当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Identification of the toxic constituents in Rhizoma Coptidis.

Identification of the toxic constituents in Rhizoma Coptidis.

Abstract：

AIM OF THE STUDY:Rhizoma Coptidis (Huanglian) is a widely used Traditional Chinese Medicine. However, it causes human as well as animal toxicities. In this study, we aimed to ascertain the toxic constituents in Rhizoma Coptidis. MATERIALS AND METHODS:The acute toxicity of both the total extract and the alkaloid-rich extract of Rhizoma Coptidis were tested in mice. The dose related tissue concentration of the Rhizoma Coptidis alkaloids in mice was determined using high performance liquid chromatography with ultraviolet detection. The influence of phenobarbital sodium [a non-selective hepatic enzyme (P450) inducer] on the acute toxicity of Rhizoma Coptidis as well as the tissue concentration of the alkaloids was investigated. The cytotoxicity of the Rhizoma Coptidis alkaloids was tested in six cell lines using the MTT assay. RESULTS:The median acute oral lethal dose of the total extract of Rhizoma Coptidis was 2.95g/kg in mice. The alkaloid-rich extract was much more toxic than the total extract of Rhizoma Coptidis. Four Rhizoma Coptidis alkaloids were detected in brain, heart, and lung tissues of mice that received the oral total extract of Rhizoma Coptidis. Tissue concentration increased nonlinearly with higher doses. Phenobarbital sodium decreased the tissue concentration of every alkaloid as well as the toxicity of Rhizoma Coptidis. All alkaloids, especially berberine, showed dose and time dependent cytotoxicity. CONCLUSIONS:The toxic constituents of Rhizoma Coptidis were the alkaloids, mainly berberine.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Ma BL,Ma YM,Shi R,Wang TM,Zhang N,Wang CH,Yang Y

doi

10.1016/j.jep.2010.01.047

subject

Has Abstract

pub_date

2010-03-24 00:00:00

pages

357-64

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00078-4

journal_volume

128

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Eugenia brasiliensis leaves extract attenuates visceral and somatic inflammatory pain in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Eugenia brasiliensis Lam. (Myrtaceae) is a Brazilian tree distributed throughout Atlantic rain forest, since Bahia until Santa Catarina state, and is popularly known as "grumixaba, grumixameira, cumbixaba, ibaporoiti, and cereja-brasileira". The bark and leaves of Eugenia brasiliensis are...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.02.026

    authors： Simões RR,Kraus SI,Coelho IS,Dal-Secco D,Siebert DA,Micke GA,Alberton MD,Santos ARS

    更新日期：2018-05-10 00:00:00

  • Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica.

    abstract：:The extractives, crude and pure, of Alepidea amatymbica (AA) and Xylopia aethiopica (XA) were subjected to bioassay-directed phytochemical examination for potential cardiovascular and diuretic activity. All extractives and derivatives (XA/O, AA/1, xylopic acid, AA/3, AA/4, AA/5, AA/6, XA/1, XA/2, XA/3) displayed low t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00285-9

    authors： Somova LI,Shode FO,Moodley K,Govender Y

    更新日期：2001-10-01 00:00:00

  • Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae).

    abstract：AIMS OF THE STUDY:The South American mint genus Minthostachys is of great importance in the Andes as a medicinal, aromatic, culinary and commercial essential oil plant. After decades of taxonomic confusion and virtual indeterminability of specimens, new systematic and taxonomic work has been conducted in recent years. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.05.030

    authors： Schmidt-Lebuhn AN

    更新日期：2008-08-13 00:00:00

  • The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The herbal composition Gyeongshingangjeehwan 18 (GGEx18), composed of Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae), is used as an antiobesity drug in Korean clinics. The constituents of GGEx18 have traditionally been r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.06.034

    authors： Lim J,Lee H,Ahn J,Kim J,Jang J,Park Y,Jeong B,Yang H,Shin SS,Yoon M

    更新日期：2018-10-28 00:00:00

  • Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.

