当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Celosia argentea L. (Amaranthaceae) a vasodilator species from the Brazilian Cerrado - An ethnopharmacological report.

Celosia argentea L. (Amaranthaceae) a vasodilator species from the Brazilian Cerrado - An ethnopharmacological report.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Celosia argentea L. (Amaranthaceae), popularly known as "crista de galo", is used in folk medicine due to its diuretic and hypotensive effects. However, there are no reports in the literature regarding its pharmacological effects on the cardiovascular system as well as no data proving the safety of this species. AIM:To perform a detailed ethnopharmacological investigation of the ethanol soluble fraction from C. argentea (ESCA) using male and female Wistar rats. MATERIAL AND METHODS:Firstly, a morpho-anatomical characterization was performed to determine the quality control parameters for the identification of the species under investigation. Then, the ethanol extract was obtained and chemically characterized by LC-DAD-MS. Furthermore, an oral acute toxicity study was performed in female Wistar rats. Finally, the possible diuretic and hypotensive effects of three different doses of ESCA (30, 100 and 300 mg/kg) were evaluated in male Wistar rats. Besides, the vasodilatory response of ESCA in mesenteric vascular beds (MVBs) and its involvement with nitric oxide/cGMP and prostaglandin/cAMP pathways as well as potassium channels were evaluated. RESULTS:The main secondary metabolites present in ESCA were phenolic compounds, megastigmanes and triterpenoid saponins. ESCA caused no toxic effects in female rats nor increased urinary excretion in male rats after acute administration. However, ESCA significantly increased the renal elimination of potassium and chloride, especially at the end of 24 h after administration. Intermediary dose (100 mg/kg) of ESCA was able to promote significant acute hypotension and bradycardia. Moreover, its cardiovascular effects appear to be involved with the voltage-dependent K+ channels activation in MVBs. CONCLUSION:This study has brought new scientific evidence of preclinical efficacy of C. argentea as a hypotensive agent in normotensive rats. Apparently, these effects are involved with the activation of the voltage-sensitive K+ channels contributing to the reduction of peripheral vascular resistance and cardiac output.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Tolouei SEL,Tirloni CAS,Palozi RAC,Schaedler MI,Guarnier LP,Silva AO,de Almeida VP,Budel JM,Souza RIC,Dos Santos AC,Dos Santos VS,Silva DB,Dalsenter PR,Gasparotto Junior A

doi

10.1016/j.jep.2018.09.027

subject

Has Abstract

pub_date

2019-01-30 00:00:00

pages

115-126

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(18)32093-2

journal_volume

229

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • In-vitro (2D and 3D cultures) and in-vivo cytotoxic properties of Zataria multiflora essential oil (ZEO) emulsion in breast and cervical cancer cells along with the investigation of immunomodulatory potential.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zataria multiflora is an iranian valuable traditional plants, called Avishan Shirazi in Persian language used to reduce inflammation, spasm, pain, and cancer symptoms. Zataria essential oil (ZEO) is one of the essential oils possessing broad biological activities. AIM OF THE STUDY:The ai...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112865

    authors： Azadi M,Jamali T,Kianmehr Z,Kavoosi G,Ardestani SK

    更新日期：2020-07-15 00:00:00

  • Biological effect of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. Note I: diuretic activity.

    abstract：:In this work we studied in rat the diuretic activity of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. The cladodes, flowers and non commerciable fruits were collected in S. Cono (CT, Sicily) cultivation. Acute and chronic diuretic activity of 15% infusion of cladodes, flowers and fruits were assayed. Natri...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00337-3

    authors： Galati EM,Tripodo MM,Trovato A,Miceli N,Monforte MT

    更新日期：2002-01-01 00:00:00

  • Influence of aqueous extract from Neurada procumbens L. on blood pressure of rats.

