当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.

Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.

Abstract：

:The hepatoprotective effects of rubiadin, a major constituent isolated from Rubia cordifolia Linn., were evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Rubiadin at a dose of 50, 100 and 200 mg/kg was administered orally once daily for 14 days. The substantially elevated serum enzymatic activities of serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP) and gamma-glutamyltransferase (gamma-GT) due to carbon tetrachloride treatment were dose dependently restored towards normalization. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were also restored towards normalization. In addition, rubiadin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content in the liver of CCl4 intoxicated rats in a dose dependent manner. Silymarin used as standard reference also exhibited significant hepatoprotective activity on post treatment against carbon tetrachloride induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that rubiadin has a potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Rao GM,Rao CV,Pushpangadan P,Shirwaikar A

doi

10.1016/j.jep.2005.08.073

keywords:

subject

Has Abstract

pub_date

2006-02-20 00:00:00

pages

484-90

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00550-7

journal_volume

103

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Flavonoids from Tilia americana with anxiolytic activity in plus-maze test.

    abstract：:The aerial parts of Tilia americana var. mexicana (Schltdl) Hardin (Tiliaceae) have been widely used in Mexican traditional medicine to relieve sleeplessness, headache, and nervous excitement. The anxiolytic effect of four extracts and several flavonoid fractions from the bracts of Tilia americana subsp.mexicana, var....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.04.019

    authors： Herrera-Ruiz M,Román-Ramos R,Zamilpa A,Tortoriello J,Jiménez-Ferrer JE

    更新日期：2008-07-23 00:00:00

  • Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase.

    abstract：:Oxymatrine is one of the alkaloids extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.) with activities of anti-inflammation, inhibiting immune reaction, antivirus, protecting hepatocytes and antihepatic fibrosis. However, the effect of oxymatrine on acute lung injury (ALI) has not been known yet. In...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.01.026

    authors： Xu GL,Yao L,Rao SY,Gong ZN,Zhang SQ,Yu SQ

    更新日期：2005-04-08 00:00:00

  • Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch.

    abstract：:Water-soluble polysaccharide(Glycyrrhiza polysaccharide, GP) was isolated from Glycyrrhiza uralensis Fisch, with glycosidic units were composed of alpha (1-4) linked D-glucana. We demonstrated that GP significantly induces nitric oxides (NO) production and inducible NO synthase (iNOS) transcription in peritoneal macro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.002

    authors： Cheng A,Wan F,Jin Z,Wang J,Xu X

    更新日期：2008-06-19 00:00:00

  • Matrix degradation inhibitory effect of Schisandra fructus on human articular cartilage and chondrocytes.

    abstract：:The purpose of this study is to assess the protective effects exerted by Schisandra fructus (SF) on hyaluronidase (HAase) and the recombinant human interleukin-1beta (IL-1beta) induced matrix degradation in human articular cartilage and chondrocytes. The effect of SF on the matrix gene expression of immortalized chond...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.12.018

    authors： Choi SI,Park SR,Heo TR

    更新日期：2006-06-30 00:00:00

  • Ethnomedicinal plants of Kathua district, J&K, India.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Natural products, especially those derived from plants, continue to provide new and important leads in the drug discovery process. The first step in drug discovery is to document material traditionally used to treat an ailment. Documentation of such knowledge will lead to its conservation...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.05.028

    authors： Rao PK,Hasan SS,Bhellum BL,Manhas RK

    更新日期：2015-08-02 00:00:00

  • Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model.

    abstract：AIM OF THE STUDY:Asthma is a disease marked by airway inflammation. Petasites japonicus (Pj) is known as an herb for treating asthma, oxidant stress and gastric ulcer in traditional Oriental medicine. In this study, the inhibitory effects of Pj extract on asthmatic responses were examined both in vitro and in vivo. MA...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.10.038

    authors： Lee JS,Yang EJ,Yun CY,Kim DH,Kim IS

    更新日期：2011-01-27 00:00:00

  • Evaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systems.

    abstract：:Paepalantine is an isocoumarin isolated from Paepalanthus vellozioides which showed antimicrobial activity in in vitro experiments. In the present study, paepalantine was tested for possible clastogenic and cytotoxic action. Cultures from different individuals were treated with paepalantine at concentrations of 20, 40...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00061-6

    authors： Tavares DC,Varanda EA,Andrade FD,Vilegas W,Takahashi CS

    更新日期：1999-12-15 00:00:00

  • A review on the elemental contents of Pakistani medicinal plants: Implications for folk medicines.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Substantially, plants produce chemicals such as primary and secondary metabolites, which have significant applications in modern therapy. Indigenous people mostly rely on traditional medicines derived from medicinal plants. These plants have the capacity to absorb a variety of toxic eleme...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2016.05.011

    authors： Aziz MA,Adnan M,Begum S,Azizullah A,Nazir R,Iram S

    更新日期：2016-07-21 00:00:00

  • Traditional detoxification of Jatropha curcas L. seeds.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Jatropha curcas L. is a plant with high cultural significance for quilombola communities of Oriximiná (Pará State, Brazil). Although the plant is highly toxic, its seeds are used in these communities to treat tuberculosis and related diseases and symptoms. AIM OF THE STUDY:This study was...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.111970

    authors： Albino RC,Antoniassi R,de Faria-Machado AF,Ferraris FK,Amendoeira FC,Ramos DF,Silva PEA,Leitão SG,Oliveira DR

