Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.

Abstract:

:Phyllanthus maderaspatensis (whole plant extracts) was evaluated for its antihepatotoxic and choleretic activities in rats. The plant extracts (200 mg/kg, n-hexane, ethyl alcohol or water) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum marker enzymes. The water and ethyl alcohol extracts showed moderate activity compared to the n-hexane extract, which showed activity at a dose as low as 1.5 mg/kg. The antihepatotoxicity of the hexane extract was found to be better than silymarin, a standard hepatoprotective herbal drug. The effect of n-hexane extract was found to be concentration-dependent. This extract also exhibited choleretic activity in normal rats, and in vitro hydroxyl radical scavenging activity and inhibition of lipid peroxidation.

journal_name

J Ethnopharmacol

authors

Asha VV,Akhila S,Wills PJ,Subramoniam A

doi

10.1016/j.jep.2004.02.005

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

67-70

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874104000674

journal_volume

92

pub_type

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