当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells.

Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Apocynum venetum Linn. (Apocynaceae family), also called Luobuma, is a shrub which grows widely in the Xinjiang Autonomous Region of China. Its leaves are used in herbal tea for the treatment of hypertension, anxiety and depression. Animal studies have also shown that Apocynum venetum leaf extract (AVLE) also exerts anti-depressant and anti-anxiety activities. The effects of AVLE on neuronal tissues in vitro are not fully understood. MATERIALS AND METHODS:Using the whole-cell voltage-clamp method, we studied the effects of AVLE on ion channels in cultured mouse neuroblastoma N2A cells. RESULTS:AVLE inhibited voltage-gated inward Na(+) current in a reversible and concentration-dependent manner (half-inhibitory concentration was 18 μg/ml and maximum inhibition at 100 μg/ml). AVLE specifically promoted steady-state inactivation of Na(+) channels but did not affect voltage-dependence of activation. The inhibitory effect was not use-dependent and was not affected by 300μM L-NAME, suggesting that NO was not involved in the action of AVLE in neuronal cells. AVLE also had a mild inhibitory effect on voltage-gated K(+) channels, but did not affect ATP-sensitive K(+) channels. CONCLUSIONS:Since voltage-gated Na(+) and K(+) channels are associated with neuronal excitability and therefore affect neurotransmission, the modulation of neuronal ion channels by AVLE may exert neuropharmacological effects. In particular, the inhibition of voltage-gated Na(+) currents by AVLE may in part account for the psychopharmacological effects of this herbal remedy.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kuo CS,Kwan CY,Gong CL,Tsai MF,Nishibe S,Tatsuzaki J,Leung YM

doi

10.1016/j.jep.2011.04.035

subject

Has Abstract

pub_date

2011-06-14 00:00:00

pages

149-55

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00275-3

journal_volume

136

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The antiulcer potentials of most plants still remain largely unexplored, despite their prospects evidenced by their use as ethnomedicine. Entada africana (Mimosaceae) has been widely used in Africa for the treatment of skin infections, wounds, tonic for stomach troubles and against diphth...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.06.012

    authors： Obidike IC,Emeje MO

    更新日期：2011-09-01 00:00:00

  • The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats.

    abstract：AIM OF THE STUDY:The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.016

    authors： Tom EN,Demougeot C,Mtopi OB,Dimo T,Djomeni PD,Bilanda DC,Girard C,Berthelot A

    更新日期：2011-01-27 00:00:00

  • Antibacterial and antibiotic modifying activity evaluation of ruminants' body fat used as zootherapeutics in ethnoveterinary practices in Northeast Brazil.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Northeast Brazilian ethnoveterinary studies associated with the medicinal use of zootherapies have shown that ruminants' body fat such as sheep (Ovis aries), goats (Capra hircus) and cows (Bos taurus) are used in diseases affecting domestic animals. AIM OF THE STUDY:The objective of this...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.12.012

    authors： de Queiroz Dias D,Sales DL,Andrade JC,da Silva ARP,Tintino SR,Oliveira-Tintino CDM,de Araújo Delmondes G,de Oliveira Barbosa M,Coutinho HDM,Ferreira FS,Rocha MFG,Navarro DMDAF,da Rocha SKL,da Costa JGM,Alves RRDN,Almeida WO

    更新日期：2019-04-06 00:00:00

  • Antidiabetic, anti-oxidant and antimicrobial activities of Fadogia ancylantha extracts from Malawi.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Communities in Chilumba, Malawi use herbal tea prepared from Fadogia ancylantha Schweinf (Rubiaceae) leaves for the management of diabetes, hypertension and alleviation of symptoms of gastrointestinal disorders and pneumonia. The objective of the study was to evaluate the in vitro antidia...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.002

    authors： Nyirenda KK,Saka JD,Naidoo D,Maharaj VJ,Muller CJ

    更新日期：2012-08-30 00:00:00

  • Pharmacological evaluation of Alstonia scholaris: anti-tussive, anti-asthmatic and expectorant activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Alstonia scholaris (Apocynaceae) was documented as an effective herb for the treatment of chronic respiratory diseases in "dai" ethnopharmacy historically, and its leaf crude extract, used for releasing tracheitis and cold symptom, was approved to be a commercial formulation by State Food...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.03.029

    authors： Shang JH,Cai XH,Zhao YL,Feng T,Luo XD

    更新日期：2010-06-16 00:00:00

  • Neuropharmacological screening of Diospyros mespiliformis in mice.