    更新日期：2019-09-15 00:00:00

  • Antiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay. AIM OF THE STUDY:To evaluate the in vitro antiplasmodial activity and to identify active compounds from extracts of M....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.021

    authors： Jansen O,Tchinda AT,Loua J,Esters V,Cieckiewicz E,Ledoux A,Toukam PD,Angenot L,Tits M,Balde AM,Frédérich M

    更新日期：2017-05-05 00:00:00

  • The suppressive effects of Saposhnikovia divaricata (Fangfeng) chromone extract on rheumatoid arthritis via inhibition of nuclear factor-κB and mitogen activated proteinkinases activation on collagen-induced arthritis model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Saposhnikovia divaricata (SD), called "Fangfeng" in China, is commonly used in clinical compound prescription for treatment of rheumatoid arthritis (RA), but its actions on RA have not been clarified. The present study aims to determine the anti-inflammatory activity of SD chromone extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.05.023

    authors： Kong X,Liu C,Zhang C,Zhao J,Wang J,Wan H,Zhu H,Zhang P,Chen W,Xiao Y,Lin N

    更新日期：2013-07-30 00:00:00

  • Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3+ regulatory T cells in ovalbumin-sensitized mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Glycyrrhizic acid (GA) is the main bioactive ingredient of licorice (Glycyrrhiza glabra), and has been found to be associated with multiple therapeutic properties. AIM OF THE STUDY:In this study, we investigated immunoregulatory effects of glycyrrhizic acid on anti-asthmatic effects and ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.04.021

    authors： Ma C,Ma Z,Liao XL,Liu J,Fu Q,Ma S

    更新日期：2013-07-30 00:00:00

  • Toxicity studies of medicinal plants used in sub-Saharan Africa.

    abstract：:In sub-Saharan Africa, traditional medicine is widely used in rural and urban areas also. This is essentially due to the prohibitive cost of pharmaceutical-based medicine and the low incomes of a major part of the population. In addition, the efficacies of many of these traditional and plant-based medicines are proven...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2015.06.005

    authors： Boukandou Mounanga M,Mewono L,Aboughe Angone S

    更新日期：2015-11-04 00:00:00

  • Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo.

    abstract：:This study has been carried out in order to evaluate new chemical drugs from plants for biocidal activity before use to avoid noxious effect on human beings and animals or plants and also to prevent the worsing of environment. In fact, many natural products endowed with biological active principles are obtained from p...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.036

    authors： Bagalwa M,Chifundera K

    更新日期：2007-12-03 00:00:00

  • Ethnoveterinary practices of owners of pneumatic-cart pulling camels in Faisalabad City (Pakistan).

    abstract：:The present study was planned to investigate the ethnoveterinary methods practiced by the owners of pneumatic-cart pulling camels in Faisalabad Metropolis (Pakistan). During a 7-year-period (November 1992-November 1999), 200 owners of draught camels working in the city were interviewed. Information concerning the ethn...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.11.008

    authors： Muhammad G,Khan MZ,Hussain MH,Iqbal Z,Iqbal M,Athar M

    更新日期：2005-02-28 00:00:00

  • Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.

    abstract：:Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.2.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America. The degree of inhibition was determined by measuring the increase ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00119-6

    authors： Owen PL,Johns T

    更新日期：1999-02-01 00:00:00

  • Boldine action against the stannous chloride effect.

    abstract：:Peumus boldus extract has been used in popular medicine in the treatment of biliar litiase, hepatic insufficiency and liver congestion. Its effects are associated to the substance boldine that is present in its extract. In the present work, we evaluated the influence of boldine both in: (i) the structural conformation...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00120-8

    authors： Reiniger IW,Ribeiro da Silva C,Felzenszwalb I,de Mattos JC,de Oliveira JF,da Silva Dantas FJ,Bezerra RJ,Caldeira-de-Araújo A,Bernardo-Filho M

    更新日期：1999-12-15 00:00:00

  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ulomoides dermestoides (Fairmaire, 1893) is a cosmopolitan tenebrionid beetle reared by Argentine people who consume them alive as an alternative medicine in the treatment of different illnesses such as asthma, Parkinson's, diabetes, arthritis, HIV and specially cancer. AIM OF THE STUDY:...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.056

    authors： Crespo R,Villaverde ML,Girotti JR,Güerci A,Juárez MP,de Bravo MG

    更新日期：2011-06-14 00:00:00

  • Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK/PI3K/Akt/p38-NF-κB and TGF-β/Smad/Bcl2/Caspase/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There is growing inclination towards developing bioactive molecule-based strategies for the management of allergic airway inflammation associated respiratory diseases. Vitex negundo Linn., also known as Nirgundi, is one such medicinal plant enriched with phytochemicals and used for inflam...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2021.113894

    authors： Tirpude NV,Sharma A,Joshi R,Kumari M,Acharya V

    更新日期：2021-01-28 00:00:00

  • Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats.

