Abstract：
AIMS OF THE STUDY:Tripterygium wilfordii Hoog f., a perennial vine, is used in traditional Chinese medicine for treatment of rheumatoid arthritis. This study was to determine whether tripterine, isolated from Tripterygium wilfordii Hoog f., had therapeutic effects on adjuvant arthritis. MATERIALS AND METHODS:Adjuvant arthritis (AA) was induced in rats on day 0. Tripterine 5, 10 and 20 mg kg(-1)day(-1), or prednisone 10 mg kg(-1)day(-1) was given to rats intragastrically from day 19 to day 24. RESULTS:Tripterine significantly inhibited paw swelling and bone destruction in AA rats. Serum level of IgG anti-Mycobacterium tuberculosis antibodies and delayed-type hypersensitivity (DTH) induced by Mycobacterium tuberculosis were also decreased by tripterine. The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats. CONCLUSIONS:These findings suggested that tripterine had a therapeutic effect on adjuvant arthritis.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Li H,Zhang YY,Tan HW,Jia YF,Li Ddoi
10.1016/j.jep.2008.05.028subject
Has Abstractpub_date
2008-08-13 00:00:00pages
479-84issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(08)00276-6journal_volume
118pub_type
杂志文章abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The research into bioactive natural products originating from medicinal plants, fungi and other organisms has a long history, accumulating abundant and diverse publications. However no quantitative literature analysis has been conducted so far. AIM OF THE STUDY:Here we analyze the biblio...
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants are widely used for treatment of oral/dental diseases in Uganda. AIM OF THE STUDY:To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC). MATERIALS AND METHODS:Pulp ...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2005-02-28 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：1987-05-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb.(PM), (known as Heshouwu () in China) is one of the most important and well mentioned Chinese medicinal herbs in the literature for its use in blackening hair, nourishing liver and kidney, anti-aging, anti-hyperlipidemia, antioxidant, anti-inflammatory, antican...
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