Abstract：
AIM OF THE STUDY:Withania aristata is an endemic plant used traditionally in Canary Islands as a diuretic. In this paper, we report on this pharmacological activity in several extracts of the dry vegetal material collected and the identification and diuretic activity of two withanolides, one of them previously not reported, isolated from the most active fraction. MATERIAL AND METHODS:Four Whitania aristata extracts at 100 mg/kg were orally administered to laboratory animals to evaluate their diuretic activity. From the most active fraction, two withanolides were isolated. Both and a mixture of them at 5 and 10 mg/kg were analyzed too as diuretics. Water excretion rate and content of Na(+) and K(+) electrolytes were measured in the urine of saline-loaded animals. RESULTS:Whitania aristata water fraction, the two withanolides and the mixture of these compounds displayed high diuretic activity, with a significant excretion of sodium and potassium ions in laboratory animals. CONCLUSIONS:This research supports the ethno-medicinal use of Whitania aristata as diuretic. This activity seems to be associated to the presence of a new type of natural diuretic agents, such as withaferin A and witharistatin.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Benjumea D,Martín-Herrera D,Abdala S,Gutiérrez-Luis J,Quiñones W,Cardona D,Torres F,Echeverri Fdoi
10.1016/j.jep.2008.12.014subject
Has Abstractpub_date
2009-06-22 00:00:00pages
351-5issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(08)00700-9journal_volume
123pub_type
杂志文章abstract：:Plants from Northern Nigeria with a history of use in both human and veterinary traditional medicine have been investigated for their antiviral activity and their cytotoxicity determined. Extracts were tested against poliovirus, astrovirus, herpes simplex viruses and parvovirus, using the microtitre plate inhibition t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(99)00049-5
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0378-8741(88)90226-7
更新日期：1988-01-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malaria infection is the second largest killer disease after HIV in Nigeria. Failure of the orthodox medications due to drug adulteration, high cost of procurement of antimalarial drugs and inconvenience experienced in the use of high dosage of the new antimalarial drug combination therap...
journal_title：Journal of ethnopharmacology
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Prostate cancer is a major problem worldwide and affects most men above the age of forty-five. Vernonia guineensis Benth. (Asteraceae) root decoction is used in folk medicine in Cameroon to treat a number of ailments including prostate cancer. The aim of this study was to provide a prelim...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS AND METHODS:HdCL was obtained in Crato-CE, Brazil. Qualitati...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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abstract：:Lavandulifolioside was detected for the first time in Leonurus cardiaca var. vulgaris [Moench] Briquet (Lamiaceae). The isolation was performed from the butanolic extract of the aerial parts and the identification by NMR and MS. The pharmacological properties of lavandulifolioside consist of significant negative chron...
journal_title：Journal of ethnopharmacology
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更新日期：2002-04-01 00:00:00
abstract：:The leaves of Jodina rhombifolia (Hook. & Arn.) Reissek (Santalaceae) are utilized as anti-alcoholic in Argentine folk medicine. This study was designed to investigate the anti-alcohol properties in adolescent male Wistar rats (postnatal day 29; 83-105 g of weight). We utilized the "self-administration model", which e...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2013-05-20 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Reynoutria japonica Houtt. has been used as a traditional medicine of cancer in East Asia for thousands of years. However, the mechanism of the anti-cancer effect of R. japonica has not been investigated at the molecular level. The regulation of intracellular signaling pathways by the ext...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2019-12-05 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional polyherbal preparations have been utilized in Sri Lanka since ancient times and have gained a wide acceptance throughout the country. Although an extensive body of evidence supports the use of traditional herbal mixtures in the treatment of diabetes mellitus, only a few polyhe...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113613
更新日期：2021-03-01 00:00:00
abstract：:The feeding of a fish extract, prepared by extracting whole fish with 80% ethanol, prevented abdominal, thoracic aorta and coronary atheroma in cholesterol-fed rabbits. Daily fish extract feeding reduced serum cholesterol and LDL-cholesterol levels by 41.8 and 38.0%, respectively. In addition, triglyceride levels were...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(94)90058-2
更新日期：1994-01-01 00:00:00
abstract：:While fish chemotherapy is not a common practice in México, folk medicine is usually well accepted by fish farmers. Empirical knowledge suggested that garlic should have anthelmintic properties. Various trials were carried out in Cyprinus carpio infested with Capillaria sp., using minced garlic and its extracts. An em...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(88)90152-3
更新日期：1988-12-01 00:00:00
abstract：:Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite gu...
