Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:Increasing research on traditional herbal medicines and their phytoconstituents has recognized their usefulness in complementary as adjuvant to chemotherapy in various types of cancers. The oleo-gum resin of Boswellia serrata tree is one such folk medicine, which has been traditionally used for religious, cosmetic as well as medical purposes since ages. The oleo-gum resin of the plant has been used in traditional medicine to treat variety of conditions including inflammatory diseases like arthritis, asthma, chronic pain, bowel conditions and many other diseases. This review presents an overview of scientific studies on cytotoxic and antitumor properties of B. serrata and its constituents. MATERIALS AND METHODS:Literature search was carried out for activities of B. serrata and various isolated boswellic acids such as β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid reported in various cancer types in vitro as well as in vivo. RESULTS:The triterpenoidal fraction of B. serrata (containing boswellic acids) is responsible for the cytotoxic and antitumor properties. Among the screened compounds, 3-O-acetyl-11-keto-β-boswellic acid has been found to be most promising cytotoxic molecule. The cytotoxic and antitumor effects are mainly due to induction of apoptosis through caspase activation, increased Bax expression, NF-κB down regulation and induction of poly (ADP)-ribose polymerase (PARP) cleavage. CONCLUSIONS:Boswellic acids appear to be promising candidates for anticancer drug development in future. However, further in vivo studies are needed. Studies in combination with clinically used anticancer drugs and QSAR studies on individual boswellic acid also need to be carried out.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Khan MA,Ali R,Parveen R,Najmi AK,Ahmad Sdoi
10.1016/j.jep.2016.06.053subject
Has Abstractpub_date
2016-09-15 00:00:00pages
315-323eissn
0378-8741issn
1872-7573pii
S0378-8741(16)30413-5journal_volume
191pub_type
杂志文章,评审abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are st...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.08.032
更新日期：2018-01-10 00:00:00
abstract：:Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal propert...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(98)00154-8
更新日期：1999-04-01 00:00:00
abstract：:In this study, the effect of regular khat chewing on serum glucose and C-peptide levels were investigated in both healthy male individuals and type 2 diabetic patients. The results presented show the levels of glucose and C-peptide of healthy individuals to be non-significantly different between khat and non-khat chew...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00035-7
更新日期：2003-05-01 00:00:00
abstract：AIM OF THE STUDY:Dangnyohwan (DNH) has been used for treatment of diabetes mellitus. However, the exact cellular and molecular mechanisms underlying the beneficial effects of DNH are not well understood. Therefore, we investigated how DNH improves hyperglycemia and insulin resistance in obese-type diabetes model. METH...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.10.040
更新日期：2008-02-12 00:00:00
abstract：:This study sought to examine the antihypertensive mechanism of garlic in two-kidney-one-clip (2K1C) hypertensive rat. In this study, the effect of garlic on serum and tissue including: aorta, heart, kidney, lung as well as circulatory (serum) ACE activity in 2K1C rats were examined. Four groups of rats were selected: ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00080-1
更新日期：2003-06-01 00:00:00
abstract：:Extracts from Helichrysum aureonitens are used topically by the indigenous people of South Africa against infections. The antimicrobial activity-guided fractionation by bioautography of the acetone extract from the aerial parts of H. aureonitens led to the isolation of 3,5,7-trihydroxyflavone (galangin). Evaluation of...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00065-2
更新日期：1997-08-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Bauhinia forficata (BF) has been traditionally used as tea in folk medicine of Brazil for treatment of Diabetes mellitus (DM). AIM OF THE STUDY:To evaluate the effects of BF leaf tea on markers of oxidative damage and antioxidant levels in an experimental model of hyperglycemia in human ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.03.070
更新日期：2013-06-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Momordica charantia L. (Cucurbitaceae) fruits have been used traditionally for centuries, especially for treating diabetes and associated complications. AIM OF THE STUDY:The present study was performed to evaluate neuroprotective effect of lyophilized M. charantia fruit juice against glo...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.10.061
更新日期：2011-01-27 00:00:00
abstract：:The taste and smell of the environment are important to humans in everyday life and are of particular relevance for the selection of medicinal versus non-medicinal plant species. In a 16-months study with the Popoluca of southern Veracruz (Mexico), we focused on the indigenous selection criteria for medicinal plants. ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(02)00078-8
更新日期：2002-08-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ligusticum chuanxiong Hort. (Umbelliferae), a traditional Chinese medicinal herb, is often prescribed together with nitric oxide donors for treating coronary heart diseases such as angina in China; however, studies concerning their pharmacological interaction are scarce. AIM OF THE STUDY...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.01.002
更新日期：2009-03-18 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Most cardiovascular diseases ultimately result in heart failure, an intractable problem in modern medicine. Yangxinshi tablet (YXS) is a Chinese medicine formula that is used clinically to treat coronary heart disease. However, the active compounds, potential targets, and pharmacological ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2019.112227
更新日期：2020-01-10 00:00:00
abstract：OBJECTIVE:To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice. MATERIALS AND METHODS:The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.11.023
更新日期：2009-02-25 00:00:00
abstract：:Hemidesmus indicus has been shown to possess significant activity against immunotoxicity and other pharmacological and physiological disorders. In this communication, we have shown the modulating effect of H. indicus on cumene hydroperoxide-mediated cutaneous oxidative stress and tumor promotion response in murine ski...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(02)00360-4
更新日期：2003-03-01 00:00:00
abstract：AIM OF THE STUDY:The aim of this paper is to compare the changes in the utilization of species from various hemeroby categories (indicating the degree of sensitivity of the plant to human impact) using historical data concerning the years 1888-1994. MATERIALS AND METHODS:The authors digitised 8808 handwritten reports,...
