当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

Abstract：

AIM OF THE STUDY:Rhei Rhizoma, the rhizome of Rheum palmatum L. (RP), is a popular herb in clinical Chinese medicine. RP is abundant in polyphenolic anthraquinones, which have been reported to show various beneficial bioactivities. This study investigated the pharmacokinetics and tissue distribution of anthraquinones following seven-dose administration of RP decoction to rats. MATERIALS AND METHODS:Six Sprague-Dawley rats were given 2.0 g/kg of RP twice daily for seven doses and blood samples were collected at designated time after the 7th dose. Another six rats were sacrificed at 30 min after the 7th dose and organs including liver, kidney, lung and brain were collected. Serum and tissue specimens were assayed by HPLC before and after hydrolysis with β-glucuronidase and sulfatase, respectively. RESULTS:Pharmacokinetic analysis indicated that the anthraquinones in serum mainly presented as glucuronides/sulfates and contained higher ratio of sulfates when compared with single-dose administration of RP. Contrary to the finding in serum, tissue analysis discovered mainly free form of anthraquinone in most organs assayed, such as aloe-emodin and rhein in kidney, liver, lung; emodin in liver, lung; trace of chrysophanol in kidney and liver. In all brains, neither free forms nor their glucuronides/sulfates have been detected. CONCLUSIONS:The glucuronides/sulfates of anthraquinones were the major forms in bloodstream, whereas the free forms of most anthraquinones were predominant in kidney and liver.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Shia CS,Tsai SY,Lin JC,Li ML,Ko MH,Chao PD,Huang YC,Hou YC

doi

10.1016/j.jep.2011.08.003

subject

Has Abstract

pub_date

2011-10-11 00:00:00

pages

1388-94

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00567-8

journal_volume

137

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Anti-inflammatory and analgesic activity in the polyherbal formulation Maharasnadhi Quathar.

    abstract：:Maharasnadhi Quathar (MRQ) is a polyherbal preparation recommended by Ayurvedic medical practitioners for treatment of arthritic conditions. An investigation has been carried out with rats and human rheumatoid arthritis (RA) patients, to determine the anti-inflammatory and analgesic potential of MRQ. Results obtained ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00016-3

    authors： Thabrew MI,Dharmasiri MG,Senaratne L

    更新日期：2003-04-01 00:00:00

  • Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Withania somnifera root extract (Ws)/Ashwagandha/Indian ginseng is a traditional herbal medicine, used over 4000 years in India, shown to have effect on neural growth and locomotor function. Although catecholamines and oxidative stress resulting in neurodegeneration and locomotor disorder...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.08.003

    authors： RajaSankar S,Manivasagam T,Sankar V,Prakash S,Muthusamy R,Krishnamurti A,Surendran S

    更新日期：2009-09-25 00:00:00

  • Evaluation of the mutagenic and antimutagenic effects of South African plants.

    abstract：:Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.030

    authors： Reid KA,Maes J,Maes A,van Staden J,De Kimpe N,Mulholland DA,Verschaeve L

    更新日期：2006-06-15 00:00:00

  • Maimendong and Qianjinweijing Tang (Jin formula) suppresses lung cancer by regulation of miR-149-3p.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Maimendong and Qianjinweijing Tang (Jin formula), a classic Chinese formula, can enhance therapeutic efficacy and reduce adverse effects in patients with lung cancer. AIM OF THE STUDY:To evaluate the anti-lung cancer effect of Jin formula in vivo and in vitro, and to explore the role of ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112836

    authors： Jiang Z,Ma Y,Tian T,Sun Y,Chen H,Lu Y,Wu Y,Jiang H,Li W,Li L,Zhou H,Wu M

    更新日期：2020-08-10 00:00:00

  • Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Xiao-Ban-Xia-Tang (XBXT), a traditional Chinese herbal medicine, has been used in China for more than 2000 years, and proved to be effective on various cases of vomiting in the clinic. OBJECTIVE:To investigate the antiemetic effect of XBXT on cisplatin-induced acute and delayed emesis an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.01.027

    authors： Qian Q,Chen W,Yue W,Yang Z,Liu Z,Qian W

    更新日期：2010-04-21 00:00:00

  • Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Eerdun Wurile (EW) is one of the key Mongolian medicines for treatment of neurological and cardiological disorders. EW is ranked most regularly used Mongolian medicine in clinic. Components of EW which mainly originate from natural products are well defined and are unique to Mongolian med...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.05.011

    authors： Gaowa S,Bao N,Da M,Qiburi Q,Ganbold T,Chen L,Altangerel A,Temuqile T,Baigude H

