当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats.

Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats.

Abstract：

:The antihypertensive and diuretic effects of the flavonoids extracted from Spergularia purpurea Pers. (SP) were studied both in normotensive (NTR) and spontaneously hypertensive conscious rats (SHR). Daily oral administration of the flavonoid mixture (5 mg/kg for 1 week) exhibited a significant decrease in blood pressure with variation coefficient (Delta) of 20 in SHR rats and 11 in NTR rats. The systolic and diastolic blood pressure decreased significantly and respectively with 17 and 24% in SHR, and with 11 and 16% in NTR. The flavonoid mixture enhanced significantly the water excretion in hypertensive (P<0.001) and normal rats (P<0.001). Furthermore, oral administration of flavonoids mixture at a dose of 5 mg/kg produced a significant increase of urinary excretion of sodium (P<0.01), potassium (P<0.05) and chlorides (P<0.05) in SHR. Similarly, the flavonoid administration induced a significant increase of urinary electrolytes elimination in NTR (P<0.01 versus controls). No significant changes were noted on heart rate after flavonoids treatment in SHR as well as in NTR. While, glomerular filtration rate showed a significant increase after administration of flavonoids in all groups (P<0.05). These results suggest that oral administration of flavonoids obtained from Spergularia purpurea exhibited antihypertensive and diuretic actions.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Jouad H,Lacaille-Dubois MA,Lyoussi B,Eddouks M

doi

10.1016/s0378-8741(01)00209-4

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

159-63

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(01)00209-4

journal_volume

76

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Traditional plants used for medicinal purposes by local communities around the Northern sector of Kibale National Park, Uganda.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The study was done to establish medicinal plants used in the treatment of various diseases by the people in the Northern sector of Kibale National Park in western Uganda. It was also aimed at establishing the plant parts used and the mode of preparation of remedies. These plants create a ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.044

    authors： Namukobe J,Kasenene JM,Kiremire BT,Byamukama R,Kamatenesi-Mugisha M,Krief S,Dumontet V,Kabasa JD

    更新日期：2011-06-14 00:00:00

  • Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.

    abstract：:Galangin is one of the active antimicrobial principles of propolis or 'bee glue' and Helichrysum aureonitens, a perennial herb used by South African indigenes to treat infection. The effect of this compound and antibacterial agents with known mechanisms of action upon the cytoplasmic membrane integrity of Staphylococc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.04.014

    authors： Cushnie TP,Lamb AJ

    更新日期：2005-10-03 00:00:00

  • Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease.

    abstract：AIM OF THE STUDY:Previous studies in our laboratory revealed the neuroprotective effect of modified Yeoldahanso-tang (MYH) in models of Parkinson׳s disease (PD). In this study, we investigated another traditional Korean herbal formula, modified Chungsimyeolda-tang (termed DG), as a potential treatment for PD. Chungsimy...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.11.007

    authors： Bae N,Chung S,Kim HJ,Cha JW,Oh H,Gu MY,Oh MS,Yang HO

    更新日期：2015-01-15 00:00:00

  • Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants from the Caatinga, a Brazilian xeric shrubland, are used in folk medicine to treat infections. These ethnopharmacological data can contribute to obtaining new antimicrobial/antibiofilm extracts and natural product prototypes for the development of new drugs. The aim of th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.030

    authors： Trentin Dda S,Giordani RB,Zimmer KR,da Silva AG,da Silva MV,Correia MT,Baumvol IJ,Macedo AJ

    更新日期：2011-09-01 00:00:00

  • Evaluation of spasmolytic activity of clausmarin-A. a novel coumarin from Clausena pentaphylla (Roxb.) DC.

    abstract：:Crude ethanolic (50%) extracts of five species of Clausena exhibited varying degrees of spasmolytic activity on the isolated guinea-pig ileum preparation. The aerial parts of Clausena pentaphylla had maximum activity. Its active principle clausmarin-A, a novel coumarin terpenoid, was evaluated in detail for spasmolyti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(82)90001-0

    authors： Patnaik GK,Dhawan BN

    更新日期：1982-09-01 00:00:00

  • Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Indigofera argentea Burm. f.; commonly known as neel, jantari, hathio; is traditionally used for the treatment of headache, fever, inflammation and body pain. Local communities also used this plant for the treatment of malaria, jaundice, vertigo and gastric disorders. AIM OF THE STUDY:Th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112966

    authors： Javed F,Jabeen Q,Aslam N,Awan AM

    更新日期：2020-09-15 00:00:00

  • New role for crinamine as a potent, safe and selective inhibitor of human monoamine oxidase B: In vitro and in silico pharmacology and modeling.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The development of selective inhibitors of monoamine oxidase B (MAO-B) has been essential in treating Parkinson's disease. However, the apparent hepatotoxicity and drug-drug interactions of current inhibitors accentuate the need for the development of novel pharmacotherapies. Crossyne gut...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112305

    authors： Naidoo D,Roy A,Slavětínská LP,Chukwujekwu JC,Gupta S,Van Staden J

    更新日期：2020-02-10 00:00:00

  • Metabolites and the pharmacokinetics of kobophenol A from Caragana sinica in rats.

