procumbens ethanol extract and its fractions inhibit the formation of macrophage derived foam cell by reducing TNF-α and IL-1β expression, which usually highly expressed in atherosclerotic plaques, suppressing scavenger receptor LOX-1 gene that binds oxLDL but induced ABCA-1 gene that mediate lipid efflux from macrophages.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Manogaran M,Vuanghao L,Mohamed R

doi

10.1016/j.jep.2019.112410

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

112410

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(19)33115-0

journal_volume

249

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • In vitro purgative effect of Ruellia praetermissa. Sceinf.ex.Lindau (Acanthaceae).

    abstract：:Methanol, ethylacetate and aqueous extracts of Ruellia praetermissa initiated spontaneous contractions in the quiescent and increased contraction on the electrically stimulated ileal strip at a concentration of 30 microg/ml. The extracts produced concentration-related contractions both in amplitude and tone up till 75...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00204-x

    authors： Salah AM,Dongmo AB,Kamanyi A,Bopelet M,Vierling W,Wagner H

    更新日期：2000-09-01 00:00:00

  • Effect of traditional Chinese medicine formula GeGen decoction on primary dysmenorrhea: A randomized controlled trial study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:GeGen Decoction, a well-known Chinese herbal formula, is widely used in China and other Asian countries to treat gynecological diseases, including primary dysmenorrhea. Pharmacological studies have confirmed that GeGen Decoction is able to inhibit spasmodic contractions of the uterus in v...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113053

    authors： Chai C,Hong F,Yan Y,Yang L,Zong H,Wang C,Liu Z,Yu B

    更新日期：2020-10-28 00:00:00

  • Gan-Lu-Siao-Du-yin, a prescription of traditional Chinese medicine, inhibited enterovirus 71 replication, translation, and virus-induced cell apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gan-Lu-Siao-Du-yin (GLSDY) is a prescription of traditional Chinese medicine. GLSDY contains 11 ingredients and is commonly used for endemic diseases. Enterovirus 71 (EV71) is an endemic disease that can cause meningoencephalitis with mortality and neurologic sequelae without any effectiv...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.03.034

    authors： Hsieh YJ,Yen MH,Chiang YW,Yeh CF,Chiang LC,Shieh DE,Yeh I,Chang JS

    更新日期：2016-06-05 00:00:00

  • Studies on the antioxidant and hepatoprotective activities of polysaccharides from Talinum triangulare.

    abstract：UNLABELLED:ETHNOPHAMACOLOGICAL RELEVANCY: The whole plant of Talinum triangulare (Family: Portulacaceae) is used in variety of diseases including hepatic ailments in Africa and Taiwan of China. AIMS OF THE STUDY:The study was aimed to evaluate the antioxidant and hepatoprotective activity of polysaccharides from T. tr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.047

    authors： Liang D,Zhou Q,Gong W,Wang Y,Nie Z,He H,Li J,Wu J,Wu C,Zhang J

    更新日期：2011-06-22 00:00:00

  • Boldine action against the stannous chloride effect.

    abstract：:Peumus boldus extract has been used in popular medicine in the treatment of biliar litiase, hepatic insufficiency and liver congestion. Its effects are associated to the substance boldine that is present in its extract. In the present work, we evaluated the influence of boldine both in: (i) the structural conformation...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00120-8

    authors： Reiniger IW,Ribeiro da Silva C,Felzenszwalb I,de Mattos JC,de Oliveira JF,da Silva Dantas FJ,Bezerra RJ,Caldeira-de-Araújo A,Bernardo-Filho M

    更新日期：1999-12-15 00:00:00

  • Effect of Fructus Ligustri Lucidi on osteoblastic like cell-line MC3T3-E1.

    abstract：UNLABELLED:Fructus Ligustri Lucidi, fruits of Ligustrum lucidum Ait. (Oleaceae), has the effects of tonifying the liver and the kidney and strengthening the bones and muscles. In ancient times, Fructus Ligustri Lucidi can be prepared in ethanol or in water. Some active compounds have been found in Fructus Ligustri Luci...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.05.013

    authors： Li Q,Fan YS,Gao ZQ,Fan K,Liu ZJ

    更新日期：2015-07-21 00:00:00

  • Management of diabetic complications: a chemical constituents based approach.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2013.08.051

    authors： Singh R,Kaur N,Kishore L,Gupta GK

    更新日期：2013-10-28 00:00:00

  • Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk?

    abstract：:Aconitum species have been used in China as an essential drug in Traditional Chinese Medicine (TCM) for 2000 years. Reviewing the clinical application of Aconitum, their pharmacological effects, toxicity and detoxifying measures, herb-herb interactions, clinical taboos, famous herbal formulas, traditional and current ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2009.07.031

    authors： Singhuber J,Zhu M,Prinz S,Kopp B

    更新日期：2009-10-29 00:00:00

  • Some phytochemical aspects of medicinal plant research.

