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Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).

Abstract：

:The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of 300mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (52.94%), whereas standard drug sucralfate showed 94.85%. Toona ciliata extract showed protection index 43.0% in water immersion stress induced ulcer, whereas standard drug omeprazole showed protection index 100%.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Malairajan P,Gopalakrishnan G,Narasimhan S,Veni KJ,Kavimani S

doi

10.1016/j.jep.2006.10.018

subject

Has Abstract

pub_date

2007-03-21 00:00:00

pages

348-51

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00549-6

journal_volume

110

pub_type

杂志文章

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