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Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice.

Abstract：

AIM OF THE STUDY:The extract of the leaves of Alchornea cordifolia (AC) is extensively used in ethnomedicine for ulcers, rheumatic pains, febrile convulsions and for enhancing physical performance. In this study, the anti-stress and anticonvulsant activities of the aqueous leaf extract of Alchornea cordifolia were investigated in mice. MATERIALS AND METHODS:The anti-stress activity was assessed based on the ability of the extract to alter the duration of immobility, in the forced swim endurance test, whilst a picrotoxin-treated animal, was employed as the model for convulsive seizures. RESULTS:The extract (100-400 mg/kg) given orally was found to significantly (p<0.05) reduce the duration of immobility, which suggest an anti-stress/anti-fatigue property. However, AC when tested at doses between 100 and 400 mg/kg did not prevent convulsions induced by picrotoxin in mice. The acute toxicity study carried out in mice revealed that the extract was well tolerated by the animals, as no death was observed at oral doses of 500-4000 mg/kg. CONCLUSIONS:The results of this preliminary study provide evidence, which may support the use of Alchornea cordifolia against stress or fatigue in ethnomedicine.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Umukoro S,Aladeokin AC

doi

10.1016/j.jep.2009.11.023

subject

Has Abstract

pub_date

2010-02-17 00:00:00

pages

768-70

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(09)00730-2

journal_volume

127

pub_type

杂志文章

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