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Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.

Abstract：

:The effects of 17 flavonoids, isolated from two flavonoid-rich Scutellaria species (Scutellaria baicalensis Georgi and Scutellaria rivularis Wall) used in traditional Chinese medicine, on HL-60 cells were assessed by WST-8. Ten of the flavonoids inhibited the proliferation of HL-60, as shown by IC50 values used as indexes of the inhibition. 2',3',5,7-tetrahydroxy flavone (IC50=9.5 microM), apigenin (15.0 microM), viscidulin III (17.4 microM), wogonin (17.4 microM) and luteolin (18.4 microM) were more effective than baicalein (23.0 microM) which reportedly inhibits the proliferation of some cancer cell lines. Others were less effective, and oroxylin A stimulated the proliferation. Scutellaria rivularis, used for the treatment of tumors in the clinic, contained flavonoids that were more inhibitive than those in Scutellaria baicalensis. These results are demonstrative of some reasons for the use of Scutellaria rivularis as a crude antitumor drug.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Sonoda M,Nishiyama T,Matsukawa Y,Moriyasu M

doi

10.1016/j.jep.2003.11.014

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

65-8

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874103004239

journal_volume

91

pub_type

杂志文章

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