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Effects of Fagonia cretica L. constituents on various haematological parameters in rabbits.

Abstract：

:Effects of powdered Fagonia cretica plant and its two major triterpenoid saponins (saponin-I and saponin-II), isolated from its ethanolic extract, on red blood cells (RBC) count, haemoglobin concentration (HC), mean corpuscular haemoglobin (MCH) and on total leucocyte (WBC) count of normal male rabbits were investigated. Saponins treated three dose groups of animals indicated significant decrease in RBC count during the experimental period of 16 days. This effect was more pronounced in animals treated with saponin-II than saponin-I. The 0.50 and 1.0g crude drug treated animals and 10 and 20mg of both the saponins treated animals, indicated a decreasing tendency of HC up to the 4th day, which increased afterwards up to the 16th day. The third dose of these materials (1.50g of crude drug and 30mg of both saponins) exhibited a highly significant decreasing pattern, up the 16 days. The decreasing effect of haemoglobin concentration was more distinct in the saponin-II treated animals than saponin-I and the crude drug. The MCH followed a reverse pattern than RBC and HC. A continued decreasing trend was found in total WBC during the 16 days treatment. An amount of 1.50g of the crude drug and 30mg of both the saponins had highly significant decreasing effects on the amount of total leukocyte count of rabbit's blood.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Asif Saeed M,Wahid Sabir A

doi

10.1016/s0378-8741(02)00365-3

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

195-200

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874102003653

journal_volume

85

pub_type

杂志文章

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