Abstract:
:The present study was undertaken to investigate the antinociceptive and anti-inflammatory activities of the leaf and twig extracts of Dorstenia barteri (Moraceae) in mice. Both the leaf and twig extracts of Dorstenia barteri at 50, 100 and 200 mg/kg showed significant (P < 0.05-0.01) antinociceptive activities in chemical-, mechanical- and thermal-induced pain test models. Intraperitoneal administration of the plant extracts at 50, 100 and 200 mg/kg significantly (P < 0.05-0.01) inhibited carrageenin-induced acute inflammation in oedema paw weight, pulmonary oedema and number of pleural leucocytes in a dose-dependent way. The twig extract was found to be more active than the leaf extract in all the experimental models used. The inhibitory effects of the plant extracts were comparable to those of the reference drugs acetylsalicyclic acid (ASA) and phenylbutazone (PBZ) at 100 mg/kg i.p. The significant reduction in acetic acid-induced abdominal contractions, the decrease in oedema paw weight as well as in the number of leucocytes in the pleural cavity exudates, and the significant increase in the reaction time and pain threshold of mice observed in this study suggest that Dorstenia barteri extracts possess both anti-inflammatory and antinociceptive activities. The present study, therefore, lend pharmacological support to the folkloric uses of Dorstenia barteri extracts in the treatment, control and/or management of arthritis, rheumatism, gout, headache and other forms of body pains in some parts of Africa.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Omisore NO,Adewunmi CO,Iwalewa EO,Ngadjui BT,Watchueng J,Abegaz BM,Ojewole JAdoi
10.1016/j.jep.2004.05.022keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
7-12issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(04)00295-8journal_volume
95pub_type
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-21 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of ethnopharmacology
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更新日期:2006-04-21 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-12-03 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2016-04-02 00:00:00
abstract:UNLABELLED:The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases and intermittent fever. Most of the pharmacological investigations of Passiflora edulis have been addressed to its Central Nervous System activities, such as anxiolytic, anticonvulsant an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-01-19 00:00:00