    abstract：:Various aspects of medicinal plant research, i.e. collection of data, screening for biological activity and isolation and identification of active compounds are briefly discussed with special reference to phytochemical aspects. Based upon this some topics for further methodological research are presented. A strategy f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(89)90044-5

    authors： Verpoorte R

    更新日期：1989-02-01 00:00:00

  • Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities. AIM OF THE STUDY:Allergic diseases are initiated by the development of allergen-specific T helper type 2 (Th2) cells and amplified by the degranulation of and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.12.041

    authors： Iwaki K,Ohashi E,Arai N,Kohno K,Ushio S,Taniguchi M,Fukuda S

    更新日期：2011-03-24 00:00:00

  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ulomoides dermestoides (Fairmaire, 1893) is a cosmopolitan tenebrionid beetle reared by Argentine people who consume them alive as an alternative medicine in the treatment of different illnesses such as asthma, Parkinson's, diabetes, arthritis, HIV and specially cancer. AIM OF THE STUDY:...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.056

    authors： Crespo R,Villaverde ML,Girotti JR,Güerci A,Juárez MP,de Bravo MG

    更新日期：2011-06-14 00:00:00

  • Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:For nearly 2000 years Sargassum spp., a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including thyroid disease (e.g. goitre). AIMS OF THE REVIEW:To assess the scientific evidence for therapeutic claims made for Sargassum spp. in TCM an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2012.05.046

    authors： Liu L,Heinrich M,Myers S,Dworjanyn SA

    更新日期：2012-08-01 00:00:00

  • Ovicidal and larvicidal activity of crude extracts of Maesa lanceolata and Plectranthus punctatus against Haemonchus contortus.

    abstract：:The widespread development of anthelmintic resistance and high cost of the conventional anthelmintic drugs, has limited the control of gastrointestinal nematode parasites of sheep and goats and hence led to evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in vitro ovicida...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.014

    authors： Tadesse D,Eguale T,Giday M,Mussa A

    更新日期：2009-03-18 00:00:00

  • The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.

    abstract：:'Teng-khia-u' is a folk medicine of Taiwan, derived from the entire plants of Elephantopus scaber L., E. mollis H.B.K. and Pseudoelephantopus spicatus (Juss.) Rohr. The hepatoprotective effects of water extracts of these three plants against beta-D-galactosamine (D-GalN)- and acetaminophen (APAP)-induced acute hepatic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01198-9

    authors： Lin CC,Tsai CC,Yen MH

    更新日期：1995-02-01 00:00:00

  • Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:[corrected] The Taxillus liquidambaricola has been used to treat rheumatic arthralgia, threatened abortion and hypertension in the Chinese traditional medicine. However, there is no scientific evidence which supports the use in the literature. This study aimed to determine the antioxidant...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.041

    authors： Deng JS,Chi CS,Huang SS,Shie PH,Lin TH,Huang GJ

    更新日期：2011-10-11 00:00:00

  • Antimicrobial activity of some important Adiantum species used traditionally in indigenous systems of medicine.

    abstract：:Adiantum Linn. of Adiantaceae family is one of the most common and widely distributed species. Ethnomedicinally, the genus is important and popularly known as "Hansraj" in Ayurvedic System of Medicine. It has been used in cold, tumors of spleen, liver and other viscera, skin diseases, bronchitis and inflammatory disea...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.018

    authors： Singh M,Singh N,Khare PB,Rawat AK

    更新日期：2008-01-17 00:00:00

  • The protective effect of the active components of ERPC on diabetic peripheral neuropathy in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY:The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix tricho...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.015

    authors： Hao GM,Liu YG,Wu Y,Xing W,Guo SZ,Wang Y,Wang ZL,Li C,Lv TT,Wang HL,Shi TJ,Wang W,Han J

    更新日期：2017-04-18 00:00:00

  • Anti-inflammatory activity of the bark of Hippocratea excelsa.

    abstract：:The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a prote...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01257-e

    authors： Perez RM,Perez S,Zavala MA,Salazar M

    更新日期：1995-07-07 00:00:00

  • Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats.

    abstract：:The antihypertensive and diuretic effects of the flavonoids extracted from Spergularia purpurea Pers. (SP) were studied both in normotensive (NTR) and spontaneously hypertensive conscious rats (SHR). Daily oral administration of the flavonoid mixture (5 mg/kg for 1 week) exhibited a significant decrease in blood press...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00209-4

    authors： Jouad H,Lacaille-Dubois MA,Lyoussi B,Eddouks M

    更新日期：2001-07-01 00:00:00

  • Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: a review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The present study has indicated phytochemical composition, distribution and ethno-medicinal uses of Arnebia euchroma (Royle) I.M. Johnst, which is commonly known as "Ratanjot" in the Indian subcontinent. It has widely been used in the traditional systems of the Unani, Ayurvedic and Chines...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113896

    authors： Kumar A,Shashni S,Kumar P,Pant D,Singh A,Verma RK

    更新日期：2021-01-29 00:00:00

  • The use of South African botanical species for the control of blood sugar.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Diabetes mellitus (DM) is one of the most prevalent diseases globally and is of considerable concern to global health. Approximately 425 million people are estimated to have DM globally and this is predicted to increase to >642 million by 2040. Whilst the prevalence of DM in South Africa ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113234

    authors： Cock IE,Ndlovu N,Van Vuuren SF

    更新日期：2021-01-10 00:00:00

  • Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots.