    abstract：:In the present study, the anti-inflammatory activity of 70% ethanolic extract of Pongamia pinnata leaves (PLE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of PLE (300, 1000 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin, histam...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00333-6

    authors： Srinivasan K,Muruganandan S,Lal J,Chandra S,Tandan SK,Prakash VR

    更新日期：2001-12-01 00:00:00

  • Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Apocynum venetum Linn. (Apocynaceae family), also called Luobuma, is a shrub which grows widely in the Xinjiang Autonomous Region of China. Its leaves are used in herbal tea for the treatment of hypertension, anxiety and depression. Animal studies have also shown that Apocynum venetum lea...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.035

    authors： Kuo CS,Kwan CY,Gong CL,Tsai MF,Nishibe S,Tatsuzaki J,Leung YM

    更新日期：2011-06-14 00:00:00

  • Promising medicinal plants for bioprospection in a Cerrado area of Chapada do Araripe, Northeastern Brazil.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional medical systems represent an important source of knowledge about the use of biodiversity. Ethnobotanical and ethnopharmacological studies can encourage bioprospecting in the pursuit and selection of promising medicinal plants. This study investigated the diversity of medicinal...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.07.042

    authors： Ribeiro DA,Oliveira LG,Macêdo DG,Menezes IR,Costa JG,Silva MA,Lacerda SR,Souza MM

    更新日期：2014-09-29 00:00:00

  • Amburana cearensis seed extract protects brain mitochondria from oxidative stress and cerebellar cells from excitotoxicity induced by glutamate.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.07.017

    authors： Lima Pereira ÉP,Santos Souza C,Amparo J,Short Ferreira R,Nuñez-Figueredo Y,Gonzaga Fernandez L,Ribeiro PR,Braga-de-Souza S,Amaral da Silva VD,Lima Costa S

    更新日期：2017-09-14 00:00:00

  • Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Astragaloside IV is the primary pure saponin isolated from Astragalus membranaceus, one of the valuable traditional medical herbs. Antifibrotic activities of Astragalus membranaceus have been extensively proved. AIM OF THE STUDY:To investigate the effects of astragaloside IV on hepatic s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.035

    authors： Liu H,Wei W,Sun WY,Li X

    更新日期：2009-04-21 00:00:00

  • Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats.

    abstract：:Ruxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. In this random, blinded study, the anti-arthritic effects of a BC extract were observed and compared to vehicle control in a Lewis rat adjuv...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.03.033

    authors： Fan AY,Lao L,Zhang RX,Zhou AN,Wang LB,Moudgil KD,Lee DY,Ma ZZ,Zhang WY,Berman BM

    更新日期：2005-10-03 00:00:00

  • Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms.

    abstract：:The use of plants as medicine has been referred to since ancient peoples, perhaps as early as Neanderthal man. Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. The study of how people of different culture use plants in particular ways has ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.12.014

    authors： Borges MH,Alves DL,Raslan DS,Piló-Veloso D,Rodrigues VM,Homsi-Brandeburgo MI,de Lima ME

    更新日期：2005-04-08 00:00:00

  • Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes.

    abstract：AIM:To validate plant species for hypoglycaemic activity. MATERIALS AND METHODS:Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: alpha-glucosidase and alpha-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadip...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.052

    authors： Deutschländer MS,van de Venter M,Roux S,Louw J,Lall N

    更新日期：2009-07-30 00:00:00

  • Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Panax ginseng is one of the most well-known medicinal herbs in Korea and China, which has been used for treatment and prevention of cancer, obesity, diabetes, and cardiovascular diseases. Ginsenosides are the major components of P. ginseng, having a wide range of pharmacological activitie...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.08.039

    authors： Han S,Jeong AJ,Yang H,Bin Kang K,Lee H,Yi EH,Kim BH,Cho CH,Chung JW,Sung SH,Ye SK

    更新日期：2016-12-24 00:00:00

  • Ethnoveterinary knowledge and practices at Colares Island, Pará state, eastern Amazon, Brazil.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases. AIM OF THE STUDY:To catalog, analyze an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.09.018

    authors： Ritter RA,Monteiro MV,Monteiro FO,Rodrigues ST,Soares ML,Silva JC,Palha Md,Biondi GF,Rahal SC,Tourinho MM

    更新日期：2012-11-21 00:00:00

  • Allanblackia floribunda Oliv.: An aphrodisiac plant with vasorelaxant properties.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Allanblackia floribunda Oliv. is one of the most commonly used medicinal plant in Cameroon. The stem bark of the plant is traditionally used for its aphrodisiac and antihypertensive properties. AIM OF THE STUDY:To validate the traditional uses of Allanblackia floribunda stem bark ethanol...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.033

    authors： Brusotti G,Papetti A,Serra M,Temporini C,Marini E,Orlandini S,Sanda AK,Watcho P,Kamtchouing P

    更新日期：2016-11-04 00:00:00