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Anti-inflammatory activity of the bark of Hippocratea excelsa.

Abstract：

:The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a protective effect on heat-induced erythrocyte lysis at concentrations of 25, 50 and 100 micrograms/ml. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB). It may be inferred that the ethanol extract is effective against both exudative-proliferative and chronic phases of inflammation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Perez RM,Perez S,Zavala MA,Salazar M

doi

10.1016/0378-8741(95)01257-e

subject

Has Abstract

pub_date

1995-07-07 00:00:00

pages

85-90

issue

2

eissn

0378-8741

issn

1872-7573

pii

0378-8741(95)01257-E

journal_volume

47

pub_type

杂志文章

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