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The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.

Abstract：

:Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, is currently one of the most important traditional Chinese herbal medicines. We investigated the anti-proliferation effect of oridonin on the cultured murine melanoma cell line K1735M2. The growth inhibition activity of oridonin for K1735M2 cells occurred in a time- and dose-dependent manner (IC50 was 7.4+/-0.6 microM). Further studies showed that these inhibition effects were associated with dose-dependent G2/M phase arrest and differentiation induction. Detection of morphological observation showed that oridonin could induce K1735M2 cells to produce dendrite-like structures. The results of the migration indicated that oridonin affected motility of K1735M2 cells in a dose-dependent manner. These results suggested that oridonin is a potential candidate for melanoma cancer therapy.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Ren KK,Wang HZ,Xie LP,Chen DW,Liu X,Sun J,Nie YC,Zhang RQ

doi

10.1016/j.jep.2005.07.020

keywords:

subject

Has Abstract

pub_date

2006-01-16 00:00:00

pages

176-80

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00519-2

journal_volume

103

pub_type

杂志文章

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