当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > In vitro growth stimulatory and in vivo wound healing studies on cycloartane-type saponins of Astragalus genus.

In vitro growth stimulatory and in vivo wound healing studies on cycloartane-type saponins of Astragalus genus.

Abstract：

AIM OF THE STUDY:The present study was undertaken to evaluate the wound healing effects of the four chief saponins of Astragalus species [cycloastragenol (CA), astragaloside IV (AG), cyclocephaloside I (CCI) and cyclocanthoside E (CCE)]. MATERIAL AND METHODS:Effects of cell viability and proliferation of the isolated compounds were evaluated by the MTT assay on human keratinocyte. The wound healing activity was studied by using in vitro wound healing, proliferation and migration scratch assay. In order to see in vivo effectiveness of the compounds, an animal study with Sprague-Dawley male rats at the age of 12 weeks was carried out, and then the main histological outcomes were investigated to observe reepithelization, neovascularization, and presence of inflammatory cells, granulation tissue amount and maturation. RESULTS:All the compounds increased both fibroblast proliferation and migration, but the effects were much superior for CA at 1 ng/ml concentration. Among the compounds, based on the histological findings, 5% CA preparation was found to be the most remarkable in vivo wound healing agent showing greater cell density, more regularly organized dermis and more newly formed blood vessels. CONCLUSION:Results of this study indicate that the cycloartane-type saponins are the principal constituents responsible for wound healing activities of the roots of Astragalus species substantiating its use in traditional medicine.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Sevimli-Gür C,Onbaşılar I,Atilla P,Genç R,Cakar N,Deliloğlu-Gürhan I,Bedir E

doi

10.1016/j.jep.2011.01.030

subject

Has Abstract

pub_date

2011-04-12 00:00:00

pages

844-50

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00044-4

journal_volume

134

pub_type

杂志文章

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