In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice.

Abstract:

:Extracts obtained from two Burkinabe folk medicine plants, spiny amaranth (Amaranthus spinosus L., Amaranthaceae) and erect spiderling (Boerhaavia erecta L., Nyctagynaceae) were screened for antimalarial properties with the aim of testing the validity of their traditional uses. The plant extracts showed significant antimalarial activities in the 4-day suppressive antimalarial assay in mice inoculated with red blood cells parasitized with Plasmodium berghei berghei. We obtained values for ED(50) of 789 and 564 mg/kg for Amaranthus spinosus and Boerhaavia erecta extracts, respectively. Moreover the tested vegetal material showed only low toxicity (1,450 and 2,150 mg/kg as LD(50) for Amaranthus spinosus and Boerhaavia erecta, respectively).

journal_name

J Ethnopharmacol

authors

Hilou A,Nacoulma OG,Guiguemde TR

doi

10.1016/j.jep.2005.08.006

keywords:

subject

Has Abstract

pub_date

2006-01-16 00:00:00

pages

236-40

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00508-8

journal_volume

103

pub_type

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