Abstract：
AIM OF THE STUDY:To investigate the antihypertensive fractions of Eucommia ulmoides Oliv. and their underlying mechanisms in spontaneously hypertensive rats (SHRs). MATERIALS AND METHODS:In vivo study, Eucommia ulmoides lignans (EuL) and Eucommia ulmoides iridoids (EuI) were administrated to Sprague-Dawley (SD) rats and SHRs, and their blood pressures were measured. Plasma level of nitric oxide (NO) was measured by colorimetric method, and renin activity (RA) and plasma concentration of angiotensin II (Ang II) were measured by radioimmunoassay. In vitro study, rat mesenteric artery was treated with EuL and the vessel relaxation responses were determined. RESULTS:EuL could lower blood pressures of both SD rats and SHR dose-dependently by either intravenous (i.v.) or intragastric (i.g.) administration, but EuI failed to affect blood pressure in the two kinds of rats. Meanwhile, no synergistic effect was observed with the combination of EuL and EuI. The plasma level of NO in SHR treated with EuL 300 mg/kg twice a day was markedly increased. Both plasma RA and Ang II level were decreased with long-term oral treatment of EuL 150 and 300 mg/kg twice a day. In perfusion experiment, EuL relaxed mesenteric artery quickly and dose-dependently and the effect on the artery with and without endothelium was the same. CONCLUSIONS:EuL may be the effective fraction to lowering blood pressure and its antihypertensive effect is probably associated with regulating NO and renin-angiotensin system (RAS) and directly relaxing artery.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Luo LF,Wu WH,Zhou YJ,Yan J,Yang GP,Ouyang DSdoi
10.1016/j.jep.2010.03.019subject
Has Abstractpub_date
2010-05-27 00:00:00pages
238-43issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(10)00181-9journal_volume
129pub_type
杂志文章abstract：:The Dominican Republic has an extension of 48 442 km2. It occupies the eastern portion of the island of Hispaniola and is the second in size within the Greater Antilles. The floral resources of the Island have been extensively exploited without an adequate management policy. This has led to the destruction of about 90...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(95)01356-3
更新日期：1996-04-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The paper presents information about the earliest botanical work from Poland, Warsavia physice illustrata which takes bryophytes into account. It was elaborated by a German physician Christian Heinrich Erndtel and issued in 1730 in Dresden. That time understanding of bryophytes was imprec...
journal_title：Journal of ethnopharmacology
pub_type： 历史文章,杂志文章
doi：10.1016/j.jep.2014.03.025
更新日期：2014-05-14 00:00:00
abstract：:Galangin is one of the active antimicrobial principles of propolis or 'bee glue' and Helichrysum aureonitens, a perennial herb used by South African indigenes to treat infection. The effect of this compound and antibacterial agents with known mechanisms of action upon the cytoplasmic membrane integrity of Staphylococc...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2005.04.014
更新日期：2005-10-03 00:00:00
abstract：AIM OF THE STUDY:This present study was carried out to evaluate the anti-inflammatory and analgesic effects of 85% ethanol extract (EE) of Commiphora myrrha and its different fractions partitioned with petroleum ether extract (EPE), ethyl acetate extract (EEA), n-butanol extract (EBu), and the water extract (ECY). More...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.12.003
更新日期：2011-03-24 00:00:00
abstract：:An ethnobotanical study was carried out in six villages in the Bunda district, Mara Region, Tanzania, where the use of plants still has a special meaning to the society, in the treatment of various diseases. Information was obtained from the traditional healers and other experienced persons, having some knowledge on m...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.07.006
更新日期：2007-09-25 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Phragmanthera incana (Schum) Balle is a member of the African mistletoes that has been reported to be used in ethnomedicine for the treatment of hypertension. AIM:The aim of this study was to investigate the antihypertensive effect of Phragmanthera incana leaf ethanol extract (PILEE) in ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112888
更新日期：2020-07-15 00:00:00
abstract：:Essential oils of seven Moroccan Labiatae were chemically analysed by GC-MS and evaluated for their in vitro antifungal activity against Botrytis cinerea. Among them, Origanum compactum and Thymus glandulosus greatly inhibited the growth of the mycelium. The inhibition of Botrytis cinerea was 100% for both oils at 100...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00275-7
更新日期：2003-11-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Chyawanprash (CP), a traditional immune booster recipe, has a long history of ethnic origin, development, household preparation and usage. There are even mythological stories about the origin of this recipe including its nomenclature. In the last six decades, CP, because of entrepreneuria...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2016.07.078
更新日期：2017-02-02 00:00:00
abstract：AIM OF THE STUDY:Ardisia species, notably A. compressa, are used in some regions of the world as food or in traditional medicine for prevention and treatment of certain health conditions including liver disease. We investigated the chemical composition and relative anticancer potential of six Ardisia species [A. japoni...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2010-08-09 00:00:00
