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Protective effect of GCSB-5, an herbal preparation, against peripheral nerve injury in rats.

Abstract：

AIM OF THE STUDY:GCSB-5 (traditional name: Chungpa-Juhn), an herbal medicine composed of 6 crude herbs (Saposhnikovia divaricata Schiskin, Achyranthis bidentata Blume, Acanthopanax sessiliflorum Seem, Cibotium baromets J. Smith, Glycine max Meriill, and Eucommia ulmoides Oliver), has been widely used in Asia for treatment of neuropathic and inflammatory diseases. This study investigated the protective effect of GCSB-5 against peripheral nerve injury in vitro and in vivo. MATERIALS AND METHODS:After left sciatic nerve transection, rats received oral administration of GCSB-5 (30, 100, 300, and 600 mg/kg), or saline (vehicle), respectively, once daily for 8 weeks. Motor functional recovery and axonal nerve regeneration were evaluated by measurement of sciatic functional index (SFI), sensory regeneration distance, and gastrocnemius muscle mass ratio. The myelinated axon number was counted by morphometric analysis. In the in vitro study, the effects of GCSB-5 on H(2)O(2)-induced oxidative damage in SH-SY5Y cells were investigated by measurement of cell viability, production of reactive oxygen species (ROS), lipid peroxidation, release of lactate dehydrogenease (LDH), and cellular glutathione contents. Neurite outgrowth was also determined. RESULTS:After 8 weeks of nerve transection, SFI, regeneration distance, and gastrocnemius muscle mass ratio and myelinated axon number showed a significant decrease and these decreases were attenuated by GCSB-5. GCSB-5 significantly inhibited H(2)O(2)-induced cell death and oxidative stress, as evidenced by decreases in production of ROS and lipid peroxidation and release of LDH, and by increase in total GSH content. CONCLUSIONS:The neuroprotective effect afforded by GCSB-5 is due in part to reduced oxidative stress.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kim TH,Yoon SJ,Lee WC,Kim JK,Shin J,Lee S,Lee SM

doi

10.1016/j.jep.2011.04.037

subject

Has Abstract

pub_date

2011-06-22 00:00:00

pages

297-304

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00277-7

journal_volume

136

pub_type

杂志文章

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