    abstract：:Neurada procumbens is a desert plant in the Arabian Peninsula. It has been considered edible by Bedouin and has been used traditionally as a medicinal herb. During a screening test of Arabian plants, the aqueous extract of Neurada procumbens increased the blood pressure of anaesthetized normotensive rats when it was a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.09.045

    authors： Chen HB,Islam MW,Radhakrishnan R,Wahab SA,Naji MA

    更新日期：2004-02-01 00:00:00

  • Inhibitory effects of Saussurea involucrata (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Saussurea involucrate (Kar. et Kir.) Sch. -Bip is an endangered species of the Compositae family, and this species has long been used for the treatment of rheumatoid arthritis, dysmenorrhea, stomachache, and altitude sickness in Uighur folk and Chinese medicine. AIM OF THE STUDY:This stu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.008

    authors： Han X,Su D,Xian X,Zhou M,Li X,Huang J,Wang J,Gao H

    更新日期：2016-12-24 00:00:00

  • Are meta-analyses of Chinese herbal medicine trials trustworthy and clinically applicable? A cross-sectional study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Meta-analysis (MA) on Chinese herbal medicine (CHM) trials is increasingly published and indexed in major international databases but their trustworthiness and clinical applicability is uncertain. We aimed to assess the characteristics and methodological quality of MA on CHM. MATERIALS A...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2014.12.028

    authors： Chung VC,Ho RS,Wu X,Fung DH,Lai X,Wu JC,Wong SY

    更新日期：2015-03-13 00:00:00

  • The comparative phytochemistry of the genus Erythroxylon.

    abstract：:Recent research suggests that, in addition to the well-documented occurrence of significant quantities of cocaine and related alkaloids in a limited number of species, the genus Erythroxylon will prove to be a rich source of tropane alkaloids. These bases are esters of a range of acids with tropine, 3 alpha, 6 beta-di...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(81)90057-x

    authors： Evans WC

    更新日期：1981-03-01 00:00:00

  • Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.014

    authors： Santin JR,Lemos M,Klein Júnior LC,Niero R,de Andrade SF

    更新日期：2010-07-20 00:00:00

  • Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila.

    abstract：AIM OF THE STUDY:Labisia pumila has rejuvenating properties that help women to regain the strength and vigour after giving birth (Burkill, 1935) leading us to speculate that Labisia pumila might also modulate the immune matrix as it is one of the important aspect of healthy state of the living body. MATERIALS AND METH...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.039

    authors： Pandey A,Bani S,Sangwan P,Koul S

    更新日期：2010-10-28 00:00:00

  • RETRACTED: Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats.

    abstract：ETHNOPHARMACOLOGICALS RELEVANCE:Swertia corymbosa locally called as Shirattakuchi have a long history of use in Ayurveda herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM OF THE STUDY:The present study aimed to investigate the effect ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.jep.2013.12.032

    authors： Mahendran G,Thamotharan G,Sengottuvelu S,Narmatha Bai V

    更新日期：2014-02-12 00:00:00

  • Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Rhizoma alismatis (simplified as RA, "Zexie" in Chinese, ) is a well-known natural medicine with long history in Chinese medicine. As a traditional medicine in China, RA is an important part of many prescriptions and has been commonly used for treating a wide range of ailments related to ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2014.10.061

    authors： Tian T,Chen H,Zhao YY

    更新日期：2014-12-02 00:00:00

  • Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of Casimiroa edulis (AECe) on rat mesenteric arterial bed.

    abstract：:The vasorelaxing activity of the aqueous extracts of Casimiroa edulis seeds F(AECe) on mesenteric arterial bed (MAB) of rats was studied. MAB precontracted with methoxamine was mounted on a tissue bath and exposed to plant extracts (bolus 50, 500, 2500 and 5000 microg). The bolus injections of AECe significantly inhib...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.06.018

    authors： Baisch AL,Urban H,Ruiz AN

    更新日期：2004-12-01 00:00:00

  • Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC-MS/MS.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Astragali radix is one of the well-known traditional Chinese herbal medicine, and possesses various biological functions, such as hepatoprotective and anticancer. In present study, to investigate the metabolism and pharmacokinetics of the major constituents of A. radix, a sensitive ultra-...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.019

    authors： Shi J,Zheng L,Lin Z,Hou C,Liu W,Yan T,Zhu L,Wang Y,Lu L,Liu Z

    更新日期：2015-07-01 00:00:00

  • Matrix degradation inhibitory effect of Schisandra fructus on human articular cartilage and chondrocytes.