    abstract：:The neuropharmacological activities of the aqueous extract of Diospyros mespiliformis stem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00249-0

    authors： Adzu B,Amos S,Muazzam I,Inyang US,Gamaniel KS

    更新日期：2002-11-01 00:00:00

  • Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. Howe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.01.007

    authors： Yu M,Xu X,Jiang N,Wei W,Li F,He L,Luo X

    更新日期：2017-02-23 00:00:00

  • Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Uncaria rhynchophylla (Miq.) Miq. ex Havil., is a plant species used in traditional Chinese medicine to treat cardiovascular and central nervous system diseases. Rhynchophylline (RIN) and isorhynchophylline (IRN), a pair of epimers, are major alkaloids isolated from U. rhynchophylla and e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.07.039

    authors： Wang X,Zheng M,Liu J,Huang Z,Bai Y,Ren Z,Wang Z,Tian Y,Qiao Z,Liu W,Feng F

    更新日期：2017-09-14 00:00:00

  • Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice.

    abstract：AIM OF THE STUDY:Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extrac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.035

    authors： Bras C,Domínguez S,Codón S,Minetti A,Ferrero A

    更新日期：2010-10-28 00:00:00

  • Antidepressant-like effects of Xiaochaihutang in perimenopausal mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Xiaochaihutang (XCHT) is a traditional Chinese medicine prescription for thousand years in China. Our previous researches show that XCHT has antidepressant-like effects in several depression models, but effect and mechanism of XCHT in perimenopausal depression are still vague. AIM OF THE...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112318

    authors： Zhang K,Wang Z,Pan X,Yang J,Wu C

    更新日期：2020-02-10 00:00:00

  • Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:FuFang ZhenZhu TiaoZhi (FTZ) is a hospitalized traditional Chinese medicine herbal formula with documented metabolic benefits. Polycystic ovary syndrome (PCOS) characterized by ovarian dysfunction and insulin resistance represents one of the most common endocrine disorders in close associ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113587

    authors： Xu Y,Tang J,Guo Q,Xu Y,Yan K,Wu L,Xie K,Zhu A,Rong X,Ye D,Guo J

    更新日期：2021-03-25 00:00:00

  • Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.

    abstract：AIM OF THE STUDY:For identification of the active constituents we investigated the anticancer activity of cardenolides from Streptocaulon tomentosum Wight & Arn. (Asclepiadaceae) and from Nerium oleander L. (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin. MATERIAL...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.038

    authors： Rashan LJ,Franke K,Khine MM,Kelter G,Fiebig HH,Neumann J,Wessjohann LA

    更新日期：2011-04-12 00:00:00

  • Bioactivity of certain medicinal latexes used by the Ese'ejas.

    abstract：:Latexes from Croton erythrochilus, Ficus inspidia and Sapium marmieri used traditionally as medicinal by the Ese'ejas were analyzed for bioactivity. The assays run were: the brine shrimp toxicity microplate bioassay, the wheat rootlet growth inhibition and the DNA-methyl green bioassay. The three latexes showed cytoto...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01262-c

    authors： Mongelli E,Desmarchelier C,Giulietti A,Coussio J,Ciccia G

    更新日期：1995-07-28 00:00:00

  • Comparative pharmacokinetics of six coumarins in normal and breast cancer bone-metastatic mice after oral administration of Wenshen Zhuanggu Formula.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Wenshen Zhuanggu Formula (WSZG) is a traditional Chinese medicine (TCM) prescription used in clinics for adjuvant treatment of breast cancer bone metastases in Longhua Hospital in China. WSZG has been reported to decrease the risk of bone metastases and alleviate the severity of bone lesi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.05.031

    authors： Chen W,Li J,Sun Z,Wu C,Ma J,Wang J,Liu S,Han X

    更新日期：2018-10-05 00:00:00

  • [Ethnobotany of Euphorbiaceae of West Africa].