    abstract：:This research aims to study the metabolism and pharmacokinetics of phytoestrogen kobophenol A (1), the main active compound of Caragana sinica (Buc'hoz) Rehd. (Fabaceae), in rats. Metabolites of 1 in rats' feces were isolated and purified by multi-chromatograph techniques; three new metabolites of 1, named koboquinone...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.05.016

    authors： Liang GL,Bi JB,Huang HQ,Zhang S,Hu CQ

    更新日期：2005-10-03 00:00:00

  • Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Scutellariae Radix (SR), the dried root of Scutellariae baicalensis Georgi, has a lot in common with non-steroidal anti-inflammatory drugs (NSAIDs). Their similarities in therapeutic action (anti-inflammation) and metabolic pathways (phase II metabolisms) may lead to co-administration by ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.036

    authors： Fong SY,Wong YC,Xie C,Zuo Z

    更新日期：2015-07-21 00:00:00

  • Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (ginseng, Panax ginseng C.A. Meyer) is a famous traditional drug used in Korea for the treatment and prevention of obesity, type 2 diabetes, cancer, and liver and cardiovascular diseases. Menopause is strongly associated with many of the aforementioned metabolic disease...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.12.017

    authors： Lee H,Choi J,Shin SS,Yoon M

    更新日期：2016-02-03 00:00:00

  • Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography.

    abstract：:The estrogenic activity of traditional Chinese herb-Polygonum cuspidatum Sieb. et Zucc. was investigated by a recombinant yeast screening (YES) assay. Anthraquinones are the main components in the plant, of which emodin is the most abundant one. The ethyl acetate fraction of the ethanol extract of Polygonum cuspidatum...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.10.029

    authors： Zhang C,Zhang X,Zhang Y,Xu Q,Xiao H,Liang X

    更新日期：2006-04-21 00:00:00

  • Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute de...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113773

    authors： Xiong X,Huang C,Wang F,Dong J,Zhang D,Jiang J,Feng Y,Wu B,Xie T,Cheng L

    更新日期：2020-12-31 00:00:00

  • In search of the perfect aphrodisiac: parallel use of bitter tonics in West Africa and the Caribbean.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Enslaved Africans in the Americas had to reinvent their medicinal flora in an unknown environment by adhering to plants that came with them, learning from Amerindians and Europeans, using their Old World knowledge and trial and error to find substitutes for their homeland herbs. This proc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.08.008

    authors： van Andel T,Mitchell S,Volpato G,Vandebroek I,Swier J,Ruysschaert S,Rentería Jiménez CA,Raes N

    更新日期：2012-10-11 00:00:00

  • Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Schinus lentiscifolius Marchand (syn. Schinus weinmannifolius Engl) is a plant native to Rio Grande do Sul (Southern Brazil) and has been used in Brazilian traditional medicine as antiseptic and antimicrobial for the treatment of many different health problems as well as to treat leucorrh...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.04.043

    authors： Gehrke IT,Neto AT,Pedroso M,Mostardeiro CP,Da Cruz IB,Silva UF,Ilha V,Dalcol II,Morel AF

    更新日期：2013-07-09 00:00:00

  • Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

    abstract：AIM OF THE STUDY:Tanshinone IIA (T), salvianolic acid B (S) and ginsenoside Rb1 (G) are the three major active ingredients of Compound Danshen Formula (CDF) for its protective effects on myocardial ischemia (MI). In this study, we aimed to investigate therapeutic and synergistic effects of TSG (combination of T, S and ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.048

    authors： Lu Y,Liu X,Liang X,Xiang L,Zhang W

    更新日期：2011-03-08 00:00:00

  • Anticancer medicinal plants used by Moroccan people: Ethnobotanical, preclinical, phytochemical and clinical evidence.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cancer is a major health problem worldwide. Drugs' side effects and high cost of treatment remain the main limitations of conventional therapy. Nowadays, developing new therapeutic strategies is necessary. Therefore, medicinal plants can be used to promote novel, safe, and potent anticanc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113435

    authors： Alami Merrouni I,Elachouri M

    更新日期：2021-02-10 00:00:00

  • Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Artemisia princeps Pampanini is widely used in Eastern traditional medicine for the treatment of circulatory disorders, such as, dysmenorrhea, hematuria, hemorrhoids, and inflammation, and is also used to treat chronic conditions, such as, cancers, ulcers, and digestive disorders. AIM OF...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.011

    authors： Ju HK,Lee HW,Chung KS,Choi JH,Cho JG,Baek NI,Chung HG,Lee KT

    更新日期：2012-05-07 00:00:00

  • Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.

    abstract：:Since ages Mallotus peltatus (Geist) Muell. Arg. var acuminatus (Euphorbiaceae) leaf and stem bark is used in folk medicine to cure intestinal ailments and skin infections. In several intestinal ailments, localized inflammation is of common occurrence and hence we have evaluated the antimicrobial as well as anti-infla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00165-4

    authors： Chattopadhyay D,Arunachalam G,Mandal AB,Sur TK,Mandal SC,Bhattacharya SK

