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Insamhodo-tang, a traditional Korean medicine, regulates mast cell-mediated allergic inflammation in vivo and in vitro.

Abstract：

AIM OF THE STUDY:Insamhodo-tang (IHT) has traditionally been used in Korea to treat a variety of diseases, including chronic cough, tuberculosis, and chronic bronchitis. However, the anti-allergic and anti-inflammatory effects of IHT and its molecular mechanisms have yet to be clearly elucidated. In this study, we attempted to evaluate the effects of IHT on mast cell-mediated allergy inflammation in vitro and in vivo. MATERIALS AND METHODS:We investigated to ascertain the pharmacological effects of IHT on both compound 48/80-induced and 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find a possible explanation for the anti-inflammatory mechanisms of IHT, we evaluated the regulatory effects of IHT on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). RESULTS:The finding of this study demonstrated that IHT reduced compound 48/80-induced systemic anaphylactic shock, DNFB-induced dermatitis, and ear swelling responses in mice. Additionally, IHT inhibited the production of interleukin (IL)-6, IL-8, and TNF-α, as well as the activation of nuclear factor-κB and caspase-1 in PMACI-stimulated HMC-1. CONCLUSION:Collectively, the findings of this study provide us with a novel insight into the pharmacological actions of IHT as a potential molecule for use in the treatment of allergic inflammation diseases.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kim SJ,Kee JY,Choi IY,Kim MC,Kim DS,Jeon YD,Kim SG,Kim BS,Jung HJ,Kim HM,Hong SH,Um JY

doi

10.1016/j.jep.2010.12.023

subject

Has Abstract

pub_date

2011-03-24 00:00:00

pages

339-47

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00899-8

journal_volume

134

pub_type

杂志文章

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