当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice.

Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice.

Abstract：

:Previously, we demonstrated that Moutan Cortex prevents acetaminophen (AAP)-induced cytotoxicity in vitro. The present study examined the protective effect of Moutan Cortex on AAP induced hepatotoxicity and the possible mechanisms underlying this effect in mice. When Montan Cortex was administered to ICR mice, followed by hepatotoxic dose of AAP (400 mg/kg, i.p.), Moutan Cortex pre-exposure prevented liver injury as indicated by the decrease of serum alanine aminotransferase level. Moutan Cortex also protected AAP-induced hepatic glutathione depletion. Cytochrome P450 2E1-dependent aniline and p-nitrophenol hydroxylases activities in microsomal incubations were significantly inhibited by Moutan Cortex. Abrogation of toxicity was also mirrored in DNA fragmentation. These observations demonstrate that Moutan Cortex pre-exposure may attenuate AAP-induced GSH depletion, cytochrome P450 2E1 activity, and hepatic DNA damage in vivo.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Shon YH,Nam KS

doi

10.1016/j.jep.2003.11.004

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

415-9

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874103004136

journal_volume

90

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kanglaite (KLT) is an active extract of the Coix lacryma-jobi seed, which can benefit Qi and nourish Yin, and disperse the accumulation of evils. It is used as a biphasic broad-spectrum anti-cancer drug, and shows synergistic effects with radiotherapy and chemotherapy. However, the mechan...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113388

    authors： Chen C,Ai QD,Wei YH

    更新日期：2021-01-10 00:00:00

  • Sulphorhodamine B assay for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of crude drugs used in the treatment of vitiligo.

    abstract：:A rapid 96-well plate assay using sulphorhodamine B (SRB) protein stain for cell number has been adopted to screen herbs used in traditional treatments of vitiligo for substances capable of stimulating melanocyte proliferation. Its applicability to melan-a cells, a mouse pigmented cell line, has been validated. SRB as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00199-8

    authors： Lin ZX,Hoult JR,Raman A

    更新日期：1999-08-01 00:00:00

  • The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tetrastigma hemsleyanum Diels et Gilg, known as Sanyeqing in China, was an extensively used folk Chinese herbal medicine. This plant had been validated to be highly effective for treating high fever, pneumonia, hepatitis, gastritis, cervicitis, lymphatic tuberculosis, septicemia, and vira...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113836

    authors： Hu W,Zheng Y,Xia P,Liang Z

    更新日期：2021-01-16 00:00:00

  • In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In African traditional medicine, Ageratum conyzoides has been used as purgative, febrifuge, anti-ulcer and wound dressing. To date there is no safety information about long term use of Ageratum conyzoides which contains pyrrolizidine alkaloids, a class of hepatotoxic and carcinogenic phyt...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.07.005

    authors： Diallo A,Eklu-Gadegbeku K,Amegbor K,Agbonon A,Aklikokou K,Creppy E,Gbeassor M

    更新日期：2014-09-11 00:00:00

  • Oral hypoglycaemic, antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings (BOPF) grade black tea (Camellia sinensis L.) in rats.

    abstract：UNLABELLED:ETHNOPHARMCOLOGICAL RELEVANCE: Sri Lankan traditional practitioners recommend the consumption of black tea infusion (BTI) made from Camellia sinensis L. plant for regulation of glycaemia. However, they do not specify the grade of tea and their origin (i.e., agroclimatic elevation) and as such many prediabeti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.02.035

    authors： Abeywickrama KR,Ratnasooriya WD,Amarakoon AM

    更新日期：2011-05-17 00:00:00

  • Chrysoeriol and other polyphenols from Tecoma stans with lipase inhibitory activity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tecoma stans is traditionally used by several ethnical groups in Mexico and Central America to treat diabetes. This species is mentioned in the majority of the ethnopharmacological studies compiled in Mexico focused in medicinal plants used as anti-diabetic treatment. AIM OF THE STUDY:Re...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.03.014

    authors： Ramirez G,Zamilpa A,Zavala M,Perez J,Morales D,Tortoriello J

    更新日期：2016-06-05 00:00:00

  • Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila.

    abstract：AIM OF THE STUDY:Labisia pumila has rejuvenating properties that help women to regain the strength and vigour after giving birth (Burkill, 1935) leading us to speculate that Labisia pumila might also modulate the immune matrix as it is one of the important aspect of healthy state of the living body. MATERIALS AND METH...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.039

    authors： Pandey A,Bani S,Sangwan P,Koul S

    更新日期：2010-10-28 00:00:00

  • Anti-venom potential of butanolic extract of Eclipta prostrata against Malayan pit viper venom.

