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Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats.

Abstract：

:Mikania laevigata (Asteraceae) is a native plant from South America and popularly used as antispasmodic and to treat respiratory diseases. Coumarin is the major chemical substance found in this plant, which have been shown to have antifertility activity in female rats. This study evaluates the toxicity of the exposure to the Mikania laevigata syrup using coumarin as chemical marker on reproductive endpoints in male Wistar rats. Endpoints including reproductive organs weight, sperm and spermatids numbers and sperm morphology were evaluated. Animals were treated daily with Mikania laevigata syrup (3.5; 7.0 and 14.0mg/kg of coumarin) during 90 days by oral gavage. No alterations were observed in body and organ weights, sperm and spermatids numbers as well as sperm morphology of the male rats after the exposure to the Mikania laevigata syrup. Results therefore suggest absence of male reproductive toxicity of the Mikania laevigata syrup at tested doses.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Graça C,Freitas CS,Baggio CH,Dalsenter PR,Marques MC

doi

10.1016/j.jep.2006.10.039

subject

Has Abstract

pub_date

2007-04-20 00:00:00

pages

29-32

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00589-7

journal_volume

111

pub_type

杂志文章

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