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Anti-inflammatory, analgesic and wound healing activities of the leaves of Memecylon edule Roxb.

Abstract：

AIM OF THE STUDY:To determine the anti-inflammatory, analgesic and antioxidant activities of the leaves of Memecylon edule Roxb. used traditionally in Thailand. MATERIALS AND METHODS:Hexane, (Hex), ethyl acetate (EtOAc), methanol (MeOH) and 50% methanol (MeOH50) fractions of the dry leaves were tested in vitro for their interleukin-10 production; the most active fraction was further studied in vivo for its anti-inflammatory and analgesic activities using the ethylphenylpropiolate (EPP)-induced mouse ear edema and the writhing test with mice. All fractions except Hex were tested for their radical scavenging activity towards 1'-diphenyl-2-picrylhydrazyl radical (DPPH). RESULTS:The EtOAc showed the highest stimulation for interleukin-10 production. In the EPP test, this fraction was significantly active 30 min after topical application at all doses used (0.5, 1.0, 2.0mg/ear); after 4h and at 1.0mg/ear EtOAc was slightly less active (inhibition 47.8%) than the reference, indomethacin, at the same dose (62.4%). At 200mg/kg orally, the EtOAc caused a significant inhibition of the writhing response by 56.6% which was like indomethacin at 10mg/kg. EtOAc, MeOH and MeOH50 exhibited radical scavenging activity. The order of IC(50) values was: ascorbic acid (9.1 microg/mL)>trolox (11.6 microg/mL)>MeOH (46.9 microg/mL)>MeOH50 (152.1 microg/mL)>EtOAc (1742.2 microg/mL). CONCLUSION:The results provide support for the traditional use of Memecylon edule leaves in relieving inflammation and pain.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Nualkaew S,Rattanamanee K,Thongpraditchote S,Wongkrajang Y,Nahrstedt A

doi

10.1016/j.jep.2008.10.034

subject

Has Abstract

pub_date

2009-01-21 00:00:00

pages

278-81

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00624-7

journal_volume

121

pub_type

杂志文章

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