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Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.

Abstract：

:Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lee HG,Yu KA,Oh WK,Baeg TW,Oh HC,Ahn JS,Jang WC,Kim JW,Lim JS,Choe YK,Yoon DY

doi

10.1016/j.jep.2005.01.054

keywords:

subject

Has Abstract

pub_date

2005-04-26 00:00:00

pages

339-43

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00129-7

journal_volume

98

pub_type

杂志文章

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