    abstract：:Galangin is one of the active antimicrobial principles of propolis or 'bee glue' and Helichrysum aureonitens, a perennial herb used by South African indigenes to treat infection. The effect of this compound and antibacterial agents with known mechanisms of action upon the cytoplasmic membrane integrity of Staphylococc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.04.014

    authors： Cushnie TP,Lamb AJ

    更新日期：2005-10-03 00:00:00

  • Protective effect of HwangRyunHaeDok-Tang water extract against chronic obstructive pulmonary disease induced by cigarette smoke and lipopolysaccharide in a mouse model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Hwangryunhaedok-tang is an oriental herbal formula treated to cure inflammation and gastric disorders in China, Japan, and Korea. We explored the protective effects of Hwangryunhaedok-tang water extract (HRWE) against airway pathophysiological changes caused by cigarette smoke (CS) and li...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.02.027

    authors： Shin NR,Ko JW,Park SH,Cho YK,Oh SR,Ahn KS,Ryu JM,Kim JC,Seo CS,Shin IS

    更新日期：2017-03-22 00:00:00

  • Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.

    abstract：:The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00258-7

    authors： Feresin GE,Tapia A,Sortino M,Zacchino S,de Arias AR,Inchausti A,Yaluff G,Rodriguez J,Theoduloz C,Schmeda-Hirschmann G

    更新日期：2003-10-01 00:00:00

  • Euphorbia lunulata extract acts on multidrug resistant gastric cancer cells to inhibit cell proliferation, migration and invasion, arrest cell cycle progression, and induce apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The milky sap or the aboveground part of the plant Euphorbia lunulata has long been used by Chinese people to treat noncancerous growths and cancerous ailments but the specific mode of action and the action mechanism remain to be elucidated. AIM OF THE STUDY:To investigate the effects of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.08.014

    authors： Fu Z,Han X,Du J,Han X,Liu W,Shao S,Liu X

    更新日期：2018-02-15 00:00:00

  • Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Senescent leaves of Heliotropium foertherianum Diane & Hilger (Boraginaceae) are traditionally used in the Pacific region to treat Ciguatera Fish Poisoning. This plant contains rosmarinic acid that is known for its multiple biological activities. In the present study, H. foertherianum aqu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.05.045

    authors： Rossi F,Jullian V,Pawlowiez R,Kumar-Roiné S,Haddad M,Darius HT,Gaertner-Mazouni N,Chinain M,Laurent D

    更新日期：2012-08-30 00:00:00

  • Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

    abstract：AIM OF THE STUDY:Rhei Rhizoma, the rhizome of Rheum palmatum L. (RP), is a popular herb in clinical Chinese medicine. RP is abundant in polyphenolic anthraquinones, which have been reported to show various beneficial bioactivities. This study investigated the pharmacokinetics and tissue distribution of anthraquinones f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.08.003

    authors： Shia CS,Tsai SY,Lin JC,Li ML,Ko MH,Chao PD,Huang YC,Hou YC

    更新日期：2011-10-11 00:00:00

  • Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Liuwei Dihuang (LWDH) is a classic prescription that has been used as a traditional medicinal formula for more than 1000 years in China. In clinical, LWDF is used for treating functional decline associated with senile disease and menopausal syndrome. Studies have demonstrated that LWDH co...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112207

    authors： Meng Q,Yu X,Chen Q,Wu X,Kong X,Wang S,Cai D,Cheng P,Li Y,Bian H

    更新日期：2020-01-10 00:00:00

  • Intestinal anti-inflammatory effects of fuzi-ganjiang herb pair against DSS-induced ulcerative colitis in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuzi and ganjiang are widely used as traditional Chinese medicines (TCM) in China, Korea, Japan, and many other southeast Asian countries for treating ulcerative colitis (UC), emesis and heart failure for more than 1800 years. However, the underlying mechanism of fuzi, ganjiang and fuzi-g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112951

    authors： Huang C,Dong J,Jin X,Ma H,Zhang D,Wang F,Cheng L,Feng Y,Xiong X,Jiang J,Hu L,Lei M,Wu B,Zhang G

