当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Evaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systems.

Evaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systems.

Abstract：

:Paepalantine is an isocoumarin isolated from Paepalanthus vellozioides which showed antimicrobial activity in in vitro experiments. In the present study, paepalantine was tested for possible clastogenic and cytotoxic action. Cultures from different individuals were treated with paepalantine at concentrations of 20, 40 and 80 microg/ml. The effect of isocoumarin was also tested in an in vivo assay using Wistar rat bone marrow cells. Paepalantine was administered intraperitoneally at concentrations of 6.25, 12.5 and 25 mg/kg body weight. Under these conditions paepalantine did not have a clastogenic effect, but was significantly cytotoxic in the in vitro and in vivo mammalian cell systems tested in the present work.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Tavares DC,Varanda EA,Andrade FD,Vilegas W,Takahashi CS

doi

10.1016/s0378-8741(99)00061-6

keywords:

subject

Has Abstract

pub_date

1999-12-15 00:00:00

pages

115-20

issue

1-3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(99)00061-6

journal_volume

68

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Antimycobacterial activity of Citrullus colocynthis (L.) Schrad. against drug sensitive and drug resistant Mycobacterium tuberculosis and MOTT clinical isolates.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Citrullus colocynthis (Cucurbitaceae), a folk herbal medicine and traditionally used natural remedy for tuberculosis in India has been studied to validate its antitubercular activity against drug sensitive and drug resistant (including multidrug resistant) Mycobacterium tuberculosis and M...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.06.022

    authors： Mehta A,Srivastva G,Kachhwaha S,Sharma M,Kothari SL

    更新日期：2013-08-26 00:00:00

  • Anti-nociceptive activity of aqueous fraction from the MeOH extracts of Paederia scandens in mice.

    abstract：AIM OF THE STUDY:We examined the effects of the aqueous fraction (AF) on nociception models mice induced by the chemical and the thermal stimuli so as to elucidate the analgesic activity and provide scientific basis for the clinical use of Paederia scandens. MATERIALS AND METHODS:The AF of MeOH extract from P. scanden...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.011

    authors： Chu C,Huang Y,Chen YF,Wu JH,Rahman K,Zheng HC,Qin LP

    更新日期：2008-06-19 00:00:00

  • Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress.

    abstract：AIM OF STUDY:Diabetes mellitus is frequently combined with vascular diseases, which are associated with the expression of vascular endothelial growth factor (VEGF). An approach that can reverse the induction of VEGF by hyperglycemia may potentially benefit the outcome of diabetic patients. Therefore, in the present stu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.018

    authors： Qian S,Huo D,Wang S,Qian Q

    更新日期：2011-09-02 00:00:00

  • Protective effects of Poria cocos and its components against cisplatin-induced intestinal injury.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as dia...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113722

    authors： Zou YT,Zhou J,Wu CY,Zhang W,Shen H,Xu JD,Zhang YQ,Long F,Li SL

    更新日期：2021-04-06 00:00:00

  • Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.

    abstract：:Twenty plants, belonging to sixteen families, used in traditional New Caledonian and Vanuatu medicine for treatment of symptoms potentially related to tuberculosis (cough, fever or inflammation) were screened for antimycobacterial activity. We also screened an original endemic plant, Amborella trichopoda, only member ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.09.008

    authors： Billo M,Cabalion P,Waikedre J,Fourneau C,Bouttier S,Hocquemiller R,Fournet A

    更新日期：2005-01-04 00:00:00

  • Some phytochemical aspects of medicinal plant research.

    abstract：:Various aspects of medicinal plant research, i.e. collection of data, screening for biological activity and isolation and identification of active compounds are briefly discussed with special reference to phytochemical aspects. Based upon this some topics for further methodological research are presented. A strategy f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(89)90044-5

    authors： Verpoorte R

    更新日期：1989-02-01 00:00:00

  • Larvicidal activity of extracts from Quercus lusitania var. infectoria galls (Oliv.).

    abstract：:The present study indicates the efficacy of extracts and fractions of Quercus lusitania var. infectoria galls (Oliv.) as larvicidal agents and their possible use in biological control of Culex pipiens, the urban nuisance mosquito. Extracts and fractions were tested against second and fourth instar larvae. The LC(50) v...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00390-7

    authors： Redwane A,Lazrek HB,Bouallam S,Markouk M,Amarouch H,Jana M

    更新日期：2002-02-01 00:00:00

  • Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain.

    abstract：:Tribulus terrestris L. (Zygophyllaceae) have been used as an aphrodisiac both in the Indian and Chinese traditional systems of medicine. Administration of Tribulus terrestris extract (TT) increased sexual behaviour and intracavernous pressure both in normal and castrated rats and these effects were probably due to the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.030

    authors： Gauthaman K,Adaikan PG

    更新日期：2005-01-04 00:00:00

  • Zingansikpoongtang modulates beta-amyloid and IL-1beta-induced cytokine production and cyclooxygenase-2 expression in human astrocytoma cells U373MG.

