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Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela).

Abstract：

:Achyrocline satureioides (Lam.) DC (Marcela) is known to possess a broad spectrum of pharmacological, medicinal and therapeutic properties. Previous studies have demonstrated various protective abilities of the marcela extracts against various pathological conditions. However, no extensive safety studies have been conducted on these extracts to date. In this paper, we evaluated the acute toxicity (dose levels of 30-300 mg/kg) of an aqueous extract of marcela, administered intraperitoneally and orally in mice and rats. The acute oral maximun tolerable dose in repeated administration during 4 h (1, 3 until 5 g/kg) was also studied in rats. The extract had low acute toxicity when administered intraperitoneally and no toxicity upon oral administration. The LD(50) of aqueous extracts of marcela was found to be greater than 5 g/kg when administered once via gastric intubation to rats. Weight gain, toxicity signs, enzymatic studies (transaminases and phosphatases) and histological evaluation of several organs indicated that the extract was devoid of acute toxicity. These acute studies demonstrated that an aqueous extract of marcela obtained after a 2% infusion is safe and did not cause any detrimental effects in vivo under the conditions investigated in this study.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Rivera F,Gervaz E,Sere C,Dajas F

doi

10.1016/j.jep.2004.08.013

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

359-62

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(04)00384-8

journal_volume

95

pub_type

杂志文章

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