journal_title：Journal of ethnopharmacology
pub_type： 历史文章,杂志文章
doi：10.1016/j.jep.2011.02.030
更新日期：2011-05-17 00:00:00
abstract：:A herbal tea (called an abafado in Brazil) prepared from the dried leaves of lemongrass was administered to healthy volunteers. Following a single dose or 2 weeks of daily oral administration, the abafado produced no changes in serum glucose, urea, creatinine, cholesterol, triglycerides, lipids, total bilirubin, indir...
journal_title：Journal of ethnopharmacology
pub_type： 临床试验,杂志文章
doi：10.1016/0378-8741(86)90074-7
更新日期：1986-07-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb.(PM), (known as Heshouwu () in China) is one of the most important and well mentioned Chinese medicinal herbs in the literature for its use in blackening hair, nourishing liver and kidney, anti-aging, anti-hyperlipidemia, antioxidant, anti-inflammatory, antican...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2021.113864
更新日期：2021-01-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:This paper provides significant ethnopharmacological information on plants used to treat cardiovascular diseases in Navarra, Spain. MATERIAL AND METHODS:Information was collected using semi-structured ethnobotanical interviews with 667 informants (mean age 72; 55.47% women, 44.53% men) i...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.09.047
更新日期：2014-11-18 00:00:00
abstract：AIM OF THE STUDY:In recent years the use of medicinal plants has been growing worldwide and this is particularly true in Lebanon. In the present investigation we report the inhibitory activity against digestive enzymes related to diabetes and angiotensin converting enzyme (ACE) of extracts of nine plant species collect...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.06.003
更新日期：2008-09-02 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:To evaluate the hepatoprotective effect of the root and rhizome of Rhubarb (Rhei Radix et Rhizoma) against α-naphthylisothiocyanate (ANIT)-induced liver injury using metabolic profile of bile acids (BAs) along with biochemical parameters and histological alterations. MATERIALS AND METHOD...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.09.049
更新日期：2012-12-18 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(98)00126-3
更新日期：1999-11-30 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.03.005
更新日期：2018-06-12 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Across Africa, Peul community typically rely on plant-based veterinary knowledge to manage common livestock health problems. Unfortunately, their nomadic life-style being affected by conflicts, land tenure constraints, and drought, they have been shifting to a sedentary life. The process ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113107
更新日期：2020-10-28 00:00:00
abstract：:Propolis collected from a cerrado area in Minas Gerais State, Brazil, was subjected to chromatography on silica gel column and to partition between immiscible solvents. Propolis aqueous-ethanolic extract and fractions obtained were tested for inhibitory activity against periodontitis-causing bacteria. All of the assay...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(02)00003-x
更新日期：2002-04-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cancer is a major health problem worldwide. Drugs' side effects and high cost of treatment remain the main limitations of conventional therapy. Nowadays, developing new therapeutic strategies is necessary. Therefore, medicinal plants can be used to promote novel, safe, and potent anticanc...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2020.113435
更新日期：2021-02-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Chiranthodendron pentadactylon Larreat is frequently used in Mexican traditional medicine as well as in Guatemalan for several medicinal purposes, including their use in the control of diarrhea. AIM OF THE STUDY:This work was undertaken to obtain additional information that support the t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.07.039
更新日期：2012-09-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebe...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.07.017
更新日期：2017-09-14 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(99)00011-2
更新日期：1999-11-01 00:00:00
abstract：:Products of certain plants given to mothers after child birth or to invalids were studied for immunostimulant activity using the macrophage migration index (MMI) as a parameter of macrophage activation and cell-mediated immunity and haemagglutinating antibody (HA) titres and plaque-forming cell (PFC) counts as paramet...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(99)00181-6
更新日期：2000-07-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ginseng (Panax ginseng Meyer) is a very well-known traditional herbal medicine that has long been used to enhance the body's immunity. Because it is a type of ginseng, it is believed that wild simulated ginseng (WSG) also has immune-enhancing activity. However, study on the immune-enhanci...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113218
更新日期：2020-12-05 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY:Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemica...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.08.033
更新日期：2013-10-28 00:00:00