    abstract：:Zingansikpoongtang (ZST) is a Korean herbal prescription, which has been successfully applied for the various neurodegenerative diseases. However, its effect remains unknown in the experimental models. In this study, we examined the effect of ZST on production of interleukin (IL)-6 and IL-8, and expression of cyclooxy...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.09.021

    authors： Kim SJ,Jeong HJ,Lee KM,Ryu HH,Lee KS,Moon BS,Cho KH,Kim HM

    更新日期：2005-01-04 00:00:00

  • Medicinal plants for gastrointestinal diseases among the Kuki-Chin ethnolinguistic groups across Bangladesh, India, and Myanmar: A comparative and network analysis study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Kuki-Chin is a composite ethnolinguistic group made up of many distinct groups and subgroups that are linked by a common history, culture, and population distribution in the Kuki-Chin region, shared geopolitically by Bangladesh, India, and Myanmar. This region is shown to be in a hots...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112415

    authors： Ong HG,Kim YD

    更新日期：2020-04-06 00:00:00

  • Ethnomedicinal uses of Momordicacharantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity.

    abstract：:Investigation of the traditional uses of Momordica charantia (Cucurbitaceae) in Togo (West Africa) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. There was a high degree of consensus (>50%) for use in the treatment of gastrointestinal and viral disease am...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.009

    authors： Beloin N,Gbeassor M,Akpagana K,Hudson J,de Soussa K,Koumaglo K,Arnason JT

    更新日期：2005-01-04 00:00:00

  • Antibacterial activity and in vitro anti-tumor activity of the extract of the larvae of the housefly (Musca domestica).

    abstract：:One of the significant characteristics of traditional Chinese medicine is the use of insects, other terrestrial arthropods and their products as drugs. In the present work, the extract of housefly (Musca domestica) larvae was studied by an agar well diffusion assay and minimum bactericidal concentration (MBC) determin...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.11.015

    authors： Hou L,Shi Y,Zhai P,Le G

    更新日期：2007-05-04 00:00:00

  • Effect of Momordica charantia on key hepatic enzymes.

    abstract：:The effect of Momordica charantia on certain key hepatic enzymes was investigated using male Sprague-Dawley rats as the animal model. Fruit juice and seed extract of Momordica charantia were administered orally at a daily dose of 1 ml/100 g body weight for 30 days under light ether anaesthesia while the control group ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)90074-4

    authors： Tennekoon KH,Jeevathayaparan S,Angunawala P,Karunanayake EH,Jayasinghe KS

    更新日期：1994-10-01 00:00:00

  • Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future.

    abstract：:Omic techniques have become key tools in the development of systems biology. As the holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new tendencies in Western medicine towards personalised medicine require in-depth knowledge of mechanisms of action and active compounds, the use of ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2012.01.055

    authors： Buriani A,Garcia-Bermejo ML,Bosisio E,Xu Q,Li H,Dong X,Simmonds MS,Carrara M,Tejedor N,Lucio-Cazana J,Hylands PJ

    更新日期：2012-04-10 00:00:00

  • Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb (Heshouwu, HSW) is commonly used in clinical medicine, while the hepatotoxicities of HSW are reported increasingly in recent years. Currently, researchers have demonstrated an essential role of Bile Acids (BAs) in liver diseases. The occurrence of hepatotoxicit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.12.007

    authors： Wei J,Chen J,Fu L,Han L,Gao X,Sarhene M,Hu L,Zhang Y,Fan G

    更新日期：2019-05-10 00:00:00

  • Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).

    abstract：:The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.10.018

    authors： Malairajan P,Gopalakrishnan G,Narasimhan S,Veni KJ,Kavimani S

    更新日期：2007-03-21 00:00:00

  • Cardiovascular effects of the South American medicinal plant Cecropia pachystachya (ambay) on rats.

    abstract：:Cecropia pachystachya is used in South America for relieving cough and asthma. In Argentina it is known as "ambay" and grows in the neotropical forests (Ntr C.p.) and in temperate hilly regions (Tp C.p.). To evaluate their cardiovascular profile, the effect of extracts obtained from plants growing in the neotropical r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.09.030

    authors： Consolini AE,Migliori GN

    更新日期：2005-01-15 00:00:00

  • The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).

    abstract：:The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies. The hexane extract of this plant was evaluated for cytotoxic activity against in vitro culture on P388 murine leukaemia cells and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00274-4

    authors： Choo CY,Chan KL,Sam TW,Hitotsuyanagi Y,Takeya K

    更新日期：2001-09-01 00:00:00

  • Improvement of the liver pathology by the aqueous extract and the n-butanol fraction of Sida pilosa Retz in Schistosoma mansoni-infected mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Sida pilosa Retz (Malvaceae) is a plant used in Africa for the treatment of intestinal helminthiasis, lower abdominal pains and dysmenorrhea. AIM OF THE STUDY:In order to determine the potential use of S. pilosa in the treatment of schistosomiasis mansoni, we evaluated the schistosomicid...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.01.017

    authors： Jatsa HB,Russo RC,Pereira CA,Aguilar EC,Garcia CC,Araújo ES,Oliveira JL,Rodrigues VF,de Oliveira VG,Alvarez-Leite JI,Braga FC,Louis-Albert Tchuem Tchuente,Kamtchouing P,Negrão-Corrêa DA,Teixeira MM

