Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:In African traditional medicine, Ageratum conyzoides has been used as purgative, febrifuge, anti-ulcer and wound dressing. To date there is no safety information about long term use of Ageratum conyzoides which contains pyrrolizidine alkaloids, a class of hepatotoxic and carcinogenic phytochemicals. This study aims to evaluate the 90 days subchronic toxicity and in vitro toxicity of Ageratum conyzoides. MATERIALS AND METHODS:Three groups of 8 rats (4 males and 4 females) received distilled water (control), 500 and 1000 mg/kg of the extract daily for 90 consecutive days by oral gavage. The animals were observed daily for abnormal clinical signs and death. Body weight, relative organ weight, haematological and biochemical parameters of blood as well as heart, kidney, liver and spleen tissues histology were evaluated. RESULTS:After 90 days administration, Ageratum conyzoides increased significantly (p<0.05) the relative weight of the liver, the spleen and kidney as compared to control group. Ageratum conyzoides increased also significantly (p<0.05) ALP, ALT, AST and blood glucose. Furthermore, an increase in the number of platelets associated with a normocytic and normochromic anaemia was observed. The cytotoxicity, determined by the MTT test and neutral red assay, has shown that the cytotoxicity of hydroalcoholic extract of Ageratum conyzoides and its total alkaloids was very close. CONCLUSIONS:Our results have shown that Ageratum conyzoides at 500 and 1000 mg/kg can induce liver, kidney and haematological disorders. These toxics effects can be attributed to its total alkaloids especially to pyrrolizidine alkaloids which are present in this plant.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Diallo A,Eklu-Gadegbeku K,Amegbor K,Agbonon A,Aklikokou K,Creppy E,Gbeassor Mdoi
10.1016/j.jep.2014.07.005subject
Has Abstractpub_date
2014-09-11 00:00:00pages
1214-8issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(14)00509-1journal_volume
155pub_type
杂志文章abstract::Southern Africa is inherently rich in flora, where the habitat and climatic conditions range from arid environments to lush, sub-tropical greenery. Needless to say, with such diversity in plant life there are numerous indigenous poisonous plants, and when naturalised exotic species and toxic garden varieties are added...
journal_title:Journal of ethnopharmacology
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abstract:AIM OF THE STUDY:Baicalin is an active compound originating from the root of Scutellaria baicalensis Georgi, which has been used for anti-inflammation, anti-bacteria, anti-hypertension, anti-allergy and sedation since ancient China, though the neuronal mechanisms involved in the sedative effect is still unclear. Baical...
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-07-14 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-05 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
abstract::Oxymatrine is one of the alkaloids extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.) with activities of anti-inflammation, inhibiting immune reaction, antivirus, protecting hepatocytes and antihepatic fibrosis. However, the effect of oxymatrine on acute lung injury (ALI) has not been known yet. In...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2005-04-08 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2010-09-15 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2016-08-22 00:00:00
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journal_title:Journal of ethnopharmacology
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pub_type: 历史文章,杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2009-01-21 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2014-06-11 00:00:00
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journal_title:Journal of ethnopharmacology
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doi:10.1016/j.jep.2011.05.030
更新日期:2011-09-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The substantial increase in diabetes cases worldwide has been a major public health problem, and the use of medicinal plants can be considered an interesting alternative to control the disease and its complications. Anacardium humile St. Hill. (Anacardiaceae) is a typical plant from the B...
journal_title:Journal of ethnopharmacology
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更新日期:2021-03-25 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2004-12-01 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2019-03-01 00:00:00
abstract::Rubi Fructus (RF), the dried, unripe fruit of Rubus coreanus M IQ. (Rosaceae), has been used to improve male reproductive function in traditional Korean medicine. In this study, we investigated the effects of RF on sperm parameters and expression of cAMP-responsive element modulator (CREM), which has a crucial role in...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-12-03 00:00:00
abstract::Ethomedical uses of the plant, Uraria picta (Leguminosae), in Nigeria include the control of ectoparasites in man and domestic animals. Total and fractionated extracts of this plant have been assessed for acaricidal activity on Ixodes ricinus. All the extracts were acaricidal to the test organisms. Methanolic extract ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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