当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats.

The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats.

Abstract：

AIM OF THE STUDY:The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba. MATERIALS AND METHODS:Hypertension was obtained in rats by oral administration of 10% D-glucose for 3 weeks. The acute effects of Terminalia superba were studied on blood pressure (BP) and heart rate (HR) after intravenous administration in normotensive rats (NTR) and glucose hypertensive rats (GHR). The antihypertensive effects were studied after oral administration of the extract (50 and 100 mg/kg/day) or nifedipine (10 mg/kg/day) for 3 weeks. At the end of the experiment, BP and HR were measured and reduced glutathione (GSH), malondialdehyde (MDA) and superoxide dismutase (SOD) activity levels were measured in heart, aorta, liver and kidney. RESULTS:Intravenous administration of the aqueous extract of Terminalia superba induced a significant hypotensive response without any change in HR. The hypotensive effect of the extract was unaffected by atropine or propranolol but decreased by reserpine (5 mg/kg) and yohimbine (0.1 mg/kg). In addition, the oral administration of the extract significantly prevented the rise in BP in glucose-hypertensive rats. Finally, the treatment with plant extract significantly blunted the decrease in GSH and the increase in MDA levels associated with hypertension, and significantly prevents the increase in aortic SOD activity. CONCLUSIONS:The present study demonstrates that the aqueous extract of the stem bark of Terminalia superba exhibits hypotensive and anti-hypertensive properties that are, at least in part, related to a withdrawal of sympathetic tone and to an improvement of the antioxidant status, respectively. Overall data validate the use of Terminalia superba as antihypertensive therapy in traditional medicine.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Tom EN,Demougeot C,Mtopi OB,Dimo T,Djomeni PD,Bilanda DC,Girard C,Berthelot A

doi

10.1016/j.jep.2010.11.016

subject

Has Abstract

pub_date

2011-01-27 00:00:00

pages

828-33

issue

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00801-9

journal_volume

133

pub_type

杂志文章

在线工具

The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats.