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Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats.

Abstract：

:The effect of the aqueous extract of Retama raetam (RR) on blood glucose levels was investigated in fasting normal and streptozotocin-induced diabetic rats after single and repeated oral administration. The aqueous extract of RR at a dose of 20mg/kg significantly reduced the blood glucose in normal rats 6h after a single oral administration (P<0.005) and two weeks after repeated oral administration (P<0.05). This hypoglycaemic effect is more pronounced in streptozotocin (STZ) diabetic rats (P<0.001). The aqueous extract of RR had no effect on basal plasma insulin levels indicating that the underlying mechanism of RR activity is extra-pancreatic. These findings suggest that the aqueous extract of RR possess significant hypoglycaemic effect in both normal and STZ diabetic rats.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Maghrani M,Lemhadri A,Jouad H,Michel JB,Eddouks M

doi

10.1016/s0378-8741(03)00104-1

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

21-5

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874103001041

journal_volume

87

pub_type

杂志文章

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