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Screening of seven selected Rwandan medicinal plants for antimicrobial and antiviral activities.

Abstract：

:Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal properties against several enveloped viruses including herpes simplex, measles, Semliki forest, and vesicular stomatitis viruses. Four plants were diversely active against gram-positive bacteria, two of these showing bactericidal effect against the acid-fast Mycobacterium fortuitum. None of the selected plants was active against gram-negative bacteria or the yeast Candida albicans. From a bioassay-guided fractionation procedure using herpes simplex virus type I as the target model, a virucidal mixture, the maesasaponin mixture A, was isolated from the MeOH extract of Maesa lanceolata. The maesasaponin mixture A exhibited a virucidal activity against herpes simplex types 1 and 2, and vesicular stomatitis viruses.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Sindambiwe JB,Calomme M,Cos P,Totté J,Pieters L,Vlietinck A,Vanden Berghe D

doi

10.1016/s0378-8741(98)00154-8

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

71-7

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874198001548

journal_volume

65

pub_type

杂志文章

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