    abstract：:Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One iso...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.10.012

    authors： Choi JH,Rho MC,Lee SW,Kwon OE,Park HR,Kang JY,Lee SH,Lee HS,Bae KH,Kim YK

    更新日期：2007-04-04 00:00:00

  • Integration of organ metabolomics and proteomics in exploring the blood enriching mechanism of Danggui Buxue Decoction in hemorrhagic anemia rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Danggui Buxue Decoction (DBD), as a classical Chinese medicine prescription, is composed of Danggui (DG) and Huangqi (HQ) at a ratio of 1:5, and it has been used clinically in treating anemia for hundreds of years. AIM OF THE STUDY:The aim of this study was to explore the treatment mecha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113000

    authors： Shi XQ,Zhu ZH,Yue SJ,Tang YP,Chen YY,Pu ZJ,Tao HJ,Zhou GS,Yang Y,Guo MJ,Ting-Xia Dong T,Tsim KW,Duan JA

    更新日期：2020-10-28 00:00:00

  • β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The plant Arenaria kansuensis is used in traditional medicine to treat lung inflammation for a long time. However, the anti-pulmonary fibrosis effect and its corresponding bioactive constituents of this plant have not been studied extensively. AIM OF THE STUDY:The purpose of this study w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112096

    authors： Cui Y,Jiang L,Yu R,Shao Y,Mei L,Tao Y

    更新日期：2019-10-28 00:00:00

  • The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus.

    abstract：:This study was undertaken to investigate whether a tea prepared from Syzygium cumini, reported to be used by diabetics in Porto Alegre, Brazil, might have an antihyperglycemic effect in experimental models. Teas prepared from leaves and seeds of S. cumini, in concentrations ranging from 2-64 g/l, were administered, as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)01532-8

    authors： Teixeira CC,Pinto LP,Kessler FH,Knijnik L,Pinto CP,Gastaldo GJ,Fuchs FD

    更新日期：1997-05-01 00:00:00

  • Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Enhancement of cholinergic functions in the brain via acetylcholinesterase inhibition is one of the main therapeutic strategies to improve symptoms associated with Alzheimer's or related cognitive deficits. There is a pathophysiological correlation between Alzheimer's and Diabetes Mellitu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112160

    authors： Amir Rawa MS,Hassan Z,Murugaiyah V,Nogawa T,Wahab HA

    更新日期：2019-12-05 00:00:00

  • Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as "Ashwagandha". A number of published reports suggest various uses for WA including its function as an anti-inflammatory and anti-angiogenic drug molecule. The effects ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.09.024

    authors： Narayan M,Seeley KW,Jinwal UK

    更新日期：2015-12-04 00:00:00

  • Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants from genus Lavandula have been used as anti-inflammatory drugs in Mediterranean traditional medicine. Nowadays, there is a growing interest for complementary medicine, including herbal remedies, to treat inflammatory bowel disease (IBD). AIM OF THE STUDY:To test the anti-inflammat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.05.063

    authors： Algieri F,Rodriguez-Nogales A,Vezza T,Garrido-Mesa J,Garrido-Mesa N,Utrilla MP,González-Tejero MR,Casares-Porcel M,Molero-Mesa J,Del Mar Contreras M,Segura-Carretero A,Pérez-Palacio J,Diaz C,Vergara N,Vicente F,Rodriguez-Ca

    更新日期：2016-08-22 00:00:00

  • Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The antiulcer potentials of most plants still remain largely unexplored, despite their prospects evidenced by their use as ethnomedicine. Entada africana (Mimosaceae) has been widely used in Africa for the treatment of skin infections, wounds, tonic for stomach troubles and against diphth...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.06.012

    authors： Obidike IC,Emeje MO

    更新日期：2011-09-01 00:00:00

  • Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Diabetic foot ulceration results in high risk of lower extremity amputation, and represents a significant health care expenditure worldwide. Radix Astragali (RA) and Radix Rehmanniae (RR) are widely used Chinese medicinal herbs in treating diabetes, and have shown positive effects in enha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.11.031

    authors： Tse HY,Hui MN,Li L,Lee SM,Leung AY,Cheng SH

    更新日期：2012-01-31 00:00:00