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Antimutagenic potential of homoisoflavonoids from Muscari racemosum.

Abstract：

:The potential antimutagenic effect of the plant extract of Muscari racemosum bulbs, rich on 3-benzylidene-4-chromanones, was evaluated on three genetic model organisms. The mixture of three homoisoflavonoids was applied together with diagnostic mutagens in the Ames assay on four bacterial strains Salmonella typhimurium TA97, TA98, TA100, TA102, in the toxicity and mutagenicity/antimutagenicity assay on the yeast strain Saccharomyces cerevisiae D7, and in the simultaneous phytotoxicity and clastogenicity/anticlastogenicity assay on Vicia sativa (L.). The extract exerted antimutagenic and anticlastogenic effects due to the presence of homoisoflavonoids, which may be included in the group of natural antimutagens. This genotoxicological study suggests that homoisoflavonoids from M. racemosum (L.) owing to antimutagenic and anticlastogenic properties are of great pharmacological importance, and might be beneficial for prevention of cancer.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Miadoková E,Masterová I,Vlcková V,Dúhová V,Tóth J

doi

10.1016/s0378-8741(02)00135-6

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

381-6

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378874102001356

journal_volume

81

pub_type

杂志文章

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