当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Studies on the toxicity of gambogic acid in rats.

Studies on the toxicity of gambogic acid in rats.

Abstract：

AIM:To study the chronic toxicity of gambogic acid (GA), the major active ingredient of gamboges, a brownish to orange resin extracted from the Garcinia hanburyi (family Guttiferae) in Southeast Asia, using Sprague-Dawley rat as an animal model and provide further theoretical support for clinical applications of this promising natural anticancer agent. METHODS:GA was administered orally at dosages of 120, 60 and 30 mg/kg once every other day for a total of 13 weeks. Then we carried out the chronic toxicity studies including general body parameters, hematological, serum biochemistry, histopathological, and viscera examination. RESULTS:The results from the studies demonstrated that rats treated with high dose (120 mg/kg) of GA for a long time can lead to the damage on the kidney and liver. An innocuous dose was established to be 60 mg/kg after administration to rats for a total of 13 weeks at a frequency of one administration every other day. This dose was approximately 18.0 (body weight) or 9.6 (body surface area) times higher then that of the dose (200mg/60 kg, every other day) used for human trials. CONCLUSIONS:The studies demonstrated that the toxicity targets in the rats were the kidney and liver. These results provide further theoretical support for clinical applications of this promising natural anticancer agent.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Qi Q,You Q,Gu H,Zhao L,Liu W,Lu N,Guo Q

doi

10.1016/j.jep.2008.02.027

subject

Has Abstract

pub_date

2008-05-22 00:00:00

pages

433-8

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00103-7

journal_volume

117

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae).

    abstract：AIMS OF THE STUDY:The South American mint genus Minthostachys is of great importance in the Andes as a medicinal, aromatic, culinary and commercial essential oil plant. After decades of taxonomic confusion and virtual indeterminability of specimens, new systematic and taxonomic work has been conducted in recent years. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.05.030

    authors： Schmidt-Lebuhn AN

    更新日期：2008-08-13 00:00:00

  • In vitro purgative effect of Ruellia praetermissa. Sceinf.ex.Lindau (Acanthaceae).

    abstract：:Methanol, ethylacetate and aqueous extracts of Ruellia praetermissa initiated spontaneous contractions in the quiescent and increased contraction on the electrically stimulated ileal strip at a concentration of 30 microg/ml. The extracts produced concentration-related contractions both in amplitude and tone up till 75...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00204-x

    authors： Salah AM,Dongmo AB,Kamanyi A,Bopelet M,Vierling W,Wagner H

    更新日期：2000-09-01 00:00:00

  • Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice.

    abstract：AIM OF THE STUDY:The extract of the leaves of Alchornea cordifolia (AC) is extensively used in ethnomedicine for ulcers, rheumatic pains, febrile convulsions and for enhancing physical performance. In this study, the anti-stress and anticonvulsant activities of the aqueous leaf extract of Alchornea cordifolia were inve...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.11.023

    authors： Umukoro S,Aladeokin AC

    更新日期：2010-02-17 00:00:00

  • Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. Brown.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Salvia plebeia R. Brown has been used for the treatment of a variety of inflammatory diseases, cold and tumors in many countries, including Korea and China. AIM OF THE STUDY:This study aimed to assess anti-inflammatory and related activities of an ethanol extract (SPEE) prepared from the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.08.031

    authors： Jung HJ,Song YS,Lim CJ,Park EH

    更新日期：2009-11-12 00:00:00

  • Comparing medicinal plant knowledge using similarity indices: a case of the Brou, Saek and Kry in Lao PDR.

    abstract：BACKGROUND:Medicinal plant traditional knowledge is one of the most widely known traditional ecosystem services, as it provides primary healthcare, contributes to subsistence livelihoods, and for its potential value as a source of novel pharmaceuticals. People living in close contact with their surroundings for many ge...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.017

    authors： de Boer HJ,Lamxay V,Björk L

    更新日期：2012-05-07 00:00:00

  • Chrysoeriol and other polyphenols from Tecoma stans with lipase inhibitory activity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tecoma stans is traditionally used by several ethnical groups in Mexico and Central America to treat diabetes. This species is mentioned in the majority of the ethnopharmacological studies compiled in Mexico focused in medicinal plants used as anti-diabetic treatment. AIM OF THE STUDY:Re...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.03.014

    authors： Ramirez G,Zamilpa A,Zavala M,Perez J,Morales D,Tortoriello J

    更新日期：2016-06-05 00:00:00

  • Antimutagenic potential of homoisoflavonoids from Muscari racemosum.