    abstract：:The following ethnobotanical study is a compilation of medicinal Euphorbiaceae in West Africa (Senegal, Gambia, Guinea Bissau, Guinea, Sierra Leone, Liberia, Ivory Coast, Mali, Bourkina Faso, Ghana, Togo, Bénin, Niger, Nigeria), and includes 81 species distributed in 37 genera. It includes a reminder of the genera's p...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90064-4

    authors： Stäuble N

    更新日期：1986-04-01 00:00:00

  • The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury.

    abstract：:This study was undertaken to investigate the protective effects of Phyllanthus emblica Linn. (PE) extract on ethanol induced rat hepatic injury. PE (0.5 and 1 mg/ml) increased cell viability of rat primary cultured hepatocytes being treated with ethanol (96 microl/m) by increasing % MTT and decreasing the release of t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.03.035

    authors： Pramyothin P,Samosorn P,Poungshompoo S,Chaichantipyuth C

    更新日期：2006-10-11 00:00:00

  • Fasciolicidal efficacy of Albizia anthelmintica and Balanites aegyptiaca compared with albendazole.

    abstract：:An attempt was made to evaluate the oral doses of 9 g/kg-body weight of Albizzia anthelmintica Brong. Mimoaseae stem bark water extract and 9 g/kg body weight of B. aegyptiaca (L) Del. (Balanitaceae) fruit mesocarp water extract (traditionally used as an anthelmintic in the Sudan) compared with 20 mg/kg body weight (r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00172-0

    authors： Koko WS,Galal M,Khalid HS

    更新日期：2000-07-01 00:00:00

  • In vitro bioactivity-guided fractionation and characterization of polyphenolic inhibitory fractions from Acacia nilotica (L.) Willd. ex Del.

    abstract：:The present study was undertaken to evaluate antimutagenic and cytotoxic effects of different extracts/fractions of Acacia nilotica prepared by maceration method. The potency order of different extracts was more or less similar in Ames assay as well as in cytotoxic assay. Considering the maximum potential of acetone e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.01.040

    authors： Kaur K,Michael H,Arora S,Härkönen P,Kumar S

    更新日期：2005-07-14 00:00:00

  • Natural products against acute respiratory infections: Strategies and lessons learned.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:A wide variety of traditional herbal remedies have been used throughout history for the treatment of symptoms related to acute respiratory infections (ARIs). AIM OF THE REVIEW:The present work provides a timely overview of natural products affecting the most common pathogens involved in ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112298

    authors： Langeder J,Grienke U,Chen Y,Kirchmair J,Schmidtke M,Rollinger JM

    更新日期：2020-02-10 00:00:00

  • Antifertility studies of the root extract of the Barleria prionitis Linn in male albino rats with special reference to testicular cell population dynamics.

    abstract：:Oral administration of root extract of Barleria prionitis L. to male rats (100 mg/rat per day) for the period of 60 days did not cause body weight loss. The root extract brought about an interference with spermatogenesis. The round spermatids were decreased by 73.6% (P< or =0.001). No significant change was found in t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00150-6

    authors： Gupta RS,Kumar P,Dixit VP,Dobhal MP

    更新日期：2000-05-01 00:00:00

  • Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.047

    authors： Seleteng Kose L,Moteetee A,Van Vuuren S

    更新日期：2015-07-21 00:00:00

  • Antibacterial activities of extracts from Ugandan medicinal plants used for oral care.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants are widely used for treatment of oral/dental diseases in Uganda. AIM OF THE STUDY:To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC). MATERIALS AND METHODS:Pulp ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.06.027

