Abstract：
AIM OF THE STUDY:Mitragyna speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to hard work. However there is no scientific information about the effect of mitragynine on the cognitive performances. This study is designed to examine the working memory effects of mitragynine which is extracted from Mitragyna speciosa mature leaves. MATERIALS AND METHODS:The cognitive effect was studied using object location task and the motor activity in open-field test. Mitragynine 5, 10 and 15 mg/kg and were administered by intraperitoneal (IP) for 28 consecutive days and evaluated on day 28 after the last dose treatment. Scopolamine was used as the control positive drug. RESULTS:In this study there is prominent effects on horizontal locomotor activity was observed. Mitragynine significantly reduced locomotor activity in open-field test compared with vehicle. In object location task mitragynine (5, 10 and 15 mg/kg) did not showed any significances discrimination between the object that had changed position than the object that had remain in a constant position. CONCLUSION:Our results suggest that chronic administration of mitragynine can altered the cognitive behavioral function in mice.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Apryani E,Hidayat MT,Moklas MA,Fakurazi S,Idayu NFdoi
10.1016/j.jep.2010.03.036subject
Has Abstractpub_date
2010-06-16 00:00:00pages
357-60issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(10)00211-4journal_volume
129pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2012-03-27 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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abstract：:The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Da Chuanxiong Formula (DCXF) is one of the famous herb pairs that contains dried rhizomes of Ligusticum chuanxiong Hort. and Gastrodia elata Bl. in the mass ratio of 4:1. This classic representative traditional Chinese medicine has been widely used to treat brain diseases like headache an...
journal_title：Journal of ethnopharmacology
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abstract：AIM OF THE STUDY:Characterization and comparative analysis of the main VOCs (volatile organic compounds) present in the smoke of 11 experimentally combusted plant species used as incense in Shaxi, Southwest China. Substances which may be responsible for the pleasant smell of the smokes as well as substances with a pote...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.08.078
更新日期：2011-10-31 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 历史文章,杂志文章
doi：10.1016/j.jep.2006.04.008
更新日期：2006-11-03 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.07.038
更新日期：2013-10-28 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.01.013
更新日期：2014-03-28 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.02.025
更新日期：2014-04-11 00:00:00
abstract：:The present study evaluated the chemical composition and the antimicrobial activity of the extracts and fractions of Mikania laevigata and Mikania glomerata on growth and cell adherence of mutans streptococci. Ethanolic extract, hexane and ethyl acetate fractions of Mikania laevigata and Mikania glomerata were chemica...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2018-04-24 00:00:00
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pub_type： 杂志文章
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更新日期：1982-09-01 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2014-12-02 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea). MATERIALS AND METHODS:Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Q...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2014-04-11 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Herb-drug interactions are of great concern in health practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all over the world. Curcumin is clinically used due to its acceptable safety profile and therapeutic efficacy. AIM OF THE STUDY:Current paper aim...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2017-09-14 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Trillium tschonoskii rhizome (TTR), a medicinal herb, has been traditionally used to treat traumatic brain injury and headache in China. Although the potential neuroprotective efficacy of TTR has gained increasing interest, the pharmacological mechanism remains unclear. Steroid saponins a...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.01.006
更新日期：2018-04-06 00:00:00
