The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury.

Abstract:

:This study was undertaken to investigate the protective effects of Phyllanthus emblica Linn. (PE) extract on ethanol induced rat hepatic injury. PE (0.5 and 1 mg/ml) increased cell viability of rat primary cultured hepatocytes being treated with ethanol (96 microl/m) by increasing % MTT and decreasing the release of transaminase. Hepatotoxic markers studied in rats included serum transaminases (AST and ALT), serum triglyceride (STG), hepatic triglyceride (HTG), TNF-alpha and IL-1beta together with histopathological examination. Pretreatment of rats with PE at oral dose of 25, 50 and 75 mg/kg or SL (silymarin, a reference hepatoprotective agent) at 5 mg/kg, 4 h before ethanol, lowered the ethanol induced levels of AST, ALT and IL-1beta. The 75 mg/kg PE dose gave the best result similar to SL. Treatment of rats with PE (75 mg/kg/day) or SL (5 mg/kg/day) for 7 days after 21 days with ethanol (4 g/kg/day, p.o.) enhanced liver cell recovery by bringing the levels of AST, ALT, IL-1beta back to normal. Histopathological studies confirmed the beneficial roles of PE and SL against ethanol induced liver injury in rats.

journal_name

J Ethnopharmacol

authors

Pramyothin P,Samosorn P,Poungshompoo S,Chaichantipyuth C

doi

10.1016/j.jep.2006.03.035

subject

Has Abstract

pub_date

2006-10-11 00:00:00

pages

361-4

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00170-X

journal_volume

107

pub_type

杂志文章
  • Huperzia saururus, activity on synaptic transmission in the hippocampus.

    abstract::Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory. The cholinergic neurons of the basal forebrain, including those in the medial septum, and in the vertical limbs of the diagonal band of Broca and the nucleus basalis of Meynert, provide a major sou...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.11.002

    authors: Ortega MG,Vallejo MG,Cabrera JL,Pérez MF,Almirón RS,Ramírez OA,Agnese AM

    更新日期:2006-04-06 00:00:00

  • Antifungal activity of some coumarins obtained from species of Pterocaulon (Asteraceae).

    abstract::Fractionation of antifungal hexane extracts of the aerial parts of three Pterocaulon spp., Pterocaulon alopecuroides, Pterocaulon balansae and Pterocaulon polystachyum (Asteraceae) from South Brazil traditionally used to treat animal mycoses, afforded the coumarins 5-methoxy-6,7-methylenedioxycoumarin, 7-(2',3'-epoxy-...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.02.009

    authors: Stein AC,Alvarez S,Avancini C,Zacchino S,von Poser G

    更新日期:2006-08-11 00:00:00

  • Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing.

    abstract:AIM OF THE STUDY:Genus Aloe has been traditionally utilized for medicinal purpose for decades. Compared with Aloe vera gel, the qualitative assessment for the therapeutic effects of the other two Aloe species, Aloe ferox Miller and Aloe arborescens Miller, for their topical wound healing was less addressed. Therefore, ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2008.08.008

    authors: Jia Y,Zhao G,Jia J

    更新日期:2008-11-20 00:00:00

  • Antifungal, anti-inflammatory and antioxidant activity of bi-herbal mixtures with medicinal plants from Argentinean highlands.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Argentinean medicinal plants such as Larrea divaricata Cav., Larrea cuneifolia Cav., Larrea nitida Cav., Zuccagnia punctata Cav. and Tetraglochin andina Ciald. are used alone and in combination in traditional medicine by inhabitants from northwestern Argentina to solve mycosis, vaginal in...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.112642

    authors: Moreno MA,Zampini IC,Isla MI

    更新日期:2020-05-10 00:00:00

  • β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The plant Arenaria kansuensis is used in traditional medicine to treat lung inflammation for a long time. However, the anti-pulmonary fibrosis effect and its corresponding bioactive constituents of this plant have not been studied extensively. AIM OF THE STUDY:The purpose of this study w...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112096

