当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Effects of dichloromethane and butanol fractions of Gochnatia polymorpha floccosa in maternal reproductive outcome, embryo-fetal development and DNA integrity in mice.

Effects of dichloromethane and butanol fractions of Gochnatia polymorpha floccosa in maternal reproductive outcome, embryo-fetal development and DNA integrity in mice.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Gochnatia polymorpha ssp. floccosa (Asteraceae) also known as ''Cambará'' is used as medicinal plant in Brazil to treat infections and inflammation. Previous studies showed that its ethanolic extract could be bioprospecting of a new anti-inflammatory phytotherapy for use during pregnancy. This work aimed to evaluate dichloromethane (DCM) and butanolic (BT) fractions from G. polymorpha on embryo-fetal development and DNA integrity in mice. MATERIALS AND METHODS:Female mice were treated with 50 and 20mg/kg of the DCM and BT fractions, respectively, during organogenesis and gestational period. RESULTS AND CONCLUSION:The present study shows that DCM and BT fractions from G. polymorpha possess mutagenic activity but are not teratogenic. Based on the fact that the reproductive indices are similar in control and treated animals, we may infer that the mutagenic effect was in somatic cell, at least in part, because the reabsorption number and reabsorption rates did not change in DCM and BT exposed groups.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Pessatto LR,Auharek SA,Gonçalves CA,de David N,Monreal AC,Kassuya CA,Antoniolli-Silva AC,Stefanello MÉ,Oliveira RJ

doi

10.1016/j.jep.2017.02.042

subject

Has Abstract

pub_date

2017-03-22 00:00:00

pages

205-208

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(16)30790-5

journal_volume

200

pub_type

杂志文章

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