    更新日期：2020-10-28 00:00:00

  • Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY:To investigate the anti-asthmatic effects of Peucedanum ja...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.006

    authors： Chun JM,Lee AR,Kim HS,Lee AY,Gu GJ,Moon BC,Kwon BI

    更新日期：2018-01-30 00:00:00

  • Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice.

    abstract：AIM OF THE STUDY:Sophora flavescens has been used as an antipyretic and analgesic agent. To assess the possible herb-drug interaction, effects of S. flavescens extracts on hepatic cytochrome P450 (P450, CYP) enzymes were studied. MATERIALS AND METHODS:Effects of the extracts prepared by three different pharmaceutical ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.09.018

    authors： Ueng YF,Chen CC,Tsai CC,Soucek P

    更新日期：2009-12-10 00:00:00

  • Evaluation of extracts of Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii for activity against bacterial isolates from cases of non-gonococcal urethritis.

    abstract：:Whole root preparations of three Nigerian medicinal plants, Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii, used traditionally in combination treatment of sexually transmitted diseases (STD), were extracted by maceration in ethanol, cold and hot water, respectively. The extracts were tested, by agar di...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.12.015

    authors： Okoli AS,Iroegbu CU

    更新日期：2004-05-01 00:00:00

  • Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats.

    abstract：:The leaves of Moringa oleifera Lam (Moringaceae) are used by the Indians in their herbal medicine as a hypocholesterolemic agent in obese patients. The scientific basis for their use in hypercholesterolemia was therefore examined. It was found that administration of the crude leaf extract of Moringa oleifera along wit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00106-3

    authors： Ghasi S,Nwobodo E,Ofili JO

    更新日期：2000-01-01 00:00:00

  • Medicinal plants used for cardiovascular diseases in Navarra and their validation from official sources.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:This paper provides significant ethnopharmacological information on plants used to treat cardiovascular diseases in Navarra, Spain. MATERIAL AND METHODS:Information was collected using semi-structured ethnobotanical interviews with 667 informants (mean age 72; 55.47% women, 44.53% men) i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.047

    authors： Calvo MI,Cavero RY

    更新日期：2014-11-18 00:00:00

  • The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.

    abstract：AIM OF THE STUDY:The objectives of this study were to investigate the adjuvant anti-tumor effects of Antrodia camphorate in human hepatoma cells (C3A and PLC/PRF/5) which are resistance to most anti-tumor agents, elucidate the possible regulation pathways, and measure the tumor growth and survival rate in xenograft-nud...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.05.001

    authors： Chang CY,Huang ZN,Yu HH,Chang LH,Li SL,Chen YP,Lee KY,Chuu JJ

    更新日期：2008-08-13 00:00:00

  • The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus.

    abstract：:This study was undertaken to investigate whether a tea prepared from Syzygium cumini, reported to be used by diabetics in Porto Alegre, Brazil, might have an antihyperglycemic effect in experimental models. Teas prepared from leaves and seeds of S. cumini, in concentrations ranging from 2-64 g/l, were administered, as...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)01532-8

    authors： Teixeira CC,Pinto LP,Kessler FH,Knijnik L,Pinto CP,Gastaldo GJ,Fuchs FD

    更新日期：1997-05-01 00:00:00

  • Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs.

    abstract：:Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90018-9

    authors： Pantoja CV,Chiang LC,Norris BC,Concha JB

    更新日期：1991-03-01 00:00:00

  • Hypoglycemic effect of Tournefortia hirsutissima L., on n-streptozotocin diabetic rats.

    abstract：:The hypoglycemic effect of aqueous and butanolic extracts from Tournefortia hirsutissima (Boraginaceae) was determined on neonatal induced streptozotocin diabetic rats (n-STZ). Oral administration of water extracts at doses of 20 and 80mg/kg, and butanolic extracts (8 and 80mg/kg) significantly lowered the plasma gluc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.02.020

    authors： Andrade-Cetto A,Revilla-Monsalve C,Wiedenfeld H

    更新日期：2007-05-30 00:00:00

  • Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231.