    更新日期：2018-08-10 00:00:00

  • Influence of aqueous extract from Neurada procumbens L. on blood pressure of rats.

    abstract：:Neurada procumbens is a desert plant in the Arabian Peninsula. It has been considered edible by Bedouin and has been used traditionally as a medicinal herb. During a screening test of Arabian plants, the aqueous extract of Neurada procumbens increased the blood pressure of anaesthetized normotensive rats when it was a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.09.045

    authors： Chen HB,Islam MW,Radhakrishnan R,Wahab SA,Naji MA

    更新日期：2004-02-01 00:00:00

  • Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain injury in mice by restoration of cerebrovascular function.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Duoxuekang (DXK, ཁྲག་འཕེལ་བདེ་བྱེད།) is a clinical experience prescription of CuoRu-Cailang, a famous Tibetan medicine master, which has effective advantages in the treatment of hypobaric hypoxia (HH)-induced brain injury. However, its underlying mechanisms remain unclear. AIM OF THE STU...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113629

    authors： Li N,Chen K,Bai J,Geng Z,Tang Y,Hou Y,Fan F,Ai X,Hu Y,Meng X,Wang X,Zhang Y

    更新日期：2020-11-25 00:00:00

  • Evaluation of the anthelminthic potential of Duranta erecta L. (Verbenaceae) fruits used in Nigerian ethnomedicine as a vermifuge.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Duranta erecta L. fruits have been reported to have in vitro anthelminthic properties. People living in the tropical South-Eastern part of Nigeria use the plant in folk medicine for the treatment of malaria, abscesses and as a vermifuge. Although there are a few reports about its in vitro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.01.030

    authors： Udobi MI,Nzeakor TA,Eke IG,Ezeh IO,Onyeabor A,Idika IK,Nwosu CO

    更新日期：2018-04-24 00:00:00

  • The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Salvia miltiorrhiza, a perennial plant in the genus Salvia and popularly known as "Danshen", is highly valued for its roots in traditional Chinese medicines (TCMs). It has widely used for the treatment of cerebrovascular and cardiovascular diseases in China. Recently, the cerebral protect...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.12.048

    authors： Cao ZQ,Quan W,Hou SX,Guo C,Ma SB,Zhang W,Li X

    更新日期：2015-03-13 00:00:00

  • Modulation of biochemical parameters by Hemidesmus indicus in cumene hydroperoxide-induced murine skin: possible role in protection against free radicals-induced cutaneous oxidative stress and tumor promotion.

    abstract：:Hemidesmus indicus has been shown to possess significant activity against immunotoxicity and other pharmacological and physiological disorders. In this communication, we have shown the modulating effect of H. indicus on cumene hydroperoxide-mediated cutaneous oxidative stress and tumor promotion response in murine ski...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00360-4

    authors： Sultana S,Khan N,Sharma S,Alam A

    更新日期：2003-03-01 00:00:00

  • Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Celtis iguanaea (Canabaceae) is popularly known as esporão-de-galo, stands out among the medicinal plants used for treatment of gastric ulcers. In Brazil, the leaves they are used traditionally in infusion forms as an analgesic, antiasthmatic, digestive and diuretic. AIM OF THE STUDY:The...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.08.006

    authors： Martins JL,Rodrigues OR,da Silva DM,Galdino PM,de Paula JR,Romão W,da Costa HB,Vaz BG,Ghedini PC,Costa EA

    更新日期：2014-09-29 00:00:00

  • Pristimerin isolated from Salacia crassifolia (Mart. Ex. Schult.) G. Don. (Celastraceae) roots as a potential antibacterial agent against Staphylococcus aureus.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pristimerin is a triterpenoid considered the main component of Salacia crassifolia extracts. This terpene has shown promising antitumor, anti-inflammatory, and antimicrobial effects. Likewise, S. crassifolia has been used in traditional medicine to treat cancer and as an antimicrobial and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113423

    authors： Nizer WSDC,Ferraz AC,Moraes TFS,Lima WG,Santos JPD,Duarte LP,Ferreira JMS,de Brito Magalhães CL,Vieira-Filho SA,Andrade ACDSP,Rodrigues RAL,Abrahão JS,Magalhães JC

    更新日期：2021-02-10 00:00:00

  • Plants in treating senile dementia in the northwest Amazon.

    abstract：:The Indians of the northwest Amazon respect age and try to care for those suffering from senile dementia. At least 25 species of plants are employed in treating Alzheimer's disease or similar problems. The plants are administered orally as teas of the leaves or roots and over a period of several days to numerous weeks...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(93)90007-r

    authors： Schultes RE

    更新日期：1993-03-01 00:00:00

  • Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation.

    abstract：AIM OF THE STUDY:To investigate the cardioprotective potential of Syringa pinnatifolia Hems1. var. alashanensis essential oil (SPEO) against experimental acute myocardial ischemia (AMI), hydrogen peroxide (H(2)O(2))-induced myocyte injury and activities against hypoxia and platelet aggregation. MATERIALS AND METHODS:W...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.06.027

    authors： Yan Y,O W,Zhao X,Ye X,Zhang C,Hao J,He J,Zhu X,Xu H,Yang X

    更新日期：2010-09-15 00:00:00

  • Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells.

    abstract：AIM OF THE STUDY:Ardisia species, notably A. compressa, are used in some regions of the world as food or in traditional medicine for prevention and treatment of certain health conditions including liver disease. We investigated the chemical composition and relative anticancer potential of six Ardisia species [A. japoni...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.051

    authors： Newell AM,Yousef GG,Lila MA,Ramírez-Mares MV,de Mejia EG

    更新日期：2010-08-09 00:00:00

  • Neuroprotection, learning and memory improvement of a standardized extract from Renshen Shouwu against neuronal injury and vascular dementia in rats with brain ischemia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Renshen Shouwu capsule (RSSW) is a patented Traditional Chinese Medicine (TCM), that has been proven to improve memory and is widely used in China to apoplexy syndrome and memory deficits. To investigate the neuroprotective and therapeutic effect of the Renshen Shouwu standardized ext...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.02.027

    authors： Wan L,Cheng Y,Luo Z,Guo H,Zhao W,Gu Q,Yang X,Xu J,Bei W,Guo J

    更新日期：2015-05-13 00:00:00

  • Traditional detoxification of Jatropha curcas L. seeds.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Jatropha curcas L. is a plant with high cultural significance for quilombola communities of Oriximiná (Pará State, Brazil). Although the plant is highly toxic, its seeds are used in these communities to treat tuberculosis and related diseases and symptoms. AIM OF THE STUDY:This study was...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.111970

    authors： Albino RC,Antoniassi R,de Faria-Machado AF,Ferraris FK,Amendoeira FC,Ramos DF,Silva PEA,Leitão SG,Oliveira DR

    更新日期：2019-09-15 00:00:00

  • Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:As a well-known traditional Chinese medicine the root bark of Aralia taibaiensis has traditionally been used as the medicine considered alleviating several disorders including diabetes mellitus (DM). Chikusetsu saponin IVa (CHS) has been defined as a major active ingredient of triterpenoi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.02.032

    authors： Cui J,Xi MM,Li YW,Duan JL,Wang L,Weng Y,Jia N,Cao SS,Li RL,Wang C,Zhao C,Wu Y,Wen AD

    更新日期：2015-04-22 00:00:00

  • The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine, processed aconite root (lateral root of Aconitum carmichaelii Debx.) is used as the principle herb of the Si-Ni decoction (SND) formula due to its cardiotonic effect, while its cardiotoxicity and neurotoxicity caused by diester and monoester diterpenoid al...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.09.022

    authors： Zhang M,Peng Y,Wang M,Gao B,Zhao L,Li X

    更新日期：2019-01-10 00:00:00

  • Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats.

    abstract：PHARMACOLOGICAL RELEVANCE:Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions. AIM OF THE STUDY:Lack of scientific data for potential use in bone loss, the present study w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.01.031

    authors： Desai S,Babaria P,Nakarani M,Shah K,Paranjape A

    更新日期：2017-03-06 00:00:00

  • Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats.

    abstract：:The effects of using Bauhinia forficata leaf decoction (150 g leaf/l water; 35.2+/-7.8 ml/100 g body weight mean daily dose) as a drinking-water substitute for about 1 month on streptozotocin-diabetes (STZ-diabetes) in male Wistar rats were investigated. The physico-metabolic parameters measured were: body weight, foo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00075-2

    authors： Pepato MT,Keller EH,Baviera AM,Kettelhut IC,Vendramini RC,Brunetti IL

    更新日期：2002-07-01 00:00:00

  • In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice.

