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Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants.

Abstract：

:Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastrus angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarinorum and C. bungei (Verbenaceae), Periploca callophylla and P. forrestii (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria rhynchophylla (Rubiaceae) were assessed for CNS activity against 18 radioligand receptor binding assays. The receptors used were alpha 1-, alpha 2- and beta-adrenoceptors, 5HT-1, 5HT-1A, 5HT-2, opiate, adenosine-1, benzodiazepine, Ca+2 channel, sulphonylureas, dopamine-1, dopamine-2, muscarinic, histamine-1, Na+/K+ ATPase, GABAA and GABAB. The results indicate that these ligand-receptor binding assays are useful for understanding the mode of action of herbal medicines and for bioassay guided fractionation of plant active ingredients.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhu M,Bowery NG,Greengrass PM,Phillipson JD

doi

10.1016/s0378-8741(96)01454-7

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

153-64

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(96)01454-7

journal_volume

54

pub_type

杂志文章

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