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In vitro purgative effect of Ruellia praetermissa. Sceinf.ex.Lindau (Acanthaceae).

Abstract：

:Methanol, ethylacetate and aqueous extracts of Ruellia praetermissa initiated spontaneous contractions in the quiescent and increased contraction on the electrically stimulated ileal strip at a concentration of 30 microg/ml. The extracts produced concentration-related contractions both in amplitude and tone up till 750 microg/ml with IC(50) of 360 microg/ml (methanol extract), 425 microg/ml (ethylacetate extract) and 540 microg/ml (aqueous extract). Acetylcholine also produced a concentration-related (IC(50)=18 microg/ml) contractions of the isolated ileum. Atropine in concentrations of 3.4 x 10(-6)-3 x 10(-3) microg/ml antagonized progressively the response of the isolated ileum to acetylcholine (32 x 10(-2) microg/ml) and the methanol extract (650 microg/ml) induced contractions suggesting a mode of action via cholinergic system. Luteolin and apigenin and iridoid glucosides (taxiphilin and 8-epi-deoyganic acid) might be responsible at least in part for the observed effect.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Salah AM,Dongmo AB,Kamanyi A,Bopelet M,Vierling W,Wagner H

doi

10.1016/s0378-8741(00)00204-x

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

269-72

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(00)00204-X

journal_volume

72

pub_type

杂志文章

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