    更新日期：2002-10-01 00:00:00

  • Investigations on Dieffenbachia amoena Gentil. I: Endocrine effects and contraceptive activity.

    abstract：:Contraceptive activity and the correlated endocrine alterations of an aqueous extract of the leaves of Dieffenbachia amoena were investigated. In female Wistar rats the extract, given for 4 days during the estrous cycle, induced significant variations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), pr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(84)90059-x

    authors： Costa de Pasquale R,Ragusa S,Circosta C,Forestieri AM

    更新日期：1984-12-01 00:00:00

  • Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.

    abstract：:Phyllanthus maderaspatensis (whole plant extracts) was evaluated for its antihepatotoxic and choleretic activities in rats. The plant extracts (200 mg/kg, n-hexane, ethyl alcohol or water) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum marker enzymes...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.02.005

    authors： Asha VV,Akhila S,Wills PJ,Subramoniam A

    更新日期：2004-05-01 00:00:00

  • Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. AIM OF THE STUDY:We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. MATERIALS AND METHODS:The e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.11.006

    authors： Cho E,Cho SH

    更新日期：2013-01-09 00:00:00

  • Antibacterial activities of extracts from Ugandan medicinal plants used for oral care.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants are widely used for treatment of oral/dental diseases in Uganda. AIM OF THE STUDY:To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC). MATERIALS AND METHODS:Pulp ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.06.027

    authors： Ocheng F,Bwanga F,Joloba M,Borg-Karlson AK,Gustafsson A,Obua C

    更新日期：2014-08-08 00:00:00

  • Anti-inflammatory activity of oleoresin from Brazilian Copaifera.

    abstract：:The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effect...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(88)90235-8

    authors： Basile AC,Sertié JA,Freitas PC,Zanini AC

    更新日期：1988-01-01 00:00:00

  • Further pharmacological studies on aqueous seed extract of Aframomum melegueta in rats.

    abstract：:This present study investigates the effect of an aqueous seed extract of Aframomum melegueta, on leukocytes migration and on phenylhydrazine-treated rat red blood cells (RBC). The effect of Aframomum melegueta on the number of white blood cells (WBC), in inflammatory exudates, was assessed by utilizing the granuloma a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.10.019

    authors： Umukoro S,Ashorobi BR

    更新日期：2008-02-12 00:00:00

  • Lippia: traditional uses, chemistry and pharmacology: a review.

    abstract：:The chemical composition, pharmacological activity and traditional uses of 52 species attributed to the genus Lippia (Verbenaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for the treatment of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-8741(01)00234-3

    authors： Pascual ME,Slowing K,Carretero E,Sánchez Mata D,Villar A

    更新日期：2001-08-01 00:00:00

  • Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Solanum torvum (Solanaceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. AIM OF THE STUDY:The present study was undertaken to determine the anti-ulcer potential of the aqueous and methanol extracts from the leaves of Solanum torvum. MATERIAL...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.06.008

    authors： Nguelefack TB,Feumebo CB,Ateufack G,Watcho P,Tatsimo S,Atsamo AD,Tane P,Kamanyi A

    更新日期：2008-09-02 00:00:00

  • Shuangshen granules attenuate lung metastasis by modulating bone marrow differentiation through mTOR signalling inhibition.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional Chinese medicine Shuangshen granules (SSG) have been used to treat lung cancer patients with Qi deficiency and blood stasis for decades. According to clinical experience, SSG indeed improve the quality of life and prolong the survival time of patients with lung cancer after su...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113305

    authors： Wei H,Guo C,Zhu R,Zhang C,Han N,Liu R,Hua B,Li Y,Lin H,Yu J

    更新日期：2020-09-02 00:00:00

  • In-vitro (2D and 3D cultures) and in-vivo cytotoxic properties of Zataria multiflora essential oil (ZEO) emulsion in breast and cervical cancer cells along with the investigation of immunomodulatory potential.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zataria multiflora is an iranian valuable traditional plants, called Avishan Shirazi in Persian language used to reduce inflammation, spasm, pain, and cancer symptoms. Zataria essential oil (ZEO) is one of the essential oils possessing broad biological activities. AIM OF THE STUDY:The ai...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112865

    authors： Azadi M,Jamali T,Kianmehr Z,Kavoosi G,Ardestani SK

    更新日期：2020-07-15 00:00:00

  • Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice.

    abstract：AIM OF THE STUDY:Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.035

    authors： Bras C,Domínguez S,Codón S,Minetti A,Ferrero A

    更新日期：2010-10-28 00:00:00

  • Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cimicifuga foetida L., a traditional Chinese medicine, has been used as an anti-inflammatory, antipyretic and analgesic remedy. The primary active constituents are believed to be present in the triterpene glycoside fraction. MATERIALS AND METHODS:To develop an LC-MS/MS assay for four maj...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.06.031

    authors： Gai YY,Liu WH,Sha CJ,Wang YL,Sun YT,Li XJ,Paul Fawcett J,Gu JK

    更新日期：2012-08-30 00:00:00