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Cardiovascular responses in the normotensive rat produced by intravenous injection of gambirine isolated from Uncaria callophylla B1. ex Korth.

Abstract：

:Among several alkaloids, including dimeric indoles, isolated from Uncaria callophylla, gambirine which is an alkaloid unique to this plant, has been found to be another hypotensive principle from the plant. Intravenous injections of gambirine in the dose range of 0.2 to 10.0 mg/kg caused a dose-related fall in both systolic and diastolic blood pressures as well as heart rate. At all doses gambirine showed a prompt onset of action and at the higher doses (5.0-10 mg/kg), marked persistence of hypotension accompanied by severe bradycardia were observed. In addition, higher doses of gambirine produced a more marked decrease in diastolic than systolic pressure while at lower doses both decreased equally. It is suggested that the hypotensive effect of gambirine may be peripheral in origin and is associated, at least in part, with a cardiac action.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Mok JS,Chang P,Lee KH,Kam TS,Goh SH

doi

10.1016/0378-8741(92)90047-u

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

219-23

issue

3

eissn

0378-8741

issn

1872-7573

pii

0378-8741(92)90047-U

journal_volume

36

pub_type

杂志文章

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