    authors： Ocheng F,Bwanga F,Joloba M,Borg-Karlson AK,Gustafsson A,Obua C

    更新日期：2014-08-08 00:00:00

  • A review of pharmacological and clinical studies on the application of Shenling Baizhu San in treatment of Ulcerative colitis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The prescription of Shenling Baizhu San (SLBZS) was derived from the Song Dynasty "Taiping Huimin Heji Ju Fang", which was a representative prescription for treating spleen asthenic diarrhea. The prescription comprised of 10 herbs for treating weak spleen and stomach. It describes symptom...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112105

    authors： Ma Q,Ouyang Y,Meng F,Noolvi MN,Avvaru SP,More UA,Aminabhavi TM,Du M,Liu H,Zhuang Y,Pang M,Cai T,Cai Y

    更新日期：2019-11-15 00:00:00

  • Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Baizi Yangxin Pills (BZYXP), a popular cinnabar (α-HgS) contained Traditional Chinese Medicines (TCMs) is widely used in clinical trials. However, mercury is one of the most toxic elements. The adverse effects of cinnabar-containing TCMs have been occasionally reported in recent years, le...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112489

    authors： Lu YT,Qi WZ,Wang S,Song XN,Yang DY,Song M,Hang TJ

    更新日期：2020-03-25 00:00:00

  • Toxicity of Hydnora johannis Becca. dried roots and ethanol extract in rats.

    abstract：AIM OF THE STUDY:Hydnora johannis Becca. (Hydnoraceae) commonly is used for the treatment of dysentery, diarrhoea, cholera and swelling tonsillitis in the folk medicine of Sudan and other African countries. This study evaluates the toxicological effects of Hydnora johannis roots on Wistar rats. MATERIALS AND METHODS:R...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.06.044

    authors： Yagi S,Yagi AI,Gadir EH,Henry M,Chapleur Y,Laurain-Mattar D

    更新日期：2011-09-01 00:00:00

  • Effect of glycans of Saccharum officinarum on carbohydrate and lipid metabolism of rats.

    abstract：:A polysaccharide fraction of Saccharum officinarum was tested for its effects on carbohydrate and lipid metabolism in normal rats and those fed a high sugar diet. Feeding with the high sugar diet induced an elevation of serum glucose and significant accumulation of lipid peroxides in the serum and liver. The accumulat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(85)90092-3

    authors： Hikino H,Takahashi M,Konno C,Ishimori A,Kawamura T,Namiki T

    更新日期：1985-11-01 00:00:00

  • Antimicrobial activities of southern Nepalese medicinal plants.

    abstract：:In an ethnopharmacological screening of selected medicinal plants used in Nepal, methanol extracts from 20 plant species were assayed for activity against eleven strains of bacteria and four strains of fungi. Duplicate assays were conducted with and without exposure to ultraviolet (UV)-A radiation to test for light-ac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01335-0

    authors： Taylor RS,Edel F,Manandhar NP,Towers GH

    更新日期：1996-02-01 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.017

    authors： Eddouks M,Ajebli M,Hebi M

    更新日期：2017-02-23 00:00:00

  • Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ficus religiosa (Moraceae) is reported to have numerous therapeutic utility in folk medicine. Among different biological activities on central nervous system, it has been reported to be used in ethnomedical treatment of epilepsy, which led us to further explore its anticonvulsant activity...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.02.042

    authors： Singh D,Goel RK

    更新日期：2009-06-22 00:00:00

  • Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala.

    abstract：:Centaurea phyllocephala Boiss. has been used in folkloric medicine as an antidiabetic agent. Present investigations on various extracts of C. phyllocephala revealed that basal plasma glucose concentration and plasma glucose response to glucose load were either elevated or unchanged by the i.v. administration of these ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(83)90037-5

    authors： Twaij HA,Kery A,Al-Khazraji NK

    更新日期：1983-12-01 00:00:00