    authors: Cui Y,Jiang L,Yu R,Shao Y,Mei L,Tao Y

    更新日期:2019-10-28 00:00:00

  • Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract:ETHNOPHARMOCOLOGICAL RELEVANCE:Cortex Eucommiae (CE), the bark of Eucommia ulmoides Oliv., has been traditionally used for its kidney-tonifying and bone- and tendon-enhancing properties in Korea, China, and Japan. CE has been historically prescribed for inflammatory conditions such as arthritis of the knee and ankle. ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.08.001

    authors: Koh W,Shin JS,Lee J,Lee IH,Lee SK,Ha IH,Chung HJ

    更新日期:2017-09-14 00:00:00

  • In vitro antigonococcal activity of Coscinium fenestratum stem extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Gonorrhea is a sexually transmitted disease (STD), which originates from bacteria, Neisseria gonorrhoeae. It is still one of the major health problems worldwide in both men and women. Many medicinal plants have been recorded in Thai folk medicine for relieving STD but there is no scientif...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2009.01.036

    authors: Chomnawang MT,Trinapakul C,Gritsanapan W

    更新日期:2009-04-21 00:00:00

  • Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

    abstract:AIM:Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.02.005

    authors: Cao H,Chen X,Sun H,Sakurai T,Zhou J,Sun W,Lv H,Wang X

    更新日期:2010-04-21 00:00:00

  • Integration of organ metabolomics and proteomics in exploring the blood enriching mechanism of Danggui Buxue Decoction in hemorrhagic anemia rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Danggui Buxue Decoction (DBD), as a classical Chinese medicine prescription, is composed of Danggui (DG) and Huangqi (HQ) at a ratio of 1:5, and it has been used clinically in treating anemia for hundreds of years. AIM OF THE STUDY:The aim of this study was to explore the treatment mecha...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113000

    authors: Shi XQ,Zhu ZH,Yue SJ,Tang YP,Chen YY,Pu ZJ,Tao HJ,Zhou GS,Yang Y,Guo MJ,Ting-Xia Dong T,Tsim KW,Duan JA

    更新日期:2020-10-28 00:00:00

  • Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis.

    abstract::We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respecti...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(01)00403-2

    authors: Yi JM,Hong SH,Kim JH,Kim HK,Song HJ,Kim HM

    更新日期:2002-03-01 00:00:00

  • Cytotoxic ethnic Yao medicine Baizuan, leaves of Schisandra viridis A. C. Smith.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The ethnic Chinese Yao medicine Baizuan, which are the leaves of Schisandra viridis A. C. Smith, is traditionally used, in combination with other herbs, to soften hard lumps and dispel nodes in the treatment of cancer, however, this property has not been well studied with a clear indicati...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.09.016

    authors: Hou X,Deng J,Zhang Q,Wang D,Kennedy D,Quinn RJ,Feng Y

    更新日期:2016-12-24 00:00:00

  • Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In agreement with ethnomedicinal reports, the dichloromethane extract of Ageratum conyzoides L. (Asteraceae) was recently shown to be of considerable activity against Trypanosoma brucei rhodesiense, the etiologic agent of East African Human Trypanosomiasis (East African Sleeping Sickness)...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.06.015

    authors: Harel D,Khalid SA,Kaiser M,Brun R,Wünsch B,Schmidt TJ

    更新日期:2011-09-01 00:00:00

  • Recent trends in research into African medicinal plants.

    abstract::Recent trends in research into African medicinal plants show that while ethnobotanical surveys continue, there is an appreciable increase in research activity in the area of bioactivity of natural products. The biological areas most researched include antimicrobial, molluscicidal, toxicity tests and antitumour in decr...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/0378-8741(93)90017-y

    authors: Sofowora A

    更新日期:1993-03-01 00:00:00

  • Puerarin attenuates glutamate-induced neurofilament axonal transport impairment.