    abstract：:The butanolic and purified butanolic extracts (PBEs) of Eclipta prostrata were evaluated for their anti-venom potential. Inhibition of lethal, hemorrhagic, proteolytic, and phospholipase A2 activities of Calloselasma rhodostoma (Malayan pit viper (MPV)) venom by these extracts were determined. Demethylwedelolactone wa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.10.014

    authors： Pithayanukul P,Laovachirasuwan S,Bavovada R,Pakmanee N,Suttisri R

    更新日期：2004-02-01 00:00:00

  • A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: a phase IV clinical report.

    abstract：AIM OF THE STUDY:We sought to determine the efficacy as antioxidant and safety profile of the polyherbal formulation in geriatric patients of eastern India. MATERIALS AND METHODS:The study was double-blind, randomized including placebo controlled and was approved by the ethical committee of SSKM hospital. Geriatric pa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2010.12.044

    authors： Banerjee P,Maity S,Das T,Mazumder S

    更新日期：2011-03-24 00:00:00

  • Evaluation of contraceptive activity of methanol extract of Dendrophthoe falcata stem in male albino rats.

    abstract：:The present study was undertaken to evaluate the contraceptive efficacy of methanol extract of Dendrophthoe falcata Ettingsh (family-Loranthaceae), stem in male albino rats as reported in folk remedies. Adult proven fertile male rats were gavaged methanol extract of D. falcata stem at 50, 100 and 200mg/rat/day for 60 ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.02.022

    authors： Gupta RS,Kachhawa JB

    更新日期：2007-05-30 00:00:00

  • Ethnopharmacological importance of medicinal flora from the district of Vehari, Punjab province, Pakistan.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnopharmacological studies are important for the discovery of new drugs from reported indigenous flora. The current study was aimed to document medicinal flora and its therapeutic actions along with the relative importance in local health care system of the district of Vehari, Punjab pr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.02.048

    authors： Ahmed N,Mahmood A,Mahmood A,Sadeghi Z,Farman M

    更新日期：2015-06-20 00:00:00

  • Ovicidal and larvicidal activity of crude extracts of Maesa lanceolata and Plectranthus punctatus against Haemonchus contortus.

    abstract：:The widespread development of anthelmintic resistance and high cost of the conventional anthelmintic drugs, has limited the control of gastrointestinal nematode parasites of sheep and goats and hence led to evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in vitro ovicida...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.014

    authors： Tadesse D,Eguale T,Giday M,Mussa A

    更新日期：2009-03-18 00:00:00

  • Wenshen Xiaozheng Tang induces apoptosis and inhibits migration of ectopic endometriotic stromal cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Wenshen Xiaozheng Tang (WXT), a traditional Chinese medicine prescription, exerted a good therapeutic effect on endometriosis. However, the underlying mechanism is unclear. In the present study, we sought to evaluate the effect of WXT on the proliferation and migration of ectopic endometr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.07.019

    authors： Zhang Z,Cheng X,Gui T,Tao J,Huang M,Zhu L,Luo M,Cao P,Wan G

    更新日期：2016-12-24 00:00:00

  • Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.028

    authors： Ebiloma GU,Igoli JO,Katsoulis E,Donachie AM,Eze A,Gray AI,de Koning HP

    更新日期：2017-04-18 00:00:00

  • A review of medicinal plants showing anticonvulsant activity.

    abstract：:The term epilepsy is collectively designated for a group of chronic central nervous system disorders characterized by spontaneous occurrence of seizures generally associated with the loss of consciousness and body movements (convulsions). The disease has its origin from an early age. Anticonvulsant drugs are used to c...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(88)90226-7

    authors： Chauhan AK,Dobhal MP,Joshi BC

    更新日期：1988-01-01 00:00:00

  • Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qingxue jiedu Formulation (QF) is composed of two classic prescriptions which have been clinically used for more than 5 centuries and appropriately modified through basic theory of traditional Chinese medicine for treating various skin inflammation such as atopic dermatitis (AD), acute de...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113773

    authors： Xiong X,Huang C,Wang F,Dong J,Zhang D,Jiang J,Feng Y,Wu B,Xie T,Cheng L

    更新日期：2020-12-31 00:00:00

  • Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual la...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.12.017

    authors： Singh D,Müller CP,Murugaiyah V,Hamid SBS,Vicknasingam BK,Avery B,Chear NJY,Mansor SM

    更新日期：2018-03-25 00:00:00

  • Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.

    abstract：:Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.2.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America. The degree of inhibition was determined by measuring the increase ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00119-6

    authors： Owen PL,Johns T

    更新日期：1999-02-01 00:00:00

  • Phytoestrogenic effect of Inula racemosa Hook f - A cardioprotective root drug in traditional medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Roots of Inula racemosa are used as a cardio protective in Ayurveda in India, being prescribed as a medicine for precordial chest pain, cough and dyspnoea, both singly and as a poly herbal. AIM:Evaluation of Phytoestrogenic activity of the root extracts of Inula racemosa and compounds is...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.001

    authors： Kalachaveedu M,Raghavan D,Telapolu S,Kuruvilla S,Kedike B

    更新日期：2018-01-10 00:00:00

  • Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.

