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Anti-inflammatory effect of a methanolic extract of leaves of Dregea volubilis.

Abstract：

AIM OF STUDY:The aim of this study was to establish the anti-inflammatory activity of the methanolic extract of Dregea volubilis leaves (MEDV) with its fractions and to delineate the possible mechanism of action for MEDV. MATERIALS AND METHODS:The anti-inflammatory activities of MEDV along with its petroleum ether and chloroform fractions were evaluated in a carrageenan induced model of acute inflammation. The effect of MEDV on lipopolysaccharide induced production of nitric oxide (NO) in macrophages was also studied. RESULTS:MEDV (100, 200 and 400 mg/kg body weight) significantly reduced carrageenan induced paw edema; chloroform fraction was most potent (66%, p<0.001). MEDV was non-toxic up to 125 μg/ml in mouse peritoneal macrophages wherein it (0-100 μg/ml) reduced lipopolysaccharide induced NO production. CONCLUSION:MEDV possesses significant anti-inflammatory activity. Chloroform fraction of MEDV showed best anti-inflammatory activity.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Hossain E,Sarkar D,Maiti A,Chatterjee M,Mandal SC,Gupta JK

doi

10.1016/j.jep.2010.08.043

subject

Has Abstract

pub_date

2010-11-11 00:00:00

pages

525-8

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00604-5

journal_volume

132

pub_type

杂志文章

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