    abstract：:The purpose of this study is to assess the protective effects exerted by Schisandra fructus (SF) on hyaluronidase (HAase) and the recombinant human interleukin-1beta (IL-1beta) induced matrix degradation in human articular cartilage and chondrocytes. The effect of SF on the matrix gene expression of immortalized chond...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.12.018

    authors： Choi SI,Park SR,Heo TR

    更新日期：2006-06-30 00:00:00

  • Acute toxicity, antinociceptive activity and indole alkaloids of aqueous extract from bark of Aspidosperma cuspa (Kunth) Blake.

    abstract：UNLABELLED:ETNOPHARMACOLOGICAL RELEVANCE: Aspidosperma cuspa (Kunth) Blake (Apocynaceae) is popularly known as "amargosa" or "cuspa", and its bark is used in folk medicine primarily for pain. AIM OF THE STUDY:In the present study the acute toxicity, antinociceptive effect and alkaloids of the aqueous decoction extract...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.021

    authors： Pérez NM,Torrico FB,Morales A

    更新日期：2012-09-28 00:00:00

  • The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).

    abstract：:The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies. The hexane extract of this plant was evaluated for cytotoxic activity against in vitro culture on P388 murine leukaemia cells and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00274-4

    authors： Choo CY,Chan KL,Sam TW,Hitotsuyanagi Y,Takeya K

    更新日期：2001-09-01 00:00:00

  • Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice.

    abstract：:The effects of daily administration of Withania somnifera root extract (1.4 g/kg body wt.) and Bauhinia purpurea bark extract (2.5 mg/kg body wt.) for 20 days on thyroid function in female mice were investigated. While serum triiodothyronine (T3) and thyroxine (T4) concentrations were increased significantly by Bauhin...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00018-5

    authors： Panda S,Kar A

    更新日期：1999-11-01 00:00:00

  • Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: In vitro and in vivo studies.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Maytenus robusta Reissek (Celastraceae) is traditionally used in Brazilian folk medicine to treat gastric ulcer, as a substitute for M. ilicifolia, which is almost extinct. The gastroprotective properties of M. robusta were demonstrated previously using only preventive approaches, such as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.09.006

    authors： da Silva LM,Boeing T,Somensi LB,Cury BJ,Steimbach VM,Silveria AC,Niero R,Cechinel Filho V,Santin JR,de Andrade SF

    更新日期：2015-12-04 00:00:00

  • Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Artemisia princeps Pampanini is widely used in Eastern traditional medicine for the treatment of circulatory disorders, such as, dysmenorrhea, hematuria, hemorrhoids, and inflammation, and is also used to treat chronic conditions, such as, cancers, ulcers, and digestive disorders. AIM OF...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.011

    authors： Ju HK,Lee HW,Chung KS,Choi JH,Cho JG,Baek NI,Chung HG,Lee KT

    更新日期：2012-05-07 00:00:00

  • Medicinal plants of the Popoluca, México: organoleptic properties as indigenous selection criteria.

    abstract：:The taste and smell of the environment are important to humans in everyday life and are of particular relevance for the selection of medicinal versus non-medicinal plant species. In a 16-months study with the Popoluca of southern Veracruz (Mexico), we focused on the indigenous selection criteria for medicinal plants. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00078-8

    authors： Leonti M,Sticher O,Heinrich M

    更新日期：2002-08-01 00:00:00

  • Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots.

    abstract：ETHNOPHARMACOLOGICAL IMPORTANCE:Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications. AIM OF THE STUDY:To assess the potentials of roo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.02.002

    authors： Sulyman AO,Akolade JO,Sabiu SA,Aladodo RA,Muritala HF

    更新日期：2016-04-22 00:00:00

  • Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice.

    abstract：:Previously, we demonstrated that Moutan Cortex prevents acetaminophen (AAP)-induced cytotoxicity in vitro. The present study examined the protective effect of Moutan Cortex on AAP induced hepatotoxicity and the possible mechanisms underlying this effect in mice. When Montan Cortex was administered to ICR mice, followe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.11.004

    authors： Shon YH,Nam KS

    更新日期：2004-02-01 00:00:00

  • Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells.

