Hypoglycemic effect of Tournefortia hirsutissima L., on n-streptozotocin diabetic rats.

Abstract:

:The hypoglycemic effect of aqueous and butanolic extracts from Tournefortia hirsutissima (Boraginaceae) was determined on neonatal induced streptozotocin diabetic rats (n-STZ). Oral administration of water extracts at doses of 20 and 80mg/kg, and butanolic extracts (8 and 80mg/kg) significantly lowered the plasma glucose levels in diabetic rats within 3h. Glibenclamide was used as reference and showed similar hypoglycemic effect. Our results support the traditional use of the plant as a hypoglycemic agent; we observe a dose-dependent action of the extracts. HPLC analysis confirmed that the aqueous and butanolic extracts had the same chemical composition.

journal_name

J Ethnopharmacol

authors

Andrade-Cetto A,Revilla-Monsalve C,Wiedenfeld H

doi

10.1016/j.jep.2007.02.020

subject

Has Abstract

pub_date

2007-05-30 00:00:00

pages

96-100

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00098-0

journal_volume

112

pub_type

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