    abstract:AIM OF THE STUDY:Puerarin (Pur) is a primary component of the most functional extracts of Pueraria lobata used in traditional Chinese medicine for centuries. Since it has been postulated that Pur protects the brain against glutamate (Glu) neurotoxicity, we investigated the effects of Pur on Glu-induced axonal transport...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.08.005

    authors: Zhou J,Wang H,Xiong Y,Li Z,Feng Y,Chen J

    更新日期:2010-10-28 00:00:00

  • Reverse ethnopharmacology and drug discovery.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ethnopharmacological investigations of traditional medicines have made significant contributions to plant-derived drugs, as well as the advancement of pharmacology. Drug discovery from medicinal flora is more complex than generally acknowledged because plants are applied for different the...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.12.044

    authors: Leonti M,Stafford GI,Cero MD,Cabras S,Castellanos ME,Casu L,Weckerle CS

    更新日期:2017-02-23 00:00:00

  • Inhibitory activity of Chrysanthemi sibirici herba extract on RBL-2H3 mast cells and compound 48/80-induced anaphylaxis.

    abstract::The effects of extracts from various oriental medicinal herbs on mast cell-mediated allergic reaction were investigated. Among them, Chrysanthemi sibirici herba ethanol extract exerted the potent inhibitory activity on antigen-induced degranulation in RBL-2H3 mast cells. Chrysanthemi sibirici herba dose-dependently in...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2004.08.023

    authors: Lee JH,Seo JY,Ko NY,Chang SH,Her E,Park T,Lee HY,Han JW,Kim YM,Choi WS

    更新日期:2004-12-01 00:00:00

  • Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Nymphaea hybrida Peck is used as a traditional medicinal herb for treating pain and inflammatory diseases, and known for its ornamental value and as a hot drink. However, the effects of N. hybrida polar fractions on lipopolysaccharide (LPS)-induced in vitro inflammation model and acute in...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113698

    authors: Zhang Z,Jiang S,Tian H,Zeng Y,He K,Lin L,Yu F

    更新日期:2021-04-06 00:00:00

  • Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae.

    abstract::The effects of Cordyceps cicadae extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that aqueous methanol (50%) extracts of C. cicadae ascocarps portion (CC-1-2) enhanced HMNC proliferation activated with phytohemagglutinin (PHA) wit...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(02)00212-x

    authors: Weng SC,Chou CJ,Lin LC,Tsai WJ,Kuo YC

    更新日期:2002-11-01 00:00:00

  • The composition and vascular/antioxidant properties of Taraxacum officinale flower water syrup in a normal-fat diet using an obese rat model.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity. AIM OF THE STUDY:Based on animal experiments this study aims to explore the potential mechan...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113393

    authors: Majewski M,Lis B,Juśkiewicz J,Ognik K,Jedrejek D,Stochmal A,Olas B

    更新日期:2021-01-30 00:00:00

  • Pharmacological basis for the medicinal use of muskmelon base (Pedicellus Melo.) for abdominal distention and constipation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Muskmelon base (Pedicellus Melo.) has a long history (Ming Dynasty) as a Chinese traditional medicine. According to traditional use, it was prepared as rectal suppositories for treating abdominal distention and constipation. The present study was carried out on the pharmacological basis f...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.04.025

    authors: Gao Y,Cai RL,Xie C,Lin YL,Zhang L,Qi Y

    更新日期:2012-06-26 00:00:00

  • Modified Si-Miao-San extract inhibits the release of inflammatory mediators from lipopolysaccharide-stimulated mouse macrophages.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Modified Si-Miao-San (mSMS) is a prescription modified from Si-Miao-San which is an ancient Chinese prescription used to treat various ailments. AIM OF THE STUDY:Modified Si-Miao-San (mSMS) has been used for the treatment of infectious and inflammatory disorders in the clinic. This study...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.02.002

    authors: Fan J,Liu K,Zhang Z,Luo T,Xi Z,Song J,Liu B

    更新日期:2010-05-04 00:00:00

  • Folk medical uses of plant foods in southern Appalachia, United States.

    abstract::An analysis of information obtained from interviews with 660 older native inhabitants of the southern Appalachian region in the United States indicates that plant foods, especially cultivars and materials processed from them, and some wildcrafted plant foods as well, constituted the bulk of the folk materia medica in ...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.jep.2006.04.008

    authors: Cavender A

    更新日期:2006-11-03 00:00:00

  • Metabolites and the pharmacokinetics of kobophenol A from Caragana sinica in rats.