    abstract：:Extracts obtained from two Burkinabe folk medicine plants, spiny amaranth (Amaranthus spinosus L., Amaranthaceae) and erect spiderling (Boerhaavia erecta L., Nyctagynaceae) were screened for antimalarial properties with the aim of testing the validity of their traditional uses. The plant extracts showed significant an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.006

    authors： Hilou A,Nacoulma OG,Guiguemde TR

    更新日期：2006-01-16 00:00:00

  • Dual mechanisms of a Sri Lankan traditional polyherbal mixture in the improvement of pancreatic beta cell functions and restoration of lipoprotein alterations in streptozotocin induced diabetic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional polyherbal preparations have been utilized in Sri Lanka since ancient times and have gained a wide acceptance throughout the country. Although an extensive body of evidence supports the use of traditional herbal mixtures in the treatment of diabetes mellitus, only a few polyhe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113613

    authors： Liyanagamage DSNK,Jayasinghe S,Attanayake AP,Karunaratne V

    更新日期：2021-03-01 00:00:00

  • Biological effect of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. Note I: diuretic activity.

    abstract：:In this work we studied in rat the diuretic activity of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. The cladodes, flowers and non commerciable fruits were collected in S. Cono (CT, Sicily) cultivation. Acute and chronic diuretic activity of 15% infusion of cladodes, flowers and fruits were assayed. Natri...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00337-3

    authors： Galati EM,Tripodo MM,Trovato A,Miceli N,Monforte MT

    更新日期：2002-01-01 00:00:00

  • Huperzia saururus Lam. Trevis. (Lycopodiaceae) facilitates ejaculation in spinal cord transected male rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Huperzia saururus (Lam.) Trevis. has an extensive ethnopharmacological use, mainly because of its aphrodisiac properties. The species is consumed as decoctions or infusions in traditional medicine. The purpose of the present research was to determine if Huperzia saururus is able to increa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.016

    authors： Birri MA,Franco MA,Vallejo MG,Carro-Juárez M,Agnese AM

    更新日期：2014-11-18 00:00:00

  • High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Radix Angelica dahuricae (RAD), the roots of Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav, is a well-known traditional Chinese medicine (TCM) and has been used for centuries to treat headaches, toothaches, nose congestion, abscesses, furunculoses, and acne. This herb is al...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.10.014

    authors： Chen L,Yang H,Yu C,Yuan M,Li H

    更新日期：2018-02-15 00:00:00

  • Analysis of gossypol by high performance liquid chromatography.

    abstract：:Several high performance liquid chromatographic methods for the analysis of gossypol in different kinds of sample were developed. (1) Pure gossypol: separation on C18 column with MeOH/H2O/CHCl3 (70:30:40) containing 0.1% H3PO4 as mobile phase or on SO3H column with MeOH/citrate buffer (pH 6.3) (55:45) as mobile phase ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(87)90112-7

    authors： Wang MZ

    更新日期：1987-06-01 00:00:00

  • A review of pharmacological and clinical studies on the application of Shenling Baizhu San in treatment of Ulcerative colitis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The prescription of Shenling Baizhu San (SLBZS) was derived from the Song Dynasty "Taiping Huimin Heji Ju Fang", which was a representative prescription for treating spleen asthenic diarrhea. The prescription comprised of 10 herbs for treating weak spleen and stomach. It describes symptom...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112105

    authors： Ma Q,Ouyang Y,Meng F,Noolvi MN,Avvaru SP,More UA,Aminabhavi TM,Du M,Liu H,Zhuang Y,Pang M,Cai T,Cai Y

    更新日期：2019-11-15 00:00:00

  • Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Eugenia species are widely used in popular medicine to treat several diseases, such as arthritis, rheumatism and diabetes. Eugenia umbelliflora O. Berg is popularly known in Brazil as "baguaçu", name also conferred to Eugenia jambolana probably due to their apparent similari...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112133

    authors： Goldoni FC,Barretta C,Nunes R,Broering MF,De Faveri R,Molleri HT,Corrêa TP,Farias IV,Amorin CK,Pastor MVD,Meyre-Silva C,Bresolin TMB,de Freitas RA,Quintão NLM,Santin JR

    更新日期：2019-11-15 00:00:00