abstract：AIM OF THE STUDY:Labisia pumila has rejuvenating properties that help women to regain the strength and vigour after giving birth (Burkill, 1935) leading us to speculate that Labisia pumila might also modulate the immune matrix as it is one of the important aspect of healthy state of the living body. MATERIALS AND METH...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.08.039
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abstract：:Twelve pure compounds originally obtained through a systematic chemotaxonomical study with Mexican plants of the Asteraceae, were subjected to a cytotoxic and in vitro antimicrobial screening. Three different cell lines in culture (KB, KB-VI and P388) were used in the cytotoxicity assay, while antimicrobial activity w...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(94)90019-1
更新日期：1994-03-01 00:00:00
abstract：:While fish chemotherapy is not a common practice in México, folk medicine is usually well accepted by fish farmers. Empirical knowledge suggested that garlic should have anthelmintic properties. Various trials were carried out in Cyprinus carpio infested with Capillaria sp., using minced garlic and its extracts. An em...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(88)90152-3
更新日期：1988-12-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The presence of nitrite in the human diet was thought to constitute a hazard as secondary nitrosamines are known to cause gastric cancers. MATERIALS AND METHODS:Recent publications on the physiology of serum nitrite have been consulted. PROBLEMS:Nitrite is added to some foodstuffs as an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.09.040
更新日期：2015-06-05 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113423
更新日期：2021-02-10 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.08.018
更新日期：2008-11-20 00:00:00
abstract：:In this study, the effect of regular khat chewing on serum glucose and C-peptide levels were investigated in both healthy male individuals and type 2 diabetic patients. The results presented show the levels of glucose and C-peptide of healthy individuals to be non-significantly different between khat and non-khat chew...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(03)00035-7
更新日期：2003-05-01 00:00:00
abstract：AIM OF THE STUDY:Zanthoxylum rhoifolium Lam. (Rutaceae) is locally known as "mamica de cadela", and its bark is popularly used for toothache and earache. The objective of this study was to investigate the antinociceptive effect of the ethanolic extract from this species' stem bark (EtOH), its fractions of partition (he...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.03.009
更新日期：2010-05-27 00:00:00
abstract：:Chemoprevention of free radical-mediated diseases including cancer by natural products is an emerging discipline due to its wider applicability and acceptance. The present study deals with the chemopreventive effect of Salix caprea against phorbol ester-induced oxidative stress and tumor promotion in murine skin. In t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2003.12.028
更新日期：2004-04-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.03.045
更新日期：2017-07-12 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.07.003
更新日期：2019-05-10 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1996-07-05 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.02.027
更新日期：2008-05-22 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.09.049
更新日期：2012-12-18 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as "Ashwagandha". A number of published reports suggest various uses for WA including its function as an anti-inflammatory and anti-angiogenic drug molecule. The effects ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.09.024
更新日期：2015-12-04 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.04.036
更新日期：2011-06-14 00:00:00
abstract：:Propolis collected from a cerrado area in Minas Gerais State, Brazil, was subjected to chromatography on silica gel column and to partition between immiscible solvents. Propolis aqueous-ethanolic extract and fractions obtained were tested for inhibitory activity against periodontitis-causing bacteria. All of the assay...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2002-04-01 00:00:00
abstract：:Based on ethnopharmacological literature, 17 species of medicinal plants used in the traditional medicine in Papua New Guinea were collected. Extracts of different polarities were tested in a preliminary biological screening for their antimicrobial (Escherichia coli, Bacillus subtilis, Micrococcus luteus and Penicilli...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(95)01315-6
更新日期：1995-12-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:As an important medicinal material constituting a variety of traditional Chinese medicine prescriptions, Nepeta angustifolia C. Y. Wu was used as a folk medicine to treat various vascular-related diseases including apoplexia, and cerebral haemorrhage in Tibet, China. Our previous studies ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112771
更新日期：2020-06-12 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Hancornia speciosa Gomes are traditionally used to treat diabetes in Brazil. The aim of the study is to evaluate the potential anti-diabetic effect of Hancornia speciosa extract and derived fractions. MATERIALS AND METHODS:The ethanolic extract from Hancornia speciosa leave...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2015-02-23 00:00:00
abstract：:Montanoa tomentosa (zoapatle) is a Mexican plant popularly used for antifertility purposes and with promising characteristics for the development of a new oral contraceptive agent with uteroevacuant properties. In a previous pharmacological report we established the ambivalent myometrial response to zoapatle leaves aq...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(84)90098-9
更新日期：1984-06-01 00:00:00