    abstract：AIM OF THE STUDY:Salvianolic-acid B (SA-B) is an effective component of Radix Salviae miltiorrhizae for anti-hepatic fibrotic herbs. MAPK signaling pathway has been implicated in hepatic stellate cells (HSC) stimulated by TGF-(1. We have investigated the effect of SA-B on MAPK pathway in rat HSC. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.026

    authors： Lv Z,Song Y,Xue D,Zhang W,Cheng Y,Xu L

    更新日期：2010-11-11 00:00:00

  • Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Heliopsis longipes (A. Gray) Blake (Asteraceae) is a broadly used species in the Mexican, Central and South American Traditional Medicine for its anaesthetic, analgesic, anti-inflammatory and anti-ulcerative properties. The ethanolic extract contains alkamides, mainly affinin (spilanthol)...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.060

    authors： Hernández I,Márquez L,Martínez I,Dieguez R,Delporte C,Prieto S,Molina-Torres J,Garrido G

    更新日期：2009-07-30 00:00:00

  • Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Postmenopausal osteoporosis is the most common bone disease worldwide. Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking. AIM OF THIS STUDY:This study was designed to investigate the effects of Du-Huo-Ji-Sheng-Tang (DHJ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.011

    authors： Wang JY,Chen WM,Wen CS,Hung SC,Chen PW,Chiu JH

    更新日期：2017-02-23 00:00:00

  • Therapeutic effect of Mahaenggamseok-tang on neutrophilic lung inflammation is associated with NF-κB suppression and Nrf2 activation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Mahaenggamseok-tang (MHGST), an herbal formula in traditional Asian medicine, has been used to treat patients with various pulmonary diseases including common cold and influenza. However, the potential therapeutic effect of MHGST on acute lung injury (ALI), a leading cause of death worldw...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.040

    authors： Kim KH,Lee JY,Kwun MJ,Choi JY,Han CW,Ha KT,Jeong SI,Jeong HS,Joo M

    更新日期：2016-11-04 00:00:00

  • SDF7, a group of Scoparia dulcis Linn. derived flavonoid compounds, stimulates glucose uptake and regulates adipocytokines in 3T3-F442a adipocytes.

    abstract：ETHNOPHARMACOLOGY RELEVANCE:Adipocytes are major tissues involved in glucose uptake second to skeletal muscle and act as the main adipocytokines mediator that regulates glucose uptake mechanism and cellular differentiation. The objective of this study were to examine the effect of the SDF7, which is a fraction consists...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.09.001

    authors： Beh JE,Khoo LT,Latip J,Abdullah MP,Alitheen NB,Adam Z,Ismail A,Hamid M

    更新日期：2013-10-28 00:00:00

  • Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Multi-target therapeutics is a promising paradigm for drug discovery which is expected to produce greater levels of efficacy with fewer adverse effects and toxicity than monotherapies. Medical herbs featuring multi-components and multi-targets may serve as valuable resources for network-b...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.07.001

    authors： Li P,Chen J,Wang J,Zhou W,Wang X,Li B,Tao W,Wang W,Wang Y,Yang L

    更新日期：2014-01-01 00:00:00

  • Polarity of extracts and fractions of four Combretum (Combretaceae) species used to treat infections and gastrointestinal disorders in southern African traditional medicine has a major effect on different relevant in vitro activities.

    abstract：ETHNOPHARMACOLOGICAL IMPORTANCE:Gastrointestinal disorders and infections are the major pathoaetiologies of diarrhoea causing many problems in human health and animal production. Many Combretum species are used in traditional medicine to treat infectious diseases including diarrhoea and many other ailments by rural peo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.03.030

    authors： Ahmed AS,McGaw LJ,Elgorashi EE,Naidoo V,Eloff JN

    更新日期：2014-06-11 00:00:00

  • Anticholinergic action of Swertia japonica and an active constituent.

    abstract：:The anticholinergic action of Swertia japonica, used in Japan as a bitter stomachic, was examined using in vivo experiments in rats in order to substantiate the presence or absence of antispasmodic properties. The methanol extract of Swertia japonica was found to be an effective anticholinergic given orally. Fractiona...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90157-9

    authors： Yamahara J,Kobayashi M,Matsuda H,Aoki S

    更新日期：1991-05-01 00:00:00

  • Neuropharmacological screening of Diospyros mespiliformis in mice.

    abstract：:The neuropharmacological activities of the aqueous extract of Diospyros mespiliformis stem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00249-0

    authors： Adzu B,Amos S,Muazzam I,Inyang US,Gamaniel KS

    更新日期：2002-11-01 00:00:00