Antimalarial activity from 'Mhekara' (Uapaca nitida Müll-Arg.), a Tanzanian tree.

Abstract:

:An aqueous decoction of the root bark of Uapaca nitida Müll-Arg. is currently used locally at the Benedictine Mission at Peramiho in Tanzania to treat malaria. We have now demonstrated that extracts of root bark and leaves of this tree are active against the multidrug-resistant K1 strain of Plasmodium falciparum in vitro. An ethanolic extract of root bark showed activity against P. berghei in mice but at a dose which also showed toxic effects. The use of this plant in treating malaria appears to be novel and further studies would be of value.

journal_name

J Ethnopharmacol

authors

Kirby GC,Khumalo-Ngwenya NB,Grawehr A,Fison TW,Warhurst DC,Phillipson JD

doi

10.1016/0378-8741(93)90088-m

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

47-51

issue

1

eissn

0378-8741

issn

1872-7573

pii

0378-8741(93)90088-M

journal_volume

40

pub_type

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