    abstract：:The potential antimutagenic effect of the plant extract of Muscari racemosum bulbs, rich on 3-benzylidene-4-chromanones, was evaluated on three genetic model organisms. The mixture of three homoisoflavonoids was applied together with diagnostic mutagens in the Ames assay on four bacterial strains Salmonella typhimuriu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00135-6

    authors： Miadoková E,Masterová I,Vlcková V,Dúhová V,Tóth J

    更新日期：2002-08-01 00:00:00

  • Ethanol extraction preparation of American ginseng (Panax quinquefolius L) and Korean red ginseng (Panax ginseng C.A. Meyer): differential effects on postprandial insulinemia in healthy individuals.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ginsenosides are the proposed bioactive constituent of ginseng, especially for the attenuation of postprandial glycemia (PPG). The efficacious proportion of total and specific ginsenosides, remains unknown. Alcohol extraction of whole ginseng root can be used to selectively manipulate the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2014.10.057

    authors： De Souza LR,Jenkins AL,Jovanovski E,Rahelić D,Vuksan V

    更新日期：2015-01-15 00:00:00

  • Hepatoprotective effect of total flavonoids of Mallotus apelta (Lour.) Muell.Arg. leaf against carbon tetrachloride-induced liver fibrosis in rats via modulation of TGF-β1/Smad and NF-κB signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Mallotus apelta (Lour.) Muell.Arg. is a well-known traditional Chinese medicine (TCM) used for anti-inflammatory, hemostasis and chronic hepatitis. AIM:The purpose of this study was to explore the antifibrotic effect of total flavonoids of Mallotus apelta leaf (TFM) and its potential...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112714

    authors： Zhang B,Lai L,Tan Y,Liang Q,Bai F,Mai W,Huang Q,Ye Y

    更新日期：2020-05-23 00:00:00

  • Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide.

    abstract：:The vasorelaxant effect of garlic (Alium sativum L.) has been suggested to be partially mediated through endothelium. The present study was designed to evaluate the role of various endothelium-mediated mechanisms in vasorelaxant response of garlic on isolated aortic rings of rats. In tissues precontracted with phenyle...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.06.001

    authors： Ashraf MZ,Hussain ME,Fahim M

    更新日期：2004-01-01 00:00:00

  • Ginkgo biloba extracts for tinnitus: More hype than hope?

    abstract：:The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2005.05.032

    authors： Smith PF,Zheng Y,Darlington CL

    更新日期：2005-08-22 00:00:00

  • Medical ethnobotany survey in Martinique.

    abstract：:From September 1990 to December 1994, the authors conducted an ethnobotanical survey within the population of Martinique. Two hundred and sixty-one plants used for medicinal purposes were gathered. It was possible to identify 251 species (96%). Traditional medicinal practices, although threatened by the modern pharmac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(96)01425-0

    authors： Longuefosse JL,Nossin E

    更新日期：1996-09-01 00:00:00

  • Antiinflammatory activity of extracts from Aloe vera gel.

    abstract：:We studied the effects of aqueous, chloroform, and ethanol extracts of Aloe vera gel on carrageenan-induced edema in the rat paw, and neutrophil migration into the peritoneal cavity stimulated by carrageenan. We also studied the capacity of the aqueous extract to inhibit cyclooxygenase activity. The aqueous and chloro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(96)01476-6

    authors： Vázquez B,Avila G,Segura D,Escalante B

    更新日期：1996-12-01 00:00:00

  • The immunostimulatory effects and chemical characteristics of heated honey.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine (TCM), honey has been used as an additive in the heat-processing of herbal medicines to enhance their immunostimulatory activities. AIM OF THE STUDY:We investigated the immunostimulatory activity of heated honey in vitro and in vivo. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.09.019

    authors： Ota M,Ishiuchi K,Xu X,Minami M,Nagachi Y,Yagi-Utsumi M,Tabuchi Y,Cai SQ,Makino T