journal_title：Journal of ethnopharmacology
pub_type： 历史文章,杂志文章
doi：10.1016/0378-8741(91)90109-q
更新日期：1991-04-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnoveterinary medicine is often assumed to be a subset of human medicinal knowledge. Here we investigate the possibility that some ethnoveterinary medicine rather originates from observations of animal self-medication. We document and analyze the ethnoveterinary medicine used by Karen m...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112823
更新日期：2020-09-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ocimum species are traditionally used for the treatment of anxiety, nerve pain, convulsions and a variety of neurodegenerative disorders. The present study was undertaken to evaluate the anti-amnesic effect of O. basilicum L., O. sanctum L. and O. gratissimum L. extracts using in-vitro an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.10.026
更新日期：2016-12-04 00:00:00
abstract：AIM OF THE STUDY:Asthma is a disease marked by airway inflammation. Petasites japonicus (Pj) is known as an herb for treating asthma, oxidant stress and gastric ulcer in traditional Oriental medicine. In this study, the inhibitory effects of Pj extract on asthmatic responses were examined both in vitro and in vivo. MA...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.10.038
更新日期：2011-01-27 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Based on traditional medicine, infusions of Bidens species (Asteraceae) have been successfully used in the treatment of acute and chronic enteritis. Additionally, ethnopharmacological reports demonstrating the gastrointestinal, gastroprotective, anti-inflammatory, antiulcerogenic and immu...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2020-09-15 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.06.027
更新日期：2010-09-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Eupatorium perfoliatum L. has been used traditionally for the treatment of fever, malaria and inflammation-associated diseases. Nowadays it is mostly used as immune activating remedy. The following study was performed to evaluate extracts with different polarity and defined lead-compounds...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.05.040
更新日期：2011-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications....
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2013.08.051
更新日期：2013-10-28 00:00:00
abstract：OBJECTIVE:To evaluate the anti-angiogenesis effect of total glucosides of Paeonia lactiflora Pall. METHODS:In this study, we determined the effect of TGP on the proliferation of human vascular endothelial cells through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and fluorescence-activated ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.09.053
更新日期：2010-02-17 00:00:00
abstract：AIM OF THE STUDY:Caryocar coriaceum Wittm. fruit pulp fixed oil (CCFO) has been widely employed by communities from Brazil Northeastern in the treatment of skin inflammation, respiratory affections, wound healing and muscle pain. In this study, we evaluated the topical effect of CCFO against different irritant agents i...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.07.002
更新日期：2011-07-14 00:00:00
abstract：:Aqueous, ethanolic and hexane fractions of Momordica cymbalaria fruits were prepared and given individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 h after the treatment. The aqueous extr...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(01)00324-5
更新日期：2001-11-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuzi and ganjiang are widely used as traditional Chinese medicines (TCM) in China, Korea, Japan, and many other southeast Asian countries for treating ulcerative colitis (UC), emesis and heart failure for more than 1800 years. However, the underlying mechanism of fuzi, ganjiang and fuzi-g...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2020-10-28 00:00:00
abstract：:Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for behavioral effects in mice. The extract did not induce any toxic effect when it was administered i.p. and orally. Sedative properties could be confirmed with high doses (100 mg of dried plant/kg, and more), by a decrease of behavi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(90)90055-x
更新日期：1990-05-01 00:00:00
abstract：:Investigations were carried out to evaluate the effect of Momordica charantia on the glucose tolerance of maturity onset diabetic patients. The fruit juice of M. charantia was found to significantly improve the glucose tolerance of 73% of the patients investigated while the other 27% failed to respond. ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(86)90116-9
更新日期：1986-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Hancornia speciosa Gomes are traditionally used to treat diabetes in Brazil. The aim of the study is to evaluate the potential anti-diabetic effect of Hancornia speciosa extract and derived fractions. MATERIALS AND METHODS:The ethanolic extract from Hancornia speciosa leave...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.11.050
更新日期：2015-02-23 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders from ancient clinic. The aim of the study was to explore the involvement of inflammation or inflammatory markers in the antidepressant-like effects of XBXT-2. MATERIALS ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.01.022
更新日期：2015-04-02 00:00:00
