当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models.

Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Salvia L. species are widely used against wounds and skin infections in Turkish folk medicine. AIM OF THE STUDY:The aim of the present study is to evaluate wound healing activity of the ethanol (EtOH) extracts of Salvia cryptantha and Salvia cyanescens. MATERIALS AND METHODS:For the assessment of wound healing activity linear incision and circular excision wound models were employed on rats and mice. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol(®). Inhibition of tyrosinase, a key enzyme in skin aging, was achieved using ELISA microplate reader. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavenger effect, ferrous ion-chelating ability, and ferric-reducing antioxidant power (FRAP) tests. RESULTS AND CONCLUSIONS:The EtOH extract of Salvia cryptantha treated groups of animals showed 56.5% contraction, whereas the reference drug Madecassol(®) showed 100% contraction. On the other hand, the same extract on linear incision wound model demonstrated a significant increase (33.2%) in wound tensile strength as compared to other groups. The results of histopathological examination maintained the upshot of linear incision and circular excision wound models as well. These findings specify that Salvia cryptantha for wound healing activity can be appealed further phytochemical estimation for spotting its active components.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Süntar I,Akkol EK,Senol FS,Keles H,Orhan IE

doi

10.1016/j.jep.2011.02.022

subject

Has Abstract

pub_date

2011-04-26 00:00:00

pages

71-7

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00107-3

journal_volume

135

pub_type

杂志文章

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