    更新日期：2019-01-10 00:00:00

  • Protective effects of Zhibai Dihuang Wan on renal tubular cells affected with gentamicin-induced apoptosis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zhibai Dihuang Wan (ZDW) is an ancient traditional Chinese medicine composed of eight herbal ingredients and has been used to treat chronic kidney inflammation and diabetes for thousands of years. Nonetheless, the influence of ZDW on acute kidney injury is still unknown. We intended to id...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.11.031

    authors： Hsu YH,Chen TH,Wu MY,Lin YF,Chen WL,Cheng TH,Chen CH

    更新日期：2014-01-01 00:00:00

  • Evaluation of some pharmacological activities of Eugenia uniflora L.

    abstract：:In view of the extensive use of Eugenia uniflora in folk medicine, different extracts of dried and fresh leaves of the plant were assayed to test its possible pharmacological activities. The infusion of fresh leaves had a highly significant anti-inflammatory effect when administered p.o. to rats 1 h before subplantar ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01178-8

    authors： Schapoval EE,Silveira SM,Miranda ML,Alice CB,Henriques AT

    更新日期：1994-12-01 00:00:00

  • Artemisia biennis Willd.: Anti-Nociceptive effects and possible mechanisms of action.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Artemisia biennis Willd. (Dermane in Persian) has been used as an antinociceptive remedy in Iranian folkloric medicine. OBJECTIVE:The aim of the present study was to evaluate the anti-nociceptive effects of Artemisia biennis Willd. aerial part essential oil (ABAEO) on male Swiss mice. M...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113604

    authors： Zarei M,Ahmadimoghaddam D,Mohammadi S

    更新日期：2021-03-25 00:00:00

  • (2S)-naringenin from Typha angustata inhibits vascular smooth muscle cell proliferation via a G0/G1 arrest.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Typha angustata is used in traditional Chinese medicine for a variety of clinical disorders. Its pharmacological actions include beneficial effects on hyperlipidemia and myocardial infarction, as well as labor-inducing and antibacterial effects. AIM OF THE STUDY:We investigated the mecha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.12.038

    authors： Lee JJ,Yi H,Kim IS,Kim Y,Nhiem NX,Kim YH,Myung CS

    更新日期：2012-02-15 00:00:00

  • Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.

    abstract：:Since ages Mallotus peltatus (Geist) Muell. Arg. var acuminatus (Euphorbiaceae) leaf and stem bark is used in folk medicine to cure intestinal ailments and skin infections. In several intestinal ailments, localized inflammation is of common occurrence and hence we have evaluated the antimicrobial as well as anti-infla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00165-4

    authors： Chattopadhyay D,Arunachalam G,Mandal AB,Sur TK,Mandal SC,Bhattacharya SK

    更新日期：2002-10-01 00:00:00

  • Global medicinal uses of Euphorbia L. (Euphorbiaceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The genus Euphorbia (spurges, Euphorbiaceae) is the third largest genus of flowering plants, with almost 2000 species. Its exceptional diversity of growth forms and near-cosmopolitan distribution have attracted human interest since ancient times. For instance in Australia, topical applica...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2015.10.025

    authors： Ernst M,Grace OM,Saslis-Lagoudakis CH,Nilsson N,Simonsen HT,Rønsted N

    更新日期：2015-12-24 00:00:00

  • Role of Syzygium cumini seed extract in the chemoprevention of in vivo genomic damage and oxidative stress.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:[corrected] The seeds of Syzygium cumini, Skeels (Jamun) are extensively used in India for treatment of diabetes and other ailments. AIM OF THE STUDY:The aim of this work was to assess the role of Jamun seed extract (JSE) as a chemoprotective agent against in vivo oxidative stress and ge...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.12.014

    authors： Arun R,Prakash MV,Abraham SK,Premkumar K

    更新日期：2011-03-24 00:00:00

  • Hepatoprotective potential of standardized Ficus species in intrahepatic cholestasis rat model: Involvement of nuclear factor-κB, and Farnesoid X receptor signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ficus is an important commercial crop not only for its nutritive value but also, for its medicinal value. Several Ficus species have been traditionally used in the Egypt, Indian and Chinese as carminative, astringent, antibacterial, hepatoprotective, and hypolipidemic agents. AIM OF THE ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.026

