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The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens.

Abstract：

:Extracts from Helichrysum aureonitens are used topically by the indigenous people of South Africa against infections. The antimicrobial activity-guided fractionation by bioautography of the acetone extract from the aerial parts of H. aureonitens led to the isolation of 3,5,7-trihydroxyflavone (galangin). Evaluation of the antibacterial activity of the compound against ten randomly selected bacteria indicated significant activity against all the Gram-positive bacteria tested with the minimum inhibitory concentration (MIC) ranging from 0.1 to 0.5 mg/ml. The compound was not active on Gram-negative bacteria except for Enterobacter cloacae which was significantly inhibited at an MIC of 0.1 mg/ml. Galangin indicated considerable activity against the fungi tested with the exception of Cladosporium herbarum. Penicillium digitatum and P. italicum appeared to be particularly susceptible at a concentration of 0.01 mg/ml.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Afolayan AJ,Meyer JJ

doi

10.1016/s0378-8741(97)00065-2

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

177-81

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(97)00065-2

journal_volume

57

pub_type

杂志文章

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