Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:Serjania marginata Casar. (Sapindaceae) is a species traditionally known to be used for the treatment of gastric pain and inflammatory symptoms. AIM OF THIS STUDY:Due to the therapeutic importance of this species, this study investigated the toxicological effects of S. marginata leaves (AESM), after a single and a repeated exposure in rats. MATERIALS AND METHODS:For the acute toxicity test, 2000 mg/kg of AESM was administered to male and female rats by gavage, whereas for subacute toxicity test, 30, 150, or 750 mg/kg of AESM were used. RESULTS:No evidence of toxicity was observed in the animals acutely exposed to the extract, indicating that the LD50 is higher than 2000 mg/kg. After the repeated administration of AESM the hematological and biochemical parameters were unaltered, except the erythrocytes number and albumin levels in the exposed animals. Moreover, daily administration of this extract caused alteration on kidney histology. AESM also induced an increase of abnormal sperm, however the other reproductive parameters analyzed, in both sexes, were not altered by the treatment. CONCLUSION:Although AESM was not toxic after a single exposure, its use after prolonged periods affected some analyzed parameters, indicating that precautions should be taken when it is given over longer periods.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
da Silva Moreira S,Tamashiro LK,Jorge BC,da Silva Balin P,Heredia-Vieira SC,de Almeida GL,Cardoso CAL,Kassuya CAL,Arena ACdoi
10.1016/j.jep.2018.11.024subject
Has Abstractpub_date
2019-03-01 00:00:00pages
197-204eissn
0378-8741issn
1872-7573pii
S0378-8741(18)31687-8journal_volume
231pub_type
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