    authors： El-Hawary SS,Ali ZY,Younis IY

    更新日期：2019-03-01 00:00:00

  • Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Hancornia speciosa Gomes are popularly used in Brazil to treat diabetes and hypertension. Cardiovascular diseases are the main cause of death worldwide and their incidences are increasing in Brazilian population. The present study aimed to investigate the hypotensive effect ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.06.031

    authors： Silva GC,Braga FC,Lima MP,Pesquero JL,Lemos VS,Cortes SF

    更新日期：2011-09-01 00:00:00

  • Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lignosus rhinocerus (Tiger Milk mushroom) is distributed in South China, Thailand, Malaysia, Indonesia, Philippines and Papua New Guinea. In Malaysia, it is the most popular medicinal mushroom used by the indigenous communities to relieve fever, cough, asthma, cancer, food poisoning and a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.02.027

    authors： Lee SS,Enchang FK,Tan NH,Fung SY,Pailoor J

    更新日期：2013-05-02 00:00:00

  • Preliminary phytochemical, pharmacological and antibacterial studies of the alkaloidal extracts of the leaves of Synclisia scabrida Miers.

    abstract：:Preliminary phytochemical investigation of the leaves of Synclisia scabrida indicated the presence of two alkaloids in the water extracts and five alkaloids in the ethanol extracts. The alkaloidal fraction obtained from the cold ethanol extract furnished on column-chromatography, a homogeneous amorphous solid which ha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90029-2

    authors： Sokomba E,Wambebe C,Chowdhury BK,Iriah J,Ogbeide ON,Orkor D

    更新日期：1986-11-01 00:00:00

  • Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional therapy with Chinese medicine, hydroxysafflor yellow A (HSYA), a main active component isolated from the dried flower of Carthamus tinctorius L., is the principal efficiency ingredient of Safflor Yellow Injection. Now HSYA has been demonstrated to have good pharmacological ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.025

    authors： Xu RA,Xu ZS,Ge RS

    更新日期：2014-02-12 00:00:00

  • The traditional uses, phytochemistry, and pharmacology of Stemona species: A review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants of genus Stemona (Stemonaceae) have been long used locally and traditionally in many South and East Asian counties to relieve cough, dispel phlegm, prevent asthma, control pests, diminish inflammation, decrease pain, and treat some cutaneous diseases. AIM OF STUDY:This review prov...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113112

    authors： Liu Y,Shen Y,Teng L,Yang L,Cao K,Fu Q,Zhang J

    更新日期：2021-01-30 00:00:00

  • Cancer chemopreventive activity of compounds isolated from Waltheria indica.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Waltheria indica L. is traditionally used in several countries against inflammatory related diseases and cancer, mainly as a decoction of the aerial parts. AIM OF THE STUDY:The transcription factor NF-κB is known to induce tumor promotion and progression and is considered a major player ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.048

    authors： Monteillier A,Cretton S,Ciclet O,Marcourt L,Ebrahimi SN,Christen P,Cuendet M

    更新日期：2017-05-05 00:00:00

  • In vitro studies on dissolved substance of cinnabar: chemical species and biological properties.

    abstract：UNLABELLED:Cinnabar is one of traditional Chinese medicines widely used in many Asian countries. It is also a medicine with potential toxicity especially when taking overdose. Up to date, studies on the mechanism of the biological activity of cinnabar were still insufficient. AIM OF THE STUDY:To investigate the possib...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.06.018

    authors： Zhou X,Zeng K,Wang Q,Yang X,Wang K

    更新日期：2010-08-19 00:00:00

  • The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gypenosides are major constituents in Gynostemma pentaphyllum (Thunb.) Makino. Previous studies have shown that gypenosides isolated from G. pentaphyllum possess inhibitory effect on the growth of cancer cells, especially A549 cells, with structure-activity relationship (SAR). However, th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.03.012

    authors： Xing SF,Liu LH,Zu ML,Ding XF,Cui WY,Chang T,Piao XL

    更新日期：2018-06-12 00:00:00