    更新日期：2016-03-02 00:00:00

  • Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions.

    abstract：:Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit of inducing a state of euphoria and subjective well-being by chewing Catha edulis prevails among the inhabitants of th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(93)90039-8

    authors： Ahmed MB,el-Qirbi AB

    更新日期：1993-08-01 00:00:00

  • Lippia: traditional uses, chemistry and pharmacology: a review.

    abstract：:The chemical composition, pharmacological activity and traditional uses of 52 species attributed to the genus Lippia (Verbenaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for the treatment of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-8741(01)00234-3

    authors： Pascual ME,Slowing K,Carretero E,Sánchez Mata D,Villar A

    更新日期：2001-08-01 00:00:00

  • Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual la...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.12.017

    authors： Singh D,Müller CP,Murugaiyah V,Hamid SBS,Vicknasingam BK,Avery B,Chear NJY,Mansor SM

    更新日期：2018-03-25 00:00:00

  • Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.

    abstract：AIM OF THE STUDY:To investigate the effect of tashinone IIA (TA) on intimal hyperplasia in a rat model of carotid artery balloon injury and on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fetal bovine serum (FBS) and its underlying mechanisms. MATERIALS AND METHODS:Carotid artery injur...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.03.021

    authors： Li X,Du JR,Yu Y,Bai B,Zheng XY

    更新日期：2010-05-27 00:00:00

  • Harpagide from Scrophularia protects rat cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury by decreasing endoplasmic reticulum stress.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Harpagide is the main ingredient in Scrophularia ningpoensis Hemsl which is used for the therapeutic purpose of treating encephalopathy. Harpagide has shown promise in the treatment of oxygen-glucose deprivation and reoxygenation (OGD/R)-induced brain injury. However, the underlying mecha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112614

    authors： Wang K,Lou Y,Xu H,Zhong X,Huang Z

    更新日期：2020-05-10 00:00:00

  • A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In contrast to other leguminous plants generally used as food, Rhynchosia volubilis Loureiro, a small soybean with a black seed coat, has been used as a traditional oriental remedy for various human diseases in Eastern Asia. In this study, we demonstrated the protective effect of R. volub...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.12.041

    authors： Kang SW,Kim KA,Lee CH,Yang SJ,Kang TK,Jung JH,Kim TJ,Oh SR,Jung SH

    更新日期：2018-04-06 00:00:00

  • Anna Pavala Sindhooram--an antiatherosclerotic Indian drug.

    abstract：:The procedure for the preparation of Anna Pavala Sindhooram (APS), a drug based on the concepts of Indian medicine for the prevention and reversal of the atherosclerotic disease process is described in detail. The uniformity in the composition of samples of the drug obtained in 10 batches, prepared over a period of 5 ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(83)90001-6

    authors： Shanmugasundaram KR,Seethapathy PG,Shanmugasundaram ER

    更新日期：1983-05-01 00:00:00

  • Traditional plants used for medicinal purposes by local communities around the Northern sector of Kibale National Park, Uganda.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The study was done to establish medicinal plants used in the treatment of various diseases by the people in the Northern sector of Kibale National Park in western Uganda. It was also aimed at establishing the plant parts used and the mode of preparation of remedies. These plants create a ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.044

    authors： Namukobe J,Kasenene JM,Kiremire BT,Byamukama R,Kamatenesi-Mugisha M,Krief S,Dumontet V,Kabasa JD

    更新日期：2011-06-14 00:00:00

  • The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.

    abstract：AIM OF THE STUDY:The objectives of this study were to investigate the adjuvant anti-tumor effects of Antrodia camphorate in human hepatoma cells (C3A and PLC/PRF/5) which are resistance to most anti-tumor agents, elucidate the possible regulation pathways, and measure the tumor growth and survival rate in xenograft-nud...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.05.001

    authors： Chang CY,Huang ZN,Yu HH,Chang LH,Li SL,Chen YP,Lee KY,Chuu JJ

    更新日期：2008-08-13 00:00:00

  • Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice.

    abstract：OBJECTIVE:To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice. MATERIALS AND METHODS:The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.11.023

    authors： Amat N,Upur H,Ablimit A,Matsidik A,Yusup A,Kijjoa A

    更新日期：2009-02-25 00:00:00

  • The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through the regulation of substance metabolism and energy metabolism in type 2 diabetic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Type 2 diabetes mellitus (T2DM) regarded as a "hot" disease in traditional Chinese medicine (TCM). Accordingly, TCM uses a cold drug or formula such as the Chinese herbal formulae "Yitangkang" (YTK) as a treatment. YTK exhibited a good clinical antidiabetic effect in several experiments. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.111942

    authors： Han X,Yang Y,Metwaly AM,Xue Y,Shi Y,Dou D

    更新日期：2019-07-15 00:00:00