    abstract：:The effects of 17 flavonoids, isolated from two flavonoid-rich Scutellaria species (Scutellaria baicalensis Georgi and Scutellaria rivularis Wall) used in traditional Chinese medicine, on HL-60 cells were assessed by WST-8. Ten of the flavonoids inhibited the proliferation of HL-60, as shown by IC50 values used as ind...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.11.014

    authors： Sonoda M,Nishiyama T,Matsukawa Y,Moriyasu M

    更新日期：2004-03-01 00:00:00

  • Antinociceptive and hypnotic properties of Celastrus orbiculatus.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Celastrus orbiculatus, a woody vine of the Celastraceae family, has been widely used as a traditional medicine for the treatment of many diseases, including rheumatoid arthritis and odontalgia. In this study, we assessed the sedative and antinociceptive activities of the methanolic extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.052

    authors： Park HJ,Cha DS,Jeon H

    更新日期：2011-10-11 00:00:00

  • Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits.

    abstract：:Myrtus communis L. (Myrtaceae) leaves as well as the volatile oil (Myrtii Oleum; MO) obtained from the leaves are used to lower the blood glucose level in type-2 diabetic patients in Turkish folk medicine. However, little attention has been paid to the therapeutic use of this plant. The present study was designed to i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.03.049

    authors： Sepici A,Gürbüz I,Cevik C,Yesilada E

    更新日期：2004-08-01 00:00:00

  • HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana.

    abstract：AIM OF THE STUDY:Around the world, Tilia species have been used in traditional medicine for their properties as tranquilizer. Furthermore, Mexican species of Tilia have been grouped as Tilia americana var. mexicana, but their specific content in flavonoids is poorly described. In this study, inflorescences of Mexican T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.09.044

    authors： Aguirre-Hernández E,González-Trujano ME,Martínez AL,Moreno J,Kite G,Terrazas T,Soto-Hernández M

    更新日期：2010-01-08 00:00:00

  • Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae.

    abstract：:The effects of Cordyceps cicadae extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that aqueous methanol (50%) extracts of C. cicadae ascocarps portion (CC-1-2) enhanced HMNC proliferation activated with phytohemagglutinin (PHA) wit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00212-x

    authors： Weng SC,Chou CJ,Lin LC,Tsai WJ,Kuo YC

    更新日期：2002-11-01 00:00:00

  • Investigation of some Hypericum species native to Southern of Brazil for antiviral activity.

    abstract：:Three plant species, Hypericum connatum, Hypericum caprifoliatum, Hypericum polyanthemum (Guttiferae), growing in Southern of Brazil were chemically investigated and tested for their antiviral activity against feline immunodeficiency virus (FIV). The chemical analysis revealed the presence of polyphenolic compounds su...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00314-2

    authors： Schmitt AC,Ravazzolo AP,von Poser GL

    更新日期：2001-10-01 00:00:00

  • Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.

    abstract：AIM:Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.02.005

    authors： Cao H,Chen X,Sun H,Sakurai T,Zhou J,Sun W,Lv H,Wang X

    更新日期：2010-04-21 00:00:00

  • The traditional uses, phytochemistry, and pharmacology of Stemona species: A review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants of genus Stemona (Stemonaceae) have been long used locally and traditionally in many South and East Asian counties to relieve cough, dispel phlegm, prevent asthma, control pests, diminish inflammation, decrease pain, and treat some cutaneous diseases. AIM OF STUDY:This review prov...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113112

    authors： Liu Y,Shen Y,Teng L,Yang L,Cao K,Fu Q,Zhang J

    更新日期：2021-01-30 00:00:00

  • Labisia pumila var. alata reduces bacterial load by inducing uroepithelial cell apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Labisia pumila var. alata (LPva) is a traditional medicinal herb used by Malaysian women to treat many ailments of the genitourinary tract. Its phytoestrogenic properties suggest potential to prevent recurrent urinary tract infection (UTI) in women post menopause. The aim of this study wa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.018

    authors： Fazliana M,Ramos NL,Lüthje P,Sekikubo M,Holm A,Wan Nazaimoon WM,Brauner A

    更新日期：2011-06-14 00:00:00

  • Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are st...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.08.032

    authors： Shin SS,Yoon M

    更新日期：2018-01-10 00:00:00

  • Preliminary phytochemical, pharmacological and antibacterial studies of the alkaloidal extracts of the leaves of Synclisia scabrida Miers.

    abstract：:Preliminary phytochemical investigation of the leaves of Synclisia scabrida indicated the presence of two alkaloids in the water extracts and five alkaloids in the ethanol extracts. The alkaloidal fraction obtained from the cold ethanol extract furnished on column-chromatography, a homogeneous amorphous solid which ha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90029-2

    authors： Sokomba E,Wambebe C,Chowdhury BK,Iriah J,Ogbeide ON,Orkor D

    更新日期：1986-11-01 00:00:00