Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Hancornia speciosa Gomes are traditionally used to treat diabetes in Brazil. The aim of the study is to evaluate the potential anti-diabetic effect of Hancornia speciosa extract and derived fractions. MATERIALS AND METHODS:The ethanolic extract from Hancornia speciosa leaves and chromatographic fractions thereof were evaluated on α-glucosidase assay, on hyperglycemic effect and glucose uptake. The chemical composition of the extract and its most active fraction was investigated by ESI-LC-MS. RESULTS:The ethanolic extract and derived fractions inhibited α-glucosidase in vitro. However, only the crude extract and the dichloromethane fraction inhibited the hyperglycemic effect induced by starch or glucose. Both the extract and dichloromethane fraction were also able to increase glucose uptake in adipocytes. Bornesitol, quinic acid, and chorogenic acid were identified in the extract, along with flavonoid glycosides, whereas the dichloromethane fraction is majorly composed by esters of lupeol and/or α/β-amirin. CONCLUSIONS:Hancornia speciosa has a potential anti-diabetic effect through a mechanism dependent on inhibition of α-glucosidase and increase on glucose uptake. These results give support to the use on traditional medicine of this medicinal plant.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Pereira AC,Pereira AB,Moreira CC,Botion LM,Lemos VS,Braga FC,Cortes SFdoi
10.1016/j.jep.2014.11.050subject
Has Abstractpub_date
2015-02-23 00:00:00pages
30-5eissn
0378-8741issn
1872-7573pii
S0378-8741(14)00870-8journal_volume
161pub_type
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