Abstract：
AIM:CGX, a modified traditional Chinese herbal drug whose name means "liver cleaning," is used to treat various liver disorders. This study investigated the protective effects of CGX and its mechanisms. MATERIAL AND METHODS:After pretreating ICR mice twice daily with CGX (po, 50 or 100mg/kg) or distilled water for three consecutive days, acute liver injury was induced by a single injection of CCl(4) (ip, 10mL/kg of 0.2% in olive oil) (n=8 per group). RESULTS:Pretreatment with CGX significantly attenuated the elevation in biochemical parameters, such as alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) in serum, and the malondialdehyde concentrations in liver tissue. Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione (GSH) content, but not superoxide dismutase (SOD) activity, and it inhibited the CCl(4)-induced high expression of iNOS and TNF-alpha in hepatic tissue. CONCLUSION:This study showed that CGX has hepatoprotective effects against free radical-induced acute injury via primarily antioxidative properties.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Hu XP,Shin JW,Wang JH,Cho JH,Son JY,Cho CK,Son CGdoi
10.1016/j.jep.2008.07.042subject
Has Abstractpub_date
2008-10-30 00:00:00pages
51-5issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(08)00410-8journal_volume
120pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2014-08-08 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2016-06-20 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2010-03-24 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lepidium meyenii (Maca) is traditionally employed in the Andean region for its supposed fertility benefits. This study investigated the effect of Maca on the serum pituitary hormone levels during the pro-oestrus phase. MATERIALS AND METHODS:Maca powder was made from the tubers of Lepidiu...
journal_title：Journal of ethnopharmacology
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