    abstract::This research aims to study the metabolism and pharmacokinetics of phytoestrogen kobophenol A (1), the main active compound of Caragana sinica (Buc'hoz) Rehd. (Fabaceae), in rats. Metabolites of 1 in rats' feces were isolated and purified by multi-chromatograph techniques; three new metabolites of 1, named koboquinone...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.05.016

    authors: Liang GL,Bi JB,Huang HQ,Zhang S,Hu CQ

    更新日期:2005-10-03 00:00:00

  • Effect of Chinese herbal medicine on stroke patients with type 2 diabetes.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and st...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.02.024

    authors: Tsai FJ,Ho TJ,Cheng CF,Liu X,Tsang H,Lin TH,Liao CC,Huang SM,Li JP,Lin CW,Lin JG,Lin JC,Lin CC,Liang WM,Lin YJ

    更新日期:2017-03-22 00:00:00

  • Modulation of macrophage function activity by ethanolic extract of larvae of Holotrichia diomphalia.

    abstract::Macrophages play a central role in determining the host response to tumor, in part through the secretion of several potent products. In this study, our work is directed toward studying the in vitro effects of extract from the larvae of Holotrichia diomphalia (HD-EX) on the ability to induce cellular and secretory resp...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(01)00369-5

    authors: Kang NS,Park SY,Lee KR,Lee SM,Lee BG,Shin DH,Pyo S

    更新日期:2002-01-01 00:00:00

  • Snakebites and ethnobotany in the northwest region of Colombia: Part II: neutralization of lethal and enzymatic effects of Bothrops atrox venom.

    abstract::Twelve of 74 ethanolic extracts of plants used by traditional healers for snakebites in the northwest region of Colombia, were active against lethal effect of Bothrops atrox venom when they were i.p. injected into mice (18-20 g). After preincubation of sublethal doses of every extract (0.5-4.0 mg/mouse) with 1.5 i.p. ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(99)00197-x

    authors: Otero R,Núñez V,Jiménez SL,Fonnegra R,Osorio RG,García ME,Díaz A

    更新日期:2000-08-01 00:00:00

  • Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.07.036

    authors: Yeh CW,Liu HK,Lin LC,Liou KT,Huang YC,Lin CH,Tzeng TT,Shie FS,Tsay HJ,Shiao YJ

    更新日期:2017-09-14 00:00:00

  • Vasorelaxant action of an ethylacetate fraction of Euphorbia humifusa involves NO-cGMP pathway and potassium channels.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Euphorbia humifusa Willd. (EH) is an important traditional Chinese medicine that has commonly been used for treating bacillary dysentery and enteritis in many Asian countries for thousands of years. EH has a wide variety of pharmacological actions such as antioxidant, hypotensive, and hyp...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2013.05.025

    authors: Wang TT,Zhou GH,Kho JH,Sun YY,Wen JF,Kang DG,Lee HS,Cho KW,Jin SN

    更新日期:2013-07-09 00:00:00

  • Inhibitory effects of Saussurea involucrata (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Saussurea involucrate (Kar. et Kir.) Sch. -Bip is an endangered species of the Compositae family, and this species has long been used for the treatment of rheumatoid arthritis, dysmenorrhea, stomachache, and altitude sickness in Uighur folk and Chinese medicine. AIM OF THE STUDY:This stu...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.09.008

    authors: Han X,Su D,Xian X,Zhou M,Li X,Huang J,Wang J,Gao H

    更新日期:2016-12-24 00:00:00

  • RETRACTED: Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats.

    abstract:ETHNOPHARMACOLOGICALS RELEVANCE:Swertia corymbosa locally called as Shirattakuchi have a long history of use in Ayurveda herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM OF THE STUDY:The present study aimed to investigate the effect ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,收录出版

    doi:10.1016/j.jep.2013.12.032

    authors: Mahendran G,Thamotharan G,Sengottuvelu S,Narmatha Bai V

    更新日期:2014-02-12 00:00:00