Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae.

Abstract:

:The effects of Cordyceps cicadae extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that aqueous methanol (50%) extracts of C. cicadae ascocarps portion (CC-1-2) enhanced HMNC proliferation activated with phytohemagglutinin (PHA) with an EC(50) of 13.8+/-4.6 micro g/ml. By contrast, the methanol (100%) extracts of C. cicadae insect-body portion (CC-2-1) suppressed HMNC proliferation stimulated by PHA with an IC(50) of 32.5+/-5.2 micro g/ml. Cell viability test indicated that inhibitory effects of CC-2-1 on HMNC proliferation were not through direct cytotoxicity. The action mechanisms of CC-1-2 and CC-2-1 may involve the regulation of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in HMNC. Since CC-2-1 suppressed IL-2 and IFN-gamma production in HMNC induced with PHA. The CC-1-2 enhanced IL-2 and IFN-gamma production of HMNC stimulated with PHA in a concentration dependent manner. Therefore, the results demonstrated that C. cicadae contained growth modulators for HMNC.

journal_name

J Ethnopharmacol

authors

Weng SC,Chou CJ,Lin LC,Tsai WJ,Kuo YC

doi

10.1016/s0378-8741(02)00212-x

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

79-85

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S037887410200212X

journal_volume

83

pub_type

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