    abstract：AIM OF THE STUDY:Scutellaria barbata is a traditional Chinese medicine for cancer treatments. Pheophorbide-a (Pa), one of the active components isolated from this herbal medicine has been proposed to be a potential natural photosensitizer for photodynamic therapy. The anti-tumor effect of pheophorbide-a based photodyna...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.06.007

    authors： Bui-Xuan NH,Tang PM,Wong CK,Fung KP

    更新日期：2010-08-19 00:00:00

  • Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes.

    abstract：AIM:To validate plant species for hypoglycaemic activity. MATERIALS AND METHODS:Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: alpha-glucosidase and alpha-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadip...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.052

    authors： Deutschländer MS,van de Venter M,Roux S,Louw J,Lall N

    更新日期：2009-07-30 00:00:00

  • Effect of the flavonoid fraction of Lithocarpus polystachyus Rehd. on spontaneously hypertensive and normotensive rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lilhocarpus polystachys Rehd. (Sweet Tea, ST) is a folk herbal medicine that has been traditionally used as a natural remedy for hypertension in China, whose mechanism remains unveiled. Flavonoid fraction is considered as the major active components in ST. This study aimed to provide expe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.06.016

    authors： Hou SZ,Xu SJ,Jiang DX,Chen SX,Wang LL,Huang S,Lai XP

    更新日期：2012-09-28 00:00:00

  • Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The blister beetle, also known as Mylabris cichorii, is not only widely used in clinical applications in Chinese anticancer medicine, but is also one of the main ingredients in a variety of traditional Chinese medicinal preparations with anticancer activity. However, the strong toxicity e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.03.058

    authors： Yu M,Zhao Y

    更新日期：2016-06-20 00:00:00

  • Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala.

    abstract：:Centaurea phyllocephala Boiss. has been used in folkloric medicine as an antidiabetic agent. Present investigations on various extracts of C. phyllocephala revealed that basal plasma glucose concentration and plasma glucose response to glucose load were either elevated or unchanged by the i.v. administration of these ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(83)90037-5

    authors： Twaij HA,Kery A,Al-Khazraji NK

    更新日期：1983-12-01 00:00:00

  • Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.047

    authors： Seleteng Kose L,Moteetee A,Van Vuuren S

    更新日期：2015-07-21 00:00:00

  • Allanblackia floribunda Oliv.: An aphrodisiac plant with vasorelaxant properties.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Allanblackia floribunda Oliv. is one of the most commonly used medicinal plant in Cameroon. The stem bark of the plant is traditionally used for its aphrodisiac and antihypertensive properties. AIM OF THE STUDY:To validate the traditional uses of Allanblackia floribunda stem bark ethanol...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.033

    authors： Brusotti G,Papetti A,Serra M,Temporini C,Marini E,Orlandini S,Sanda AK,Watcho P,Kamtchouing P

    更新日期：2016-11-04 00:00:00

  • Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Xiao-Ban-Xia-Tang (XBXT), a traditional Chinese herbal medicine, has been used in China for more than 2000 years, and proved to be effective on various cases of vomiting in the clinic. OBJECTIVE:To investigate the antiemetic effect of XBXT on cisplatin-induced acute and delayed emesis an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.01.027

    authors： Qian Q,Chen W,Yue W,Yang Z,Liu Z,Qian W

    更新日期：2010-04-21 00:00:00

  • Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch.

    abstract：:Water-soluble polysaccharide(Glycyrrhiza polysaccharide, GP) was isolated from Glycyrrhiza uralensis Fisch, with glycosidic units were composed of alpha (1-4) linked D-glucana. We demonstrated that GP significantly induces nitric oxides (NO) production and inducible NO synthase (iNOS) transcription in peritoneal macro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.002

    authors： Cheng A,Wan F,Jin Z,Wang J,Xu X